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Child Mental Health Research in Low- and Middle-Income Countries: A Twin-Family Feasibility Study in Nigeria.

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Title: Child Mental Health Research in Low- and Middle-Income Countries: A Twin-Family Feasibility Study in Nigeria.
Authors: Oginni, Olakunle Ayokunmi (AUTHOR), Oguns, Olatokunbo (AUTHOR), Jeje, Olusola (AUTHOR), Olorumoteni, Oluwatosin (AUTHOR), Mapayi, Boladale (AUTHOR), Gilbert, Ruth (AUTHOR), Stein, Dan J. (AUTHOR), Rijsdijk, Frühling (AUTHOR), Thapar, Anita (AUTHOR)
Source: Behavior Genetics. Nov2025, Vol. 55 Issue 6, p438-453. 16p.
Subjects: Low-income countries, Twin studies, Feasibility studies, Sampling methods, Nigerians, Child mental health services, Psychiatrists, Stakeholder analysis
Geographic Terms: Africa, Southwest Nigeria, Nigeria
Abstract: Globally, most children and adolescents live in low- and middle-income (LAMI) countries. Despite the high and under-recognized mental health burden in these settings, there is little systematic research to inform cost-effective mental health interventions. Identifying causal risk and protective mechanisms is important to inform such interventions. Longitudinal genetically informative designs can help identify potentially causal environmental mechanisms in the etiology of childhood psychopathology but few have been carried out in LAMI settings. We tested the feasibility of a twin-family study in a semi-urban setting in South-Western Nigeria. We recruited 320 family units, each comprising at least one parent and both twins aged 2.5–5.9 (x̄ = 4.0 ± 0.92) years from two towns using five strategies: direct and indirect contacts, radio adverts, cluster sampling (based on local administrative units) and snowball sampling. Participants were asked about their willingness to participate in future research including providing biological samples. These were supplemented with participant engagement activities before and after data collection. Snowball sampling was the most effective strategy while cluster sampling was the least effective (recruiting 46.3% and 8.3% of participants, respectively). Direct contacts and cluster sampling appeared prone to excluding under-represented participants. A large proportion of the participants (98–99%) were willing to participate in future studies. Challenges included grant administration (finance and ethical priorities) and desirability bias. Twin research is feasible in LAMI sub-Saharan Africa, with snowball sampling being an efficient means of recruiting a diverse sample. Participant involvement and engagement is useful to inform the execution of genetically-informative research in a LAMI context. [ABSTRACT FROM AUTHOR]
Copyright of Behavior Genetics is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Child Mental Health Research in Low- and Middle-Income Countries: A Twin-Family Feasibility Study in Nigeria.
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  Data: <searchLink fieldCode="AR" term="%22Oginni%2C+Olakunle+Ayokunmi%22">Oginni, Olakunle Ayokunmi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Oguns%2C+Olatokunbo%22">Oguns, Olatokunbo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jeje%2C+Olusola%22">Jeje, Olusola</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Olorumoteni%2C+Oluwatosin%22">Olorumoteni, Oluwatosin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mapayi%2C+Boladale%22">Mapayi, Boladale</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gilbert%2C+Ruth%22">Gilbert, Ruth</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Stein%2C+Dan+J%2E%22">Stein, Dan J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rijsdijk%2C+Frühling%22">Rijsdijk, Frühling</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Thapar%2C+Anita%22">Thapar, Anita</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Behavior+Genetics%22">Behavior Genetics</searchLink>. Nov2025, Vol. 55 Issue 6, p438-453. 16p.
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  Data: <searchLink fieldCode="DE" term="%22Low-income+countries%22">Low-income countries</searchLink><br /><searchLink fieldCode="DE" term="%22Twin+studies%22">Twin studies</searchLink><br /><searchLink fieldCode="DE" term="%22Feasibility+studies%22">Feasibility studies</searchLink><br /><searchLink fieldCode="DE" term="%22Sampling+methods%22">Sampling methods</searchLink><br /><searchLink fieldCode="DE" term="%22Nigerians%22">Nigerians</searchLink><br /><searchLink fieldCode="DE" term="%22Child+mental+health+services%22">Child mental health services</searchLink><br /><searchLink fieldCode="DE" term="%22Psychiatrists%22">Psychiatrists</searchLink><br /><searchLink fieldCode="DE" term="%22Stakeholder+analysis%22">Stakeholder analysis</searchLink>
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  Label: Geographic Terms
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  Data: <searchLink fieldCode="DE" term="%22Africa%22">Africa</searchLink><br /><searchLink fieldCode="DE" term="%22Southwest+Nigeria%22">Southwest Nigeria</searchLink><br /><searchLink fieldCode="DE" term="%22Nigeria%22">Nigeria</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Globally, most children and adolescents live in low- and middle-income (LAMI) countries. Despite the high and under-recognized mental health burden in these settings, there is little systematic research to inform cost-effective mental health interventions. Identifying causal risk and protective mechanisms is important to inform such interventions. Longitudinal genetically informative designs can help identify potentially causal environmental mechanisms in the etiology of childhood psychopathology but few have been carried out in LAMI settings. We tested the feasibility of a twin-family study in a semi-urban setting in South-Western Nigeria. We recruited 320 family units, each comprising at least one parent and both twins aged 2.5–5.9 (x̄ = 4.0 ± 0.92) years from two towns using five strategies: direct and indirect contacts, radio adverts, cluster sampling (based on local administrative units) and snowball sampling. Participants were asked about their willingness to participate in future research including providing biological samples. These were supplemented with participant engagement activities before and after data collection. Snowball sampling was the most effective strategy while cluster sampling was the least effective (recruiting 46.3% and 8.3% of participants, respectively). Direct contacts and cluster sampling appeared prone to excluding under-represented participants. A large proportion of the participants (98–99%) were willing to participate in future studies. Challenges included grant administration (finance and ethical priorities) and desirability bias. Twin research is feasible in LAMI sub-Saharan Africa, with snowball sampling being an efficient means of recruiting a diverse sample. Participant involvement and engagement is useful to inform the execution of genetically-informative research in a LAMI context. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Behavior Genetics is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=190380471
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        Value: 10.1007/s10519-025-10235-z
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      – Code: eng
        Text: English
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        PageCount: 16
        StartPage: 438
    Subjects:
      – SubjectFull: Low-income countries
        Type: general
      – SubjectFull: Twin studies
        Type: general
      – SubjectFull: Feasibility studies
        Type: general
      – SubjectFull: Sampling methods
        Type: general
      – SubjectFull: Nigerians
        Type: general
      – SubjectFull: Child mental health services
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      – SubjectFull: Psychiatrists
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      – SubjectFull: Stakeholder analysis
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      – SubjectFull: Africa
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      – SubjectFull: Southwest Nigeria
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      – SubjectFull: Nigeria
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              Text: Nov2025
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