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Moderators of treatment effect in a randomised controlled trial of single‐ and multi‐family therapy for anorexia nervosa in adolescents and emerging adults.

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Title: Moderators of treatment effect in a randomised controlled trial of single‐ and multi‐family therapy for anorexia nervosa in adolescents and emerging adults.
Authors: Baudinet, Julian (AUTHOR), Hodsoll, John (AUTHOR), Schmidt, Ulrike (AUTHOR), Simic, Mima (AUTHOR), Landau, Sabine (AUTHOR), Eisler, Ivan (AUTHOR)
Source: European Eating Disorders Review. Jan2026, Vol. 34 Issue 1, p17-28. 12p.
Subjects: Anorexia nervosa treatment, Family psychotherapy, Research funding, Secondary analysis, Body mass index, Body weight, Questionnaires, Treatment effectiveness, Descriptive statistics, Parent attitudes, Research, Data analysis software, Confidence intervals, Psychology of caregivers, Psychology of parents, Comparative studies, Regression analysis, Adolescence, Adults
Abstract: Introduction: Multi‐family therapy for anorexia nervosa (MFT‐AN) is a novel, group‐based intervention that intensifies single‐family therapy for anorexia nervosa (FT‐AN), with the aim of improving outcomes. The current study explored treatment moderators in a randomised controlled trial (N = 167) of FT‐AN and MFT‐AN for young people (adolescents/emerging adults aged 13–20 years) with anorexia nervosa. Methods: Data were analysed using multiple linear regression. Six hypothesised baseline participant and parent factors were tested as possible moderators of treatment effect on end‐of‐treatment and follow‐up percentage of median Body Mass Index (%mBMI); age, eating disorder symptom severity, perceived family conflict (young person and parent ratings) and parent‐rated experiences of caregiving (positive and negative). Results: Greater parent‐rated positive caregiving experiences moderated treatment outcomes at follow‐up (β = −0.47, 95%CI: −0.91, −0.03, p = 0.04), but not end‐of‐treatment. Participants who had fewer parent‐rated positive caregiving experiences at baseline had higher weight at follow‐up if they had MFT‐AN compared to FT‐AN. No other hypothesised baseline factors moderated treatment outcome (p's > 0.05). Discussion: The current study suggests MFT‐AN may be indicated for families who present with fewer positive caregiving experiences to treatment. The MFT‐AN group context may help to promote mentalisation and hope for these families, which may be harder to achieve in single‐family treatment. Future research is needed to empirically evaluate how and why MFT‐AN supports this group more. Trial Registration: ISRCTN registry: ISRCTN11275465, registered 29 January 2007. Highlights: The current study suggests multi‐family therapy for anorexia nervosa (MFT‐AN) may be indicated for families who present to treatment with fewer positive caregiving experiences.The MFT‐AN group context may help to promote mentalisation and hope for these families, which may be harder to achieve in single‐family treatment.This study did not find evidence that age, eating disorder symptom severity, perceived family conflict or level of negative caregiving experiences moderated treatment effect. [ABSTRACT FROM AUTHOR]
Copyright of European Eating Disorders Review is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Moderators of treatment effect in a randomised controlled trial of single‐ and multi‐family therapy for anorexia nervosa in adolescents and emerging adults.
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  Data: <searchLink fieldCode="AR" term="%22Baudinet%2C+Julian%22">Baudinet, Julian</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hodsoll%2C+John%22">Hodsoll, John</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schmidt%2C+Ulrike%22">Schmidt, Ulrike</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Simic%2C+Mima%22">Simic, Mima</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Landau%2C+Sabine%22">Landau, Sabine</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Eisler%2C+Ivan%22">Eisler, Ivan</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Eating+Disorders+Review%22">European Eating Disorders Review</searchLink>. Jan2026, Vol. 34 Issue 1, p17-28. 12p.
