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High‐Density Lipoprotein Cholesterol Links Peripheral Lipid Metabolism to Brain Structure and Cognition.

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Title: High‐Density Lipoprotein Cholesterol Links Peripheral Lipid Metabolism to Brain Structure and Cognition.
Authors: Li, Jiatong (AUTHOR), Guan, Tianshu (AUTHOR), Zhu, Dongqing (AUTHOR), Yang, Wenbo (AUTHOR), Yang, Liu (AUTHOR), Gong, Weikang (AUTHOR), Liu, Xiaoni (AUTHOR), You, Jia (AUTHOR), Feng, Jianfeng (AUTHOR), Chen, Xiangjun (AUTHOR), Cumming, Paul (AUTHOR)
Source: Acta Neurologica Scandinavica. 11/27/2025, Vol. 2025, p1-11. 11p.
Subjects: High density lipoproteins, Cholesterol, Disease risk factors, Cognitive ability, Brain anatomy, Lipid metabolism, Neurobiology, Dietary patterns
Abstract: Objective: The objective of this study is to assess dementia risk and cognitive function in relation to serum lipid levels and to elucidate the potential neurobiological mechanisms underlying these associations, which may be mediated by alterations in brain structures. Methods: This study utilized UK Biobank data, incorporating dementia diagnoses, biochemistry tests, and brain structural imaging. The associations between baseline serum lipid levels and dementia diagnosis during follow‐up were analyzed using generalized additive models with shrinkage smoothers. The associations between serum lipid levels and brain structure measures were also explored. Structural equation modeling was employed to elucidate the potential links between serum lipids, brain structures, and cognitive impairment. Results: In 283,234 participants, combining dementia diagnoses with blood biochemistry data, HDL‐C levels showed a nearly significant negative linear correlation with dementia diagnosis (edf ≈ 1, p = 0.057) after appropriate adjustments. HDL‐C also exhibited linear associations with several brain structure indicators, including the volume of the right accumbens area and the central corpus callosum, the area of the superior parietal region, and the mean cortical thickness of the right lateral occipital, right superior frontal, and left transverse temporal regions. Structural equation modeling in 19,707 participants revealed that HDL‐C was a significant negative predictor of cognitive impairment, with this association potentially mediated by the positive effect of HDL‐C on brain volume. Conclusion: These findings suggest a potential protective role of HDL‐C against dementia and highlight dietary interventions as a feasible and accessible strategy for dementia prevention. [ABSTRACT FROM AUTHOR]
Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: High‐Density Lipoprotein Cholesterol Links Peripheral Lipid Metabolism to Brain Structure and Cognition.
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  Data: <searchLink fieldCode="AR" term="%22Li%2C+Jiatong%22">Li, Jiatong</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Guan%2C+Tianshu%22">Guan, Tianshu</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhu%2C+Dongqing%22">Zhu, Dongqing</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yang%2C+Wenbo%22">Yang, Wenbo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yang%2C+Liu%22">Yang, Liu</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gong%2C+Weikang%22">Gong, Weikang</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Xiaoni%22">Liu, Xiaoni</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22You%2C+Jia%22">You, Jia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Feng%2C+Jianfeng%22">Feng, Jianfeng</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Xiangjun%22">Chen, Xiangjun</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cumming%2C+Paul%22">Cumming, Paul</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Acta+Neurologica+Scandinavica%22">Acta Neurologica Scandinavica</searchLink>. 11/27/2025, Vol. 2025, p1-11. 11p.
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  Data: <searchLink fieldCode="DE" term="%22High+density+lipoproteins%22">High density lipoproteins</searchLink><br /><searchLink fieldCode="DE" term="%22Cholesterol%22">Cholesterol</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+risk+factors%22">Disease risk factors</searchLink><br /><searchLink fieldCode="DE" term="%22Cognitive+ability%22">Cognitive ability</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+anatomy%22">Brain anatomy</searchLink><br /><searchLink fieldCode="DE" term="%22Lipid+metabolism%22">Lipid metabolism</searchLink><br /><searchLink fieldCode="DE" term="%22Neurobiology%22">Neurobiology</searchLink><br /><searchLink fieldCode="DE" term="%22Dietary+patterns%22">Dietary patterns</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective: The objective of this study is to assess dementia risk and cognitive function in relation to serum lipid levels and to elucidate the potential neurobiological mechanisms underlying these associations, which may be mediated by alterations in brain structures. Methods: This study utilized UK Biobank data, incorporating dementia diagnoses, biochemistry tests, and brain structural imaging. The associations between baseline serum lipid levels and dementia diagnosis during follow‐up were analyzed using generalized additive models with shrinkage smoothers. The associations between serum lipid levels and brain structure measures were also explored. Structural equation modeling was employed to elucidate the potential links between serum lipids, brain structures, and cognitive impairment. Results: In 283,234 participants, combining dementia diagnoses with blood biochemistry data, HDL‐C levels showed a nearly significant negative linear correlation with dementia diagnosis (edf ≈ 1, p = 0.057) after appropriate adjustments. HDL‐C also exhibited linear associations with several brain structure indicators, including the volume of the right accumbens area and the central corpus callosum, the area of the superior parietal region, and the mean cortical thickness of the right lateral occipital, right superior frontal, and left transverse temporal regions. Structural equation modeling in 19,707 participants revealed that HDL‐C was a significant negative predictor of cognitive impairment, with this association potentially mediated by the positive effect of HDL‐C on brain volume. Conclusion: These findings suggest a potential protective role of HDL‐C against dementia and highlight dietary interventions as a feasible and accessible strategy for dementia prevention. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1155/ane/8831825
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        Text: English
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      – SubjectFull: High density lipoproteins
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      – SubjectFull: Disease risk factors
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      – SubjectFull: Cognitive ability
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      – SubjectFull: Brain anatomy
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      – SubjectFull: Lipid metabolism
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      – SubjectFull: Dietary patterns
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              Text: 11/27/2025
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