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Effect of Regular Exercise on Cognitive Frailty in the Elderly: A Systematic Review.

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Title: Effect of Regular Exercise on Cognitive Frailty in the Elderly: A Systematic Review.
Authors: Ji, Wenting (AUTHOR), Sun, Liwei (AUTHOR), Geng, Qian (AUTHOR), Zheng, Guohua (AUTHOR)
Source: Experimental Aging Research. Jan/Feb2026, Vol. 52 Issue 1, p30-56. 27p.
Subjects: Cognition disorders treatment, Exercise physiology, Independent living, Research funding, Task performance, Therapeutics, Exercise therapy, Frail elderly, Executive function, Cognitive processing speed, Exercise video games, Mindfulness, Descriptive statistics, Functional status, Diagnosis, Gait in humans, Exercise intensity, Tai chi, Systematic reviews, MEDLINE, Resistance training, Medical databases, Quality of life, Aerobic exercises, Online information services, Confidence intervals, Data analysis software, Psychological tests, Body movement, Walking speed, Psychosocial factors, Physical activity, Phenotypes, Postural balance, Grip strength, Active aging, Old age
Geographic Terms: China
Abstract: Objectives: As one of the common senile syndromes characterized by the co-existence of physical frailty and cognitive impairment without dementia, the occurrence of cognitive frailty (CF) increases the risk of adverse health outcomes in older adults. However, its reversibility has attracted the interest of researchers in the search for effective interventions. A growing number of studies have been conducted to investigate the effect of regular physical exercise intervention on cognitive frailty in older adults with CF, but findings remain inconclusive. This study aimed to synthesize the pooled effect of current regular exercise intervention in community-dwelling older adults with cognitive frailty. Methods: Nine electronic databases (Cochrane Library, PubMed, EBSCOHost, Web of Science, Scopus, CNKI, Wanfang Database, VIP and SinoMed) were searched from their inception to 15 May, 2024. The Cochrane risk-of-bias tool (ROB 2) for RCTs was applied to assess the methodological quality. The mean difference or standardized mean difference with 95% CIs was calculated by using Stata 18.0. Results: Seventeen eligible studies involving a total of 2239 participants were included. The pooled results showed that older adults with CF in the intervention group had significant improvement in global cognitive function performance (MMSE scores: MD = 1.93 95% CI: 1.02 to 2.85, p <.0001, and MoCA scores: MD = 3.24, 95% CI: 1.57 to 4.91, p <.0001), executive function (time of TMT-B test: MD = -20.73, 95% CI: −33.96 to −7.50, p =.002), physical frailty state (Fried frailty phenotype scores: MD = -1.48, 95% CI: -2.37 to −0.58, p =.001, and EFS scores: MD = −0.81 points, 95% CI: -1.13 to −0.49, p <.0001), grip strength (SMD = 0.92, 95% CI: 0.15 to 1.07, p =.02), gait and balance (time of TUG: MD = −2.62, 95% CI: −4.12 to −1.11, p =.001), balance (BBS scores: MD = 8.56, 95% CI:- 3.37 to 13.75, p =.001) and quality of life (SMD = 0.75, 95% CI: 0.30 to 1.21, p =.001). Conclusions: More than eight weeks of regular exercise interventions may improve global cognitive function and physical frailty status, but the effect on specific domains of cognitive or physical function needs further study to confirm. [ABSTRACT FROM AUTHOR]
Copyright of Experimental Aging Research is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Effect of Regular Exercise on Cognitive Frailty in the Elderly: A Systematic Review.
