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Common and distinct neural patterns of gray matter alterations in adults with anorexia nervosa and obsessive-compulsive disorder.

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Title: Common and distinct neural patterns of gray matter alterations in adults with anorexia nervosa and obsessive-compulsive disorder.
Authors: Wan, Xinyue (AUTHOR), Zhang, Pengfei (AUTHOR), Jiang, Yanli (AUTHOR), Liu, Guangyao (AUTHOR), Ma, Laiyang (AUTHOR), Zhang, Jing (AUTHOR), Zhang, Jun (AUTHOR)
Source: European Archives of Psychiatry & Clinical Neuroscience. Dec2025, Vol. 275 Issue 8, p2511-2522. 12p.
Subjects: Anorexia nervosa, Obsessive-compulsive disorder, Comorbidity, Brain imaging, Neurological disorders, Gray matter (Nerve tissue), Neuroanatomy, Brain abnormalities
Abstract: Anorexia nervosa (AN) and obsessive-compulsive disorder (OCD) often share multiple similar symptoms and are highly comorbid; however, the common and distinct brain neuroanatomy of these two diseases are unclear. The current study attempted to identify the overlapping and different gray matter volume (GMV) between AN and OCD. We conducted a voxel-wise meta-analysis of GMV using the latest Seed-based d Mapping with Permutation of Subject Images Toolbox (SDM-PSI) software. Compared to healthy controls, patients with AN showed reduced GMV in supplementary motor areas, median cingulate cortices, the left cerebellum, right Rolandic operculum (RO), right insula, right superior temporal gyrus (STG), and right precuneus, while OCD patients were characterized by low GMV in the right insula, STG, RO, and inferior frontal gyrus (IFG). The conjunctional analysis indicated that these two disorders have overlapping structural abnormalities in the right insula, STG, RO and IFG. No distinct GMV alteration was found. These common structural brain abnormalities may underlie the neuropathology of the similar neuropsychological features and highly comorbid manifestations of AN and OCD. [ABSTRACT FROM AUTHOR]
Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Common and distinct neural patterns of gray matter alterations in adults with anorexia nervosa and obsessive-compulsive disorder.
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  Data: <searchLink fieldCode="AR" term="%22Wan%2C+Xinyue%22">Wan, Xinyue</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Pengfei%22">Zhang, Pengfei</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jiang%2C+Yanli%22">Jiang, Yanli</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Guangyao%22">Liu, Guangyao</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ma%2C+Laiyang%22">Ma, Laiyang</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Jing%22">Zhang, Jing</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Jun%22">Zhang, Jun</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Archives+of+Psychiatry+%26+Clinical+Neuroscience%22">European Archives of Psychiatry & Clinical Neuroscience</searchLink>. Dec2025, Vol. 275 Issue 8, p2511-2522. 12p.
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  Data: <searchLink fieldCode="DE" term="%22Anorexia+nervosa%22">Anorexia nervosa</searchLink><br /><searchLink fieldCode="DE" term="%22Obsessive-compulsive+disorder%22">Obsessive-compulsive disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Comorbidity%22">Comorbidity</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+imaging%22">Brain imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Neurological+disorders%22">Neurological disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Gray+matter+%28Nerve+tissue%29%22">Gray matter (Nerve tissue)</searchLink><br /><searchLink fieldCode="DE" term="%22Neuroanatomy%22">Neuroanatomy</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+abnormalities%22">Brain abnormalities</searchLink>
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  Data: Anorexia nervosa (AN) and obsessive-compulsive disorder (OCD) often share multiple similar symptoms and are highly comorbid; however, the common and distinct brain neuroanatomy of these two diseases are unclear. The current study attempted to identify the overlapping and different gray matter volume (GMV) between AN and OCD. We conducted a voxel-wise meta-analysis of GMV using the latest Seed-based d Mapping with Permutation of Subject Images Toolbox (SDM-PSI) software. Compared to healthy controls, patients with AN showed reduced GMV in supplementary motor areas, median cingulate cortices, the left cerebellum, right Rolandic operculum (RO), right insula, right superior temporal gyrus (STG), and right precuneus, while OCD patients were characterized by low GMV in the right insula, STG, RO, and inferior frontal gyrus (IFG). The conjunctional analysis indicated that these two disorders have overlapping structural abnormalities in the right insula, STG, RO and IFG. No distinct GMV alteration was found. These common structural brain abnormalities may underlie the neuropathology of the similar neuropsychological features and highly comorbid manifestations of AN and OCD. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: Dec2025
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