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Optical coherence tomography findings in primary headache disorders: is pain duration a clinical correlate?

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Title: Optical coherence tomography findings in primary headache disorders: is pain duration a clinical correlate?
Authors: Taskiran-Sag, Aslihan (AUTHOR), Yazgi, Hare (AUTHOR), Ozulken, Kemal (AUTHOR), Eroglu, Erdal (AUTHOR)
Source: International Journal of Neuroscience. Dec2025, Vol. 135 Issue 12, p1321-1327. 7p.
Subjects: Primary headache disorders, Migraine, Symptoms, Chronic pain, Nerve tissue, Optical coherence tomography, Tension headache
Abstract: Objective: Ganglion cell layer thickness (GCLT) may be used as a potential marker for central neural changes. We compared GCLT by using spectral domain optical coherence tomography (SD-OCT) in patients with primary headache disorders and healthy controls. We seek whether there was any difference between the headache groups and whether any clinical parameters correlated to GCLT. Methods: Fifty-three primary headache patients, 11 age and sex-matched healthy subjects were included in this cross-sectional study after power analysis. All subjects underwent SD-OCT. The duration of disorder, headache frequency, severity, duration of pain, presence of ocular pain, and accompanying symptoms have been collected. Results: Mean GCLT of the headache group was 15.7 ± 3.8 µm (mean ± standard deviation), and the control group was 17.5 ± 2.4. The difference was not statistically significant. When we compared the controls, migraine and tension-type headache patients' GCLT values, we found a significant difference (ANOVA, p = 0.001). Migraine patients had thinner GCLT compared to all non-migraine headache patients (p = 0.01). Intraocular pressure values of migraine patients and non-migraine patients were not statistically significantly different (p = 0.13). The only clinical parameter that correlated with GCLT was pain duration (r = −0.43 and p = 0.01). The patients with white matter lesions had thinner GCLT (p = 0.046). Conclusion: Our results suggest that not long-term suffering from pain but migraine pathophysiology itself seems to affect neuroretinal tissue. Pain duration was moderately and inversely correlated to GCLT, meaning that the longer the headache, the thinner the ganglion cell layer is. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
  Group: Ti
  Data: Optical coherence tomography findings in primary headache disorders: is pain duration a clinical correlate?
– Name: Author
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  Data: <searchLink fieldCode="AR" term="%22Taskiran-Sag%2C+Aslihan%22">Taskiran-Sag, Aslihan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yazgi%2C+Hare%22">Yazgi, Hare</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ozulken%2C+Kemal%22">Ozulken, Kemal</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Eroglu%2C+Erdal%22">Eroglu, Erdal</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Neuroscience%22">International Journal of Neuroscience</searchLink>. Dec2025, Vol. 135 Issue 12, p1321-1327. 7p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Primary+headache+disorders%22">Primary headache disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Migraine%22">Migraine</searchLink><br /><searchLink fieldCode="DE" term="%22Symptoms%22">Symptoms</searchLink><br /><searchLink fieldCode="DE" term="%22Chronic+pain%22">Chronic pain</searchLink><br /><searchLink fieldCode="DE" term="%22Nerve+tissue%22">Nerve tissue</searchLink><br /><searchLink fieldCode="DE" term="%22Optical+coherence+tomography%22">Optical coherence tomography</searchLink><br /><searchLink fieldCode="DE" term="%22Tension+headache%22">Tension headache</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective: Ganglion cell layer thickness (GCLT) may be used as a potential marker for central neural changes. We compared GCLT by using spectral domain optical coherence tomography (SD-OCT) in patients with primary headache disorders and healthy controls. We seek whether there was any difference between the headache groups and whether any clinical parameters correlated to GCLT. Methods: Fifty-three primary headache patients, 11 age and sex-matched healthy subjects were included in this cross-sectional study after power analysis. All subjects underwent SD-OCT. The duration of disorder, headache frequency, severity, duration of pain, presence of ocular pain, and accompanying symptoms have been collected. Results: Mean GCLT of the headache group was 15.7 ± 3.8 µm (mean ± standard deviation), and the control group was 17.5 ± 2.4. The difference was not statistically significant. When we compared the controls, migraine and tension-type headache patients' GCLT values, we found a significant difference (ANOVA, p = 0.001). Migraine patients had thinner GCLT compared to all non-migraine headache patients (p = 0.01). Intraocular pressure values of migraine patients and non-migraine patients were not statistically significantly different (p = 0.13). The only clinical parameter that correlated with GCLT was pain duration (r = −0.43 and p = 0.01). The patients with white matter lesions had thinner GCLT (p = 0.046). Conclusion: Our results suggest that not long-term suffering from pain but migraine pathophysiology itself seems to affect neuroretinal tissue. Pain duration was moderately and inversely correlated to GCLT, meaning that the longer the headache, the thinner the ganglion cell layer is. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/00207454.2024.2358367
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      – Code: eng
        Text: English
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        PageCount: 7
        StartPage: 1321
    Subjects:
      – SubjectFull: Primary headache disorders
        Type: general
      – SubjectFull: Migraine
        Type: general
      – SubjectFull: Symptoms
        Type: general
      – SubjectFull: Chronic pain
        Type: general
      – SubjectFull: Nerve tissue
        Type: general
      – SubjectFull: Optical coherence tomography
        Type: general
      – SubjectFull: Tension headache
        Type: general
    Titles:
      – TitleFull: Optical coherence tomography findings in primary headache disorders: is pain duration a clinical correlate?
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            NameFull: Taskiran-Sag, Aslihan
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            NameFull: Yazgi, Hare
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            NameFull: Ozulken, Kemal
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            – D: 01
              M: 12
              Text: Dec2025
              Type: published
              Y: 2025
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