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Prevalence of depression and anxiety in gestational trophoblastic disease: A systematic review and meta-analysis.

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Title: Prevalence of depression and anxiety in gestational trophoblastic disease: A systematic review and meta-analysis.
Authors: Sibarani, Candra Novi Ricardo (AUTHOR), Salima, Siti (AUTHOR), Winarno, Gatot Nyarumenteng Adhipurnawan (AUTHOR), Adrianto, Nicholas (AUTHOR), Mangkuliguna, Ghea (AUTHOR)
Source: Australasian Psychiatry. Dec2025, Vol. 33 Issue 6, p934-940. 7p.
Subjects: Anxiety, Gestational trophoblastic disease, Disease prevalence, Mental depression, Psychological factors, Patient care
Abstract: Objective: The objective of this systematic review and meta-analysis is to determine the prevalence of anxiety and depression among individuals diagnosed with gestational trophoblastic disease (GTD), considering the significant emotional toll associated with miscarriage, surgical procedures, and prolonged β-hCG monitoring. Methods: We systematically searched for studies published up to February 2024 that reported on the prevalence of anxiety and depression in GTD. The databases included PubMed, ScienceDirect, Cochrane Library, EBSCOHost, ProQuest, and Google Scholar. Data from the included studies were independently extracted by four researchers and analyzed using MedCalc v19.5.1. This study was registered with PROSPERO (registration number CRD42024525746). Results: Our analysis included seven studies involving a total of 462 participants. The findings revealed an overall prevalence of anxiety at 34.9% and depression at 22.2%, indicating a significant psychological impact on patients with GTD. Conclusion: The high prevalence of anxiety and depression underscores the necessity for physicians to provide comprehensive psychological support to patients with GTD. Educating patients about their disorder, treatment options, and potential consequences is crucial for managing the psychological aspects of GTD. [ABSTRACT FROM AUTHOR]
Copyright of Australasian Psychiatry is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Prevalence of depression and anxiety in gestational trophoblastic disease: A systematic review and meta-analysis.
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  Data: <searchLink fieldCode="AR" term="%22Sibarani%2C+Candra+Novi+Ricardo%22">Sibarani, Candra Novi Ricardo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Salima%2C+Siti%22">Salima, Siti</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Winarno%2C+Gatot+Nyarumenteng+Adhipurnawan%22">Winarno, Gatot Nyarumenteng Adhipurnawan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Adrianto%2C+Nicholas%22">Adrianto, Nicholas</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mangkuliguna%2C+Ghea%22">Mangkuliguna, Ghea</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Australasian+Psychiatry%22">Australasian Psychiatry</searchLink>. Dec2025, Vol. 33 Issue 6, p934-940. 7p.
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  Data: <searchLink fieldCode="DE" term="%22Anxiety%22">Anxiety</searchLink><br /><searchLink fieldCode="DE" term="%22Gestational+trophoblastic+disease%22">Gestational trophoblastic disease</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+prevalence%22">Disease prevalence</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Psychological+factors%22">Psychological factors</searchLink><br /><searchLink fieldCode="DE" term="%22Patient+care%22">Patient care</searchLink>
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  Data: Objective: The objective of this systematic review and meta-analysis is to determine the prevalence of anxiety and depression among individuals diagnosed with gestational trophoblastic disease (GTD), considering the significant emotional toll associated with miscarriage, surgical procedures, and prolonged β-hCG monitoring. Methods: We systematically searched for studies published up to February 2024 that reported on the prevalence of anxiety and depression in GTD. The databases included PubMed, ScienceDirect, Cochrane Library, EBSCOHost, ProQuest, and Google Scholar. Data from the included studies were independently extracted by four researchers and analyzed using MedCalc v19.5.1. This study was registered with PROSPERO (registration number CRD42024525746). Results: Our analysis included seven studies involving a total of 462 participants. The findings revealed an overall prevalence of anxiety at 34.9% and depression at 22.2%, indicating a significant psychological impact on patients with GTD. Conclusion: The high prevalence of anxiety and depression underscores the necessity for physicians to provide comprehensive psychological support to patients with GTD. Educating patients about their disorder, treatment options, and potential consequences is crucial for managing the psychological aspects of GTD. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Australasian Psychiatry is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=189650226
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              Text: Dec2025
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