View in EDS HTML Full Text PDF Full Text

MR MORPHOMETRY ANALYSIS OF GREY MATTER VOLUME REDUCTION IN SCHIZOPHRENIA: ASSOCIATION WITH HALLUCINATIONS.

Saved in:
Bibliographic Details
Title: MR MORPHOMETRY ANALYSIS OF GREY MATTER VOLUME REDUCTION IN SCHIZOPHRENIA: ASSOCIATION WITH HALLUCINATIONS.
Authors: NECKELMANN, GESCHE (AUTHOR), SPECHT, KARSTEN (AUTHOR), LUND, ANDERS (AUTHOR), ERSLAND, LARS (AUTHOR), SMIEVOLL, ALF INGE (AUTHOR), NECKELMANN, DAG (AUTHOR), HUGDAHL, KENNETH (AUTHOR)
Source: International Journal of Neuroscience. Jan2006, Vol. 116 Issue 1, p9-23. 15p. 2 Diagrams.
Subjects: Hallucinations, People with schizophrenia, Auditory perception, Speech perception, Psychoses, Pathological psychology
Abstract: The authors used voxel-based morphometry (VBM) to study GM volume differences in the whole brain volume between a group of patients with schizophrenia and a healthy control group. There were 12 patients and 12 control subjects. The subjects were scanned in a 1.5 T MR scanner. The patients had all been evaluated by a senior psychiatrist on the brief psychiatric rating scale (BPRS). The VBM data was correlated with reports of rate and frequency of hallucinations based on their scores on the BPRS hallucination item. There were significant grey matter volume reductions in the schizophrenia patient group in the left superior (transverse) temporal gyrus, the left middle frontal gyrus, and in the right cuneus. Areas of grey matter volume reduction that correlated negatively with hallucinations were found in the left superior (transverse) temporal gyrus, left thalamus, and left and right cerebellum. This article proposes that significant reductions in grey matter volume may be instrumental in generating spontaneous neuronal activity that is associated with speech perception experiences in the absence of an external acoustic stimulus that may cause hallucinations. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 19020022
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: MR MORPHOMETRY ANALYSIS OF GREY MATTER VOLUME REDUCTION IN SCHIZOPHRENIA: ASSOCIATION WITH HALLUCINATIONS.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22NECKELMANN%2C+GESCHE%22">NECKELMANN, GESCHE</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22SPECHT%2C+KARSTEN%22">SPECHT, KARSTEN</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22LUND%2C+ANDERS%22">LUND, ANDERS</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22ERSLAND%2C+LARS%22">ERSLAND, LARS</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22SMIEVOLL%2C+ALF+INGE%22">SMIEVOLL, ALF INGE</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22NECKELMANN%2C+DAG%22">NECKELMANN, DAG</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22HUGDAHL%2C+KENNETH%22">HUGDAHL, KENNETH</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Neuroscience%22">International Journal of Neuroscience</searchLink>. Jan2006, Vol. 116 Issue 1, p9-23. 15p. 2 Diagrams.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Hallucinations%22">Hallucinations</searchLink><br /><searchLink fieldCode="DE" term="%22People+with+schizophrenia%22">People with schizophrenia</searchLink><br /><searchLink fieldCode="DE" term="%22Auditory+perception%22">Auditory perception</searchLink><br /><searchLink fieldCode="DE" term="%22Speech+perception%22">Speech perception</searchLink><br /><searchLink fieldCode="DE" term="%22Psychoses%22">Psychoses</searchLink><br /><searchLink fieldCode="DE" term="%22Pathological+psychology%22">Pathological psychology</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The authors used voxel-based morphometry (VBM) to study GM volume differences in the whole brain volume between a group of patients with schizophrenia and a healthy control group. There were 12 patients and 12 control subjects. The subjects were scanned in a 1.5 T MR scanner. The patients had all been evaluated by a senior psychiatrist on the brief psychiatric rating scale (BPRS). The VBM data was correlated with reports of rate and frequency of hallucinations based on their scores on the BPRS hallucination item. There were significant grey matter volume reductions in the schizophrenia patient group in the left superior (transverse) temporal gyrus, the left middle frontal gyrus, and in the right cuneus. Areas of grey matter volume reduction that correlated negatively with hallucinations were found in the left superior (transverse) temporal gyrus, left thalamus, and left and right cerebellum. This article proposes that significant reductions in grey matter volume may be instrumental in generating spontaneous neuronal activity that is associated with speech perception experiences in the absence of an external acoustic stimulus that may cause hallucinations. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=19020022
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/00207450690962244
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 15
        StartPage: 9
    Subjects:
      – SubjectFull: Hallucinations
        Type: general
      – SubjectFull: People with schizophrenia
        Type: general
      – SubjectFull: Auditory perception
        Type: general
      – SubjectFull: Speech perception
        Type: general
      – SubjectFull: Psychoses
        Type: general
      – SubjectFull: Pathological psychology
        Type: general
    Titles:
      – TitleFull: MR MORPHOMETRY ANALYSIS OF GREY MATTER VOLUME REDUCTION IN SCHIZOPHRENIA: ASSOCIATION WITH HALLUCINATIONS.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: NECKELMANN, GESCHE
      – PersonEntity:
          Name:
            NameFull: SPECHT, KARSTEN
      – PersonEntity:
          Name:
            NameFull: LUND, ANDERS
      – PersonEntity:
          Name:
            NameFull: ERSLAND, LARS
      – PersonEntity:
          Name:
            NameFull: SMIEVOLL, ALF INGE
      – PersonEntity:
          Name:
            NameFull: NECKELMANN, DAG
      – PersonEntity:
          Name:
            NameFull: HUGDAHL, KENNETH
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 01
              Text: Jan2006
              Type: published
              Y: 2006
          Identifiers:
            – Type: issn-print
              Value: 00207454
          Numbering:
            – Type: volume
              Value: 116
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: International Journal of Neuroscience
              Type: main
ResultId 1