Glycosylation at the Crossroads of Cancer and Neurodevelopmental Disorders: A Shared Molecular Landscape.
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| Title: | Glycosylation at the Crossroads of Cancer and Neurodevelopmental Disorders: A Shared Molecular Landscape. |
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| Authors: | Sarantis, Panagiotis (AUTHOR), Papavassiliou, Kostas A. (AUTHOR), Papavassiliou, Athanasios G. (AUTHOR) |
| Source: | European Journal of Neuroscience. Nov2025, Vol. 62 Issue 10, p1-5. 5p. |
| Subjects: | Glycosylation, Autism spectrum disorders, Tumors, Attention-deficit hyperactivity disorder, Neural development, Drug target, Cell communication |
| Abstract: | The article focuses on the role of glycosylation as a significant molecular mechanism linking cancer progression to neurodevelopmental disorders (NDDs) such as autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). It discusses how glycosylation, an enzymatic process that modifies proteins and lipids, influences cellular communication, immune responses, and signaling pathways critical to both cancer and NDDs. The authors highlight shared molecular pathways, such as the phosphoinositide 3-kinase (PI3K)/protein kinase B (PKB, Akt)/mechanistic target of rapamycin (mTOR) pathway, and suggest that insights from cancer research could lead to innovative therapeutic targets and biomarkers for NDDs. The commentary emphasizes the potential for glycosylation to serve as a therapeutic target, bridging the fields of oncology and neurology in the pursuit of precision medicine. [Extracted from the article] |
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| Database: | Psychology and Behavioral Sciences Collection |
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