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Meta-analysis of the association between gut microbiota and postpartum depression.

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Title: Meta-analysis of the association between gut microbiota and postpartum depression.
Authors: Guo, Yan (AUTHOR), Chen, Wangxiang (AUTHOR)
Source: Journal of Psychosomatic Obstetrics & Gynecology. Dec2025, Vol. 46 Issue 1, p1-19. 19p.
Subjects: Gut microbiota, Postpartum depression, Inflammation, Disease risk factors, Aggregation (Statistics), Protective factors, Neurotransmitters
Abstract: Objective: This study aimed to explore the association between gut microbiota and postpartum depression (PPD) through meta-analysis, providing a basis for effective clinical preventive interventions.​ Methods: Systematic searches were conducted in English databases (Cochrane Library, Embase, Web of Science, PubMed) for studies published up to April 2025. Literature screening used a double-blind method, and quality assessment was performed with the AHRQ methodological tool evaluating 11 core dimensions. Meta-analysis was conducted using STATA 18.0 software on eligible studies. Results: Twelve studies were included. α-Proteobacteria was a significant risk factor for PPD (OR = 1.19, 95%CI: 1.11–1.28, p < 0.05). Protective factors included Bifidobacterium (OR = 0.82), Ruminococcaceae (OR = 0.88), Prevotellaceae (OR = 0.89), Veillonellaceae (OR = 0.83), and Clostridia (OR = 0.84). Included studies showed low heterogeneity, with robust results and low publication bias risk. Conclusion: PPD is closely linked to specific gut microbiota imbalances. α-Proteobacteria may increase PPD risk via inflammatory responses, while beneficial microbiota exert protective effects through neurotransmitter regulation, short-chain fatty acid metabolism, and gut-brain axis modulation. Gut microbiota could serve as a target for PPD intervention and prevention. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Psychosomatic Obstetrics & Gynecology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Meta-analysis of the association between gut microbiota and postpartum depression.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Guo%2C+Yan%22&quot;&gt;Guo, Yan&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Chen%2C+Wangxiang%22&quot;&gt;Chen, Wangxiang&lt;/searchLink&gt; (AUTHOR)
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– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective: This study aimed to explore the association between gut microbiota and postpartum depression (PPD) through meta-analysis, providing a basis for effective clinical preventive interventions.​ Methods: Systematic searches were conducted in English databases (Cochrane Library, Embase, Web of Science, PubMed) for studies published up to April 2025. Literature screening used a double-blind method, and quality assessment was performed with the AHRQ methodological tool evaluating 11 core dimensions. Meta-analysis was conducted using STATA 18.0 software on eligible studies. Results: Twelve studies were included. α-Proteobacteria was a significant risk factor for PPD (OR = 1.19, 95%CI: 1.11–1.28, p &lt; 0.05). Protective factors included Bifidobacterium (OR = 0.82), Ruminococcaceae (OR = 0.88), Prevotellaceae (OR = 0.89), Veillonellaceae (OR = 0.83), and Clostridia (OR = 0.84). Included studies showed low heterogeneity, with robust results and low publication bias risk. Conclusion: PPD is closely linked to specific gut microbiota imbalances. α-Proteobacteria may increase PPD risk via inflammatory responses, while beneficial microbiota exert protective effects through neurotransmitter regulation, short-chain fatty acid metabolism, and gut-brain axis modulation. Gut microbiota could serve as a target for PPD intervention and prevention. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: &lt;i&gt;Copyright of Journal of Psychosomatic Obstetrics &amp; Gynecology is the property of Taylor &amp; Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1080/0167482X.2025.2548567
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      – Code: eng
        Text: English
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        PageCount: 19
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    Subjects:
      – SubjectFull: Gut microbiota
        Type: general
      – SubjectFull: Postpartum depression
        Type: general
      – SubjectFull: Inflammation
        Type: general
      – SubjectFull: Disease risk factors
        Type: general
      – SubjectFull: Aggregation (Statistics)
        Type: general
      – SubjectFull: Protective factors
        Type: general
      – SubjectFull: Neurotransmitters
        Type: general
    Titles:
      – TitleFull: Meta-analysis of the association between gut microbiota and postpartum depression.
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            NameFull: Guo, Yan
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            NameFull: Chen, Wangxiang
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          Dates:
            – D: 01
              M: 12
              Text: Dec2025
              Type: published
              Y: 2025
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