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  Data: <searchLink fieldCode="DE" term="%22Anorexia+nervosa+treatment%22">Anorexia nervosa treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Family+psychotherapy%22">Family psychotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Secondary+analysis%22">Secondary analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Body+mass+index%22">Body mass index</searchLink><br /><searchLink fieldCode="DE" term="%22Body+weight%22">Body weight</searchLink><br /><searchLink fieldCode="DE" term="%22Questionnaires%22">Questionnaires</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Parent+attitudes%22">Parent attitudes</searchLink><br /><searchLink fieldCode="DE" term="%22Research%22">Research</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis+software%22">Data analysis software</searchLink><br /><searchLink fieldCode="DE" term="%22Confidence+intervals%22">Confidence intervals</searchLink><br /><searchLink fieldCode="DE" term="%22Psychology+of+caregivers%22">Psychology of caregivers</searchLink><br /><searchLink fieldCode="DE" term="%22Psychology+of+parents%22">Psychology of parents</searchLink><br /><searchLink fieldCode="DE" term="%22Comparative+studies%22">Comparative studies</searchLink><br /><searchLink fieldCode="DE" term="%22Regression+analysis%22">Regression analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Adolescence%22">Adolescence</searchLink><br /><searchLink fieldCode="DE" term="%22Adults%22">Adults</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Introduction: Multi‐family therapy for anorexia nervosa (MFT‐AN) is a novel, group‐based intervention that intensifies single‐family therapy for anorexia nervosa (FT‐AN), with the aim of improving outcomes. The current study explored treatment moderators in a randomised controlled trial (N = 167) of FT‐AN and MFT‐AN for young people (adolescents/emerging adults aged 13–20 years) with anorexia nervosa. Methods: Data were analysed using multiple linear regression. Six hypothesised baseline participant and parent factors were tested as possible moderators of treatment effect on end‐of‐treatment and follow‐up percentage of median Body Mass Index (%mBMI); age, eating disorder symptom severity, perceived family conflict (young person and parent ratings) and parent‐rated experiences of caregiving (positive and negative). Results: Greater parent‐rated positive caregiving experiences moderated treatment outcomes at follow‐up (β = −0.47, 95%CI: −0.91, −0.03, p = 0.04), but not end‐of‐treatment. Participants who had fewer parent‐rated positive caregiving experiences at baseline had higher weight at follow‐up if they had MFT‐AN compared to FT‐AN. No other hypothesised baseline factors moderated treatment outcome (p's > 0.05). Discussion: The current study suggests MFT‐AN may be indicated for families who present with fewer positive caregiving experiences to treatment. The MFT‐AN group context may help to promote mentalisation and hope for these families, which may be harder to achieve in single‐family treatment. Future research is needed to empirically evaluate how and why MFT‐AN supports this group more. Trial Registration: ISRCTN registry: ISRCTN11275465, registered 29 January 2007. Highlights: The current study suggests multi‐family therapy for anorexia nervosa (MFT‐AN) may be indicated for families who present to treatment with fewer positive caregiving experiences.The MFT‐AN group context may help to promote mentalisation and hope for these families, which may be harder to achieve in single‐family treatment.This study did not find evidence that age, eating disorder symptom severity, perceived family conflict or level of negative caregiving experiences moderated treatment effect. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Eating Disorders Review is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1002/erv.3050
    Languages:
      – Code: eng
        Text: English
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        PageCount: 12
        StartPage: 17
    Subjects:
      – SubjectFull: Anorexia nervosa treatment
        Type: general
      – SubjectFull: Family psychotherapy
        Type: general
      – SubjectFull: Research funding
        Type: general
      – SubjectFull: Secondary analysis
        Type: general
      – SubjectFull: Body mass index
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      – SubjectFull: Body weight
        Type: general
      – SubjectFull: Questionnaires
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      – SubjectFull: Treatment effectiveness
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      – SubjectFull: Descriptive statistics
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      – SubjectFull: Parent attitudes
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      – SubjectFull: Research
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      – SubjectFull: Data analysis software
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      – SubjectFull: Confidence intervals
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      – SubjectFull: Psychology of caregivers
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      – SubjectFull: Psychology of parents
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      – SubjectFull: Comparative studies
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      – SubjectFull: Regression analysis
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      – SubjectFull: Adolescence
        Type: general
      – SubjectFull: Adults
        Type: general
    Titles:
      – TitleFull: Moderators of treatment effect in a randomised controlled trial of single‐ and multi‐family therapy for anorexia nervosa in adolescents and emerging adults.
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              Text: Jan2026
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              Y: 2026
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