View in EDS HTML Full Text PDF Full Text

The effect of low-dose esketamine on maternal depression after cesarean delivery.

Saved in:
Bibliographic Details
Title: The effect of low-dose esketamine on maternal depression after cesarean delivery.
Authors: Shang, Yan (AUTHOR), Li, Siyuan (AUTHOR), Zheng, Qin (AUTHOR), Mi, Tingting (AUTHOR), Lv, Yuzhu (AUTHOR), Han, Lichun (AUTHOR), Wang, Binrong (AUTHOR)
Source: Journal of Psychosomatic Obstetrics & Gynecology. Dec2025, Vol. 46 Issue 1, p1-14. 14p.
Subjects: Postpartum depression, Edinburgh Postnatal Depression Scale, Clinical trials, Depression in women, Adverse health care events, Cesarean section, Intravenous therapy
Abstract: Objective: To assess the impact of low-dose intravenous esketamine on postpartum depression scores in women undergoing cesarean section. Methods: In a randomized, double-blind, placebo-controlled trial, 186 women aged 20–50 years receiving epidural anesthesia for cesarean section were divided into three groups: Group A (0.25 mg/kg esketamine intraoperatively + esketamine in PCIA), Group B (0.25 mg/kg esketamine intraoperatively + PCIA without esketamine), and Group C (placebo intraoperatively + PCIA without esketamine). The primary outcome was the change in Edinburgh Postnatal Depression Scale (EPDS) scores. Secondary outcomes included Pittsburgh Sleep Quality Index (PSQI) scores, Visual Analogue Scale (VAS) scores, PCIA bolus frequency, and adverse events. Results: EPDS and PSQI scores decreased significantly post-surgery across all groups (p < 0.05). Groups A and B showed greater EPDS score reductions than Group C at 5, 7 and 14 days postoperatively (p < 0.01). No significant differences were observed in PSQI scores, VAS scores or PCIA bolus frequency between groups. Adverse events though mild and transient, were more frequent in Group A (p < 0.01). Conclusion: Low-dose intravenous esketamine, reduces postpartum depression scores post-cesarean section, with a safe profile despite increased mild adverse events when combined with PCIA. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Psychosomatic Obstetrics & Gynecology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 190350977
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: The effect of low-dose esketamine on maternal depression after cesarean delivery.
– Name: Author
  Label: Authors
  Group: Au
  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Shang%2C+Yan%22&quot;&gt;Shang, Yan&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Li%2C+Siyuan%22&quot;&gt;Li, Siyuan&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Zheng%2C+Qin%22&quot;&gt;Zheng, Qin&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Mi%2C+Tingting%22&quot;&gt;Mi, Tingting&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Lv%2C+Yuzhu%22&quot;&gt;Lv, Yuzhu&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Han%2C+Lichun%22&quot;&gt;Han, Lichun&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Wang%2C+Binrong%22&quot;&gt;Wang, Binrong&lt;/searchLink&gt; (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Journal+of+Psychosomatic+Obstetrics+%26+Gynecology%22&quot;&gt;Journal of Psychosomatic Obstetrics &amp; Gynecology&lt;/searchLink&gt;. Dec2025, Vol. 46 Issue 1, p1-14. 14p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Postpartum+depression%22&quot;&gt;Postpartum depression&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Edinburgh+Postnatal+Depression+Scale%22&quot;&gt;Edinburgh Postnatal Depression Scale&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Clinical+trials%22&quot;&gt;Clinical trials&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Depression+in+women%22&quot;&gt;Depression in women&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Adverse+health+care+events%22&quot;&gt;Adverse health care events&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Cesarean+section%22&quot;&gt;Cesarean section&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Intravenous+therapy%22&quot;&gt;Intravenous therapy&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective: To assess the impact of low-dose intravenous esketamine on postpartum depression scores in women undergoing cesarean section. Methods: In a randomized, double-blind, placebo-controlled trial, 186 women aged 20–50 years receiving epidural anesthesia for cesarean section were divided into three groups: Group A (0.25 mg/kg esketamine intraoperatively + esketamine in PCIA), Group B (0.25 mg/kg esketamine intraoperatively + PCIA without esketamine), and Group C (placebo intraoperatively + PCIA without esketamine). The primary outcome was the change in Edinburgh Postnatal Depression Scale (EPDS) scores. Secondary outcomes included Pittsburgh Sleep Quality Index (PSQI) scores, Visual Analogue Scale (VAS) scores, PCIA bolus frequency, and adverse events. Results: EPDS and PSQI scores decreased significantly post-surgery across all groups (p &lt; 0.05). Groups A and B showed greater EPDS score reductions than Group C at 5, 7 and 14 days postoperatively (p &lt; 0.01). No significant differences were observed in PSQI scores, VAS scores or PCIA bolus frequency between groups. Adverse events though mild and transient, were more frequent in Group A (p &lt; 0.01). Conclusion: Low-dose intravenous esketamine, reduces postpartum depression scores post-cesarean section, with a safe profile despite increased mild adverse events when combined with PCIA. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: &lt;i&gt;Copyright of Journal of Psychosomatic Obstetrics &amp; Gynecology is the property of Taylor &amp; Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=190350977
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/0167482X.2025.2527659
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 14
        StartPage: 1
    Subjects:
      – SubjectFull: Postpartum depression
        Type: general
      – SubjectFull: Edinburgh Postnatal Depression Scale
        Type: general
      – SubjectFull: Clinical trials
        Type: general
      – SubjectFull: Depression in women
        Type: general
      – SubjectFull: Adverse health care events
        Type: general
      – SubjectFull: Cesarean section
        Type: general
      – SubjectFull: Intravenous therapy
        Type: general
    Titles:
      – TitleFull: The effect of low-dose esketamine on maternal depression after cesarean delivery.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Shang, Yan
      – PersonEntity:
          Name:
            NameFull: Li, Siyuan
      – PersonEntity:
          Name:
            NameFull: Zheng, Qin
      – PersonEntity:
          Name:
            NameFull: Mi, Tingting
      – PersonEntity:
          Name:
            NameFull: Lv, Yuzhu
      – PersonEntity:
          Name:
            NameFull: Han, Lichun
      – PersonEntity:
          Name:
            NameFull: Wang, Binrong
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 12
              Text: Dec2025
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-print
              Value: 0167482X
          Numbering:
            – Type: volume
              Value: 46
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Journal of Psychosomatic Obstetrics & Gynecology
              Type: main
ResultId 1