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  Data: Objectives: As one of the common senile syndromes characterized by the co-existence of physical frailty and cognitive impairment without dementia, the occurrence of cognitive frailty (CF) increases the risk of adverse health outcomes in older adults. However, its reversibility has attracted the interest of researchers in the search for effective interventions. A growing number of studies have been conducted to investigate the effect of regular physical exercise intervention on cognitive frailty in older adults with CF, but findings remain inconclusive. This study aimed to synthesize the pooled effect of current regular exercise intervention in community-dwelling older adults with cognitive frailty. Methods: Nine electronic databases (Cochrane Library, PubMed, EBSCOHost, Web of Science, Scopus, CNKI, Wanfang Database, VIP and SinoMed) were searched from their inception to 15 May, 2024. The Cochrane risk-of-bias tool (ROB 2) for RCTs was applied to assess the methodological quality. The mean difference or standardized mean difference with 95% CIs was calculated by using Stata 18.0. Results: Seventeen eligible studies involving a total of 2239 participants were included. The pooled results showed that older adults with CF in the intervention group had significant improvement in global cognitive function performance (MMSE scores: MD = 1.93 95% CI: 1.02 to 2.85, p &lt;.0001, and MoCA scores: MD = 3.24, 95% CI: 1.57 to 4.91, p &lt;.0001), executive function (time of TMT-B test: MD = -20.73, 95% CI: −33.96 to −7.50, p =.002), physical frailty state (Fried frailty phenotype scores: MD = -1.48, 95% CI: -2.37 to −0.58, p =.001, and EFS scores: MD = −0.81 points, 95% CI: -1.13 to −0.49, p &lt;.0001), grip strength (SMD = 0.92, 95% CI: 0.15 to 1.07, p =.02), gait and balance (time of TUG: MD = −2.62, 95% CI: −4.12 to −1.11, p =.001), balance (BBS scores: MD = 8.56, 95% CI:- 3.37 to 13.75, p =.001) and quality of life (SMD = 0.75, 95% CI: 0.30 to 1.21, p =.001). Conclusions: More than eight weeks of regular exercise interventions may improve global cognitive function and physical frailty status, but the effect on specific domains of cognitive or physical function needs further study to confirm. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Experimental Aging Research is the property of Taylor &amp; Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/0361073X.2025.2485619
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 27
        StartPage: 30
    Subjects:
      – SubjectFull: Cognition disorders treatment
        Type: general
      – SubjectFull: Exercise physiology
        Type: general
      – SubjectFull: Independent living
        Type: general
      – SubjectFull: Research funding
        Type: general
      – SubjectFull: Task performance
        Type: general
      – SubjectFull: Therapeutics
        Type: general
      – SubjectFull: Exercise therapy
        Type: general
      – SubjectFull: Frail elderly
        Type: general
      – SubjectFull: Executive function
        Type: general
      – SubjectFull: Cognitive processing speed
        Type: general
      – SubjectFull: Exercise video games
        Type: general
      – SubjectFull: Mindfulness
        Type: general
      – SubjectFull: Descriptive statistics
        Type: general
      – SubjectFull: Functional status
        Type: general
      – SubjectFull: Diagnosis
        Type: general
      – SubjectFull: Gait in humans
        Type: general
      – SubjectFull: Exercise intensity
        Type: general
      – SubjectFull: Tai chi
        Type: general
      – SubjectFull: Systematic reviews
        Type: general
      – SubjectFull: MEDLINE
        Type: general
      – SubjectFull: Resistance training
        Type: general
      – SubjectFull: Medical databases
        Type: general
      – SubjectFull: Quality of life
        Type: general
      – SubjectFull: Aerobic exercises
        Type: general
      – SubjectFull: Online information services
        Type: general
      – SubjectFull: Confidence intervals
        Type: general
      – SubjectFull: Data analysis software
        Type: general
      – SubjectFull: Psychological tests
        Type: general
      – SubjectFull: Body movement
        Type: general
      – SubjectFull: Walking speed
        Type: general
      – SubjectFull: Psychosocial factors
        Type: general
      – SubjectFull: Physical activity
        Type: general
      – SubjectFull: Phenotypes
        Type: general
      – SubjectFull: Postural balance
        Type: general
      – SubjectFull: Grip strength
        Type: general
      – SubjectFull: Active aging
        Type: general
      – SubjectFull: Old age
        Type: general
      – SubjectFull: China
        Type: general
    Titles:
      – TitleFull: Effect of Regular Exercise on Cognitive Frailty in the Elderly: A Systematic Review.
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            NameFull: Ji, Wenting
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            – D: 01
              M: 01
              Text: Jan/Feb2026
              Type: published
              Y: 2026
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