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Glycosylation at the Crossroads of Cancer and Neurodevelopmental Disorders: A Shared Molecular Landscape.

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Title: Glycosylation at the Crossroads of Cancer and Neurodevelopmental Disorders: A Shared Molecular Landscape.
Authors: Sarantis, Panagiotis (AUTHOR), Papavassiliou, Kostas A. (AUTHOR), Papavassiliou, Athanasios G. (AUTHOR)
Source: European Journal of Neuroscience. Nov2025, Vol. 62 Issue 10, p1-5. 5p.
Subjects: Glycosylation, Autism spectrum disorders, Tumors, Attention-deficit hyperactivity disorder, Neural development, Drug target, Cell communication
Abstract: The article focuses on the role of glycosylation as a significant molecular mechanism linking cancer progression to neurodevelopmental disorders (NDDs) such as autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). It discusses how glycosylation, an enzymatic process that modifies proteins and lipids, influences cellular communication, immune responses, and signaling pathways critical to both cancer and NDDs. The authors highlight shared molecular pathways, such as the phosphoinositide 3-kinase (PI3K)/protein kinase B (PKB, Akt)/mechanistic target of rapamycin (mTOR) pathway, and suggest that insights from cancer research could lead to innovative therapeutic targets and biomarkers for NDDs. The commentary emphasizes the potential for glycosylation to serve as a therapeutic target, bridging the fields of oncology and neurology in the pursuit of precision medicine. [Extracted from the article]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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DbLabel: Psychology and Behavioral Sciences Collection
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PubType: Academic Journal
PubTypeId: academicJournal
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IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Glycosylation at the Crossroads of Cancer and Neurodevelopmental Disorders: A Shared Molecular Landscape.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Sarantis%2C+Panagiotis%22">Sarantis, Panagiotis</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Papavassiliou%2C+Kostas A%2E%22">Papavassiliou, Kostas A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Papavassiliou%2C+Athanasios G%2E%22">Papavassiliou, Athanasios G.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Nov2025, Vol. 62 Issue 10, p1-5. 5p.
– Name: Subject
  Label: Subjects
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  Data: <searchLink fieldCode="DE" term="%22Glycosylation%22">Glycosylation</searchLink><br /><searchLink fieldCode="DE" term="%22Autism+spectrum+disorders%22">Autism spectrum disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Tumors%22">Tumors</searchLink><br /><searchLink fieldCode="DE" term="%22Attention-deficit+hyperactivity+disorder%22">Attention-deficit hyperactivity disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Neural+development%22">Neural development</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+target%22">Drug target</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+communication%22">Cell communication</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The article focuses on the role of glycosylation as a significant molecular mechanism linking cancer progression to neurodevelopmental disorders (NDDs) such as autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). It discusses how glycosylation, an enzymatic process that modifies proteins and lipids, influences cellular communication, immune responses, and signaling pathways critical to both cancer and NDDs. The authors highlight shared molecular pathways, such as the phosphoinositide 3-kinase (PI3K)/protein kinase B (PKB, Akt)/mechanistic target of rapamycin (mTOR) pathway, and suggest that insights from cancer research could lead to innovative therapeutic targets and biomarkers for NDDs. The commentary emphasizes the potential for glycosylation to serve as a therapeutic target, bridging the fields of oncology and neurology in the pursuit of precision medicine. [Extracted from the article]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=189709223
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      – Type: doi
        Value: 10.1111/ejn.70341
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      – Code: eng
        Text: English
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      – SubjectFull: Glycosylation
        Type: general
      – SubjectFull: Autism spectrum disorders
        Type: general
      – SubjectFull: Tumors
        Type: general
      – SubjectFull: Attention-deficit hyperactivity disorder
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      – SubjectFull: Neural development
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      – SubjectFull: Drug target
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      – SubjectFull: Cell communication
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      – TitleFull: Glycosylation at the Crossroads of Cancer and Neurodevelopmental Disorders: A Shared Molecular Landscape.
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              Text: Nov2025
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              Y: 2025
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