"The Idea of Being Without It is Frightening". Uncertainty and Psychological Dependency for Patients Using Immuno‐, Biological, or Precision Therapies: A Qualitative Study.
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| Title: | "The Idea of Being Without It is Frightening". Uncertainty and Psychological Dependency for Patients Using Immuno‐, Biological, or Precision Therapies: A Qualitative Study. |
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| Authors: | Lecouturier, J. (AUTHOR), Crowe, L. (AUTHOR), Brown, M. C. (AUTHOR), Greystoke, A. (AUTHOR), Bojke, A. (AUTHOR), Bojke, R. (AUTHOR), Richardson, J. (AUTHOR), Wells, M. (AUTHOR), Ezeala, E. (AUTHOR), Carter, L. (AUTHOR), Sharp, L. (AUTHOR), Todd, A. (AUTHOR) |
| Source: | Psycho-Oncology. Nov2025, Vol. 34 Issue 11, p1-10. 10p. |
| Subjects: | Uncertainty (Information theory), Cancer patients, Addictions, Biologicals, Qualitative research, Cancer treatment, Psychological factors, Patients' attitudes |
| Abstract: | Background: IBP therapies (immunotherapies, biologics and precision therapies) have had a significant impact on cancer survival. They differ from conventional cancer treatments in that they may be used long term and have less predictable adverse effects. We aimed to explore the psychological impact of IBP therapies from the perspectives of those living with advanced cancer. Methods: Semi‐structured interviews with 20 women and 11 men with advanced cancer ‐ (lung, colorectal, ovary, (female) breast, renal and malignant melanoma) ‐ about their experiences of IBP therapies. Data were analysed thematically. Results: We elicited two overarching themes from the data: (1) the psychological impact of a stage IV diagnosis and living with advanced cancer, and (2) uncertainty and dependency associated with IBP therapies. Although some were relieved to have a diagnosis, others responded with shock and disbelief. Day to day, cancer was foremost in the minds of many, and the remainder chose to push these thoughts aside and focus on making the most of life. Living with cancer led to a shift in their sense of self. Uncertainty and dependency throughout the care pathway were centred around treatment effectiveness, heightened by the belief that the therapy was keeping them alive. Participants were uncertain and anxious about any interruption of, or changes to, their current treatment regimen, stopping their current treatment and next steps. Conclusion: Interventions are needed to support the psychological needs of people using IBP therapies. These should go beyond monitoring and managing IBP treatment‐related adverse effects and address uncertainty and psychological dependency. [ABSTRACT FROM AUTHOR] |
| Copyright of Psycho-Oncology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 189713209 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: "The Idea of Being Without It is Frightening". Uncertainty and Psychological Dependency for Patients Using Immuno‐, Biological, or Precision Therapies: A Qualitative Study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Lecouturier%2C+J%2E%22">Lecouturier, J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Crowe%2C+L%2E%22">Crowe, L.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Brown%2C+M%2E+C%2E%22">Brown, M. C.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Greystoke%2C+A%2E%22">Greystoke, A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bojke%2C+A%2E%22">Bojke, A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bojke%2C+R%2E%22">Bojke, R.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Richardson%2C+J%2E%22">Richardson, J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wells%2C+M%2E%22">Wells, M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ezeala%2C+E%2E%22">Ezeala, E.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Carter%2C+L%2E%22">Carter, L.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sharp%2C+L%2E%22">Sharp, L.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Todd%2C+A%2E%22">Todd, A.</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Psycho-Oncology%22">Psycho-Oncology</searchLink>. Nov2025, Vol. 34 Issue 11, p1-10. 10p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Uncertainty+%28Information+theory%29%22">Uncertainty (Information theory)</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+patients%22">Cancer patients</searchLink><br /><searchLink fieldCode="DE" term="%22Addictions%22">Addictions</searchLink><br /><searchLink fieldCode="DE" term="%22Biologicals%22">Biologicals</searchLink><br /><searchLink fieldCode="DE" term="%22Qualitative+research%22">Qualitative research</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+treatment%22">Cancer treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Psychological+factors%22">Psychological factors</searchLink><br /><searchLink fieldCode="DE" term="%22Patients'+attitudes%22">Patients' attitudes</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background: IBP therapies (immunotherapies, biologics and precision therapies) have had a significant impact on cancer survival. They differ from conventional cancer treatments in that they may be used long term and have less predictable adverse effects. We aimed to explore the psychological impact of IBP therapies from the perspectives of those living with advanced cancer. Methods: Semi‐structured interviews with 20 women and 11 men with advanced cancer ‐ (lung, colorectal, ovary, (female) breast, renal and malignant melanoma) ‐ about their experiences of IBP therapies. Data were analysed thematically. Results: We elicited two overarching themes from the data: (1) the psychological impact of a stage IV diagnosis and living with advanced cancer, and (2) uncertainty and dependency associated with IBP therapies. Although some were relieved to have a diagnosis, others responded with shock and disbelief. Day to day, cancer was foremost in the minds of many, and the remainder chose to push these thoughts aside and focus on making the most of life. Living with cancer led to a shift in their sense of self. Uncertainty and dependency throughout the care pathway were centred around treatment effectiveness, heightened by the belief that the therapy was keeping them alive. Participants were uncertain and anxious about any interruption of, or changes to, their current treatment regimen, stopping their current treatment and next steps. Conclusion: Interventions are needed to support the psychological needs of people using IBP therapies. These should go beyond monitoring and managing IBP treatment‐related adverse effects and address uncertainty and psychological dependency. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Psycho-Oncology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/pon.70318 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 1 Subjects: – SubjectFull: Uncertainty (Information theory) Type: general – SubjectFull: Cancer patients Type: general – SubjectFull: Addictions Type: general – SubjectFull: Biologicals Type: general – SubjectFull: Qualitative research Type: general – SubjectFull: Cancer treatment Type: general – SubjectFull: Psychological factors Type: general – SubjectFull: Patients' attitudes Type: general Titles: – TitleFull: "The Idea of Being Without It is Frightening". Uncertainty and Psychological Dependency for Patients Using Immuno‐, Biological, or Precision Therapies: A Qualitative Study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Lecouturier, J. – PersonEntity: Name: NameFull: Crowe, L. – PersonEntity: Name: NameFull: Brown, M. C. – PersonEntity: Name: NameFull: Greystoke, A. – PersonEntity: Name: NameFull: Bojke, A. – PersonEntity: Name: NameFull: Bojke, R. – PersonEntity: Name: NameFull: Richardson, J. – PersonEntity: Name: NameFull: Wells, M. – PersonEntity: Name: NameFull: Ezeala, E. – PersonEntity: Name: NameFull: Carter, L. – PersonEntity: Name: NameFull: Sharp, L. – PersonEntity: Name: NameFull: Todd, A. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 11 Text: Nov2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 10579249 Numbering: – Type: volume Value: 34 – Type: issue Value: 11 Titles: – TitleFull: Psycho-Oncology Type: main |
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