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White matter microstructure of the cingulum bundle and the uncinate fasciculus in primary and secondary callous-unemotional traits.

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Title: White matter microstructure of the cingulum bundle and the uncinate fasciculus in primary and secondary callous-unemotional traits.
Authors: Schalk, Luisa (AUTHOR), Sethi, Arjun (AUTHOR), Saam, Melanie C. (AUTHOR), Flamarique, Itziar (AUTHOR), Naaijen, Jilly (AUTHOR), Dietrich, Andrea (AUTHOR), Hoekstra, Pieter J. (AUTHOR), Banaschewski, Tobias (AUTHOR), Aggensteiner, Pascal-M (AUTHOR), Holz, Nathalie (AUTHOR), Baumeister, Sarah (AUTHOR), Borràs, Roger (AUTHOR), Rosa-Justicia, Mireia (AUTHOR), Santosh, Paramala (AUTHOR), Sagar-Ouriaghli, Ilyas (AUTHOR), Arango, Celso (AUTHOR), José Penzol, María (AUTHOR), Brandeis, Daniel (AUTHOR), Walitza, Susanne (AUTHOR), Werhahn, Julia E. (AUTHOR)
Source: European Child & Adolescent Psychiatry. Dec2025, Vol. 34 Issue 12, p4035-4051. 17p.
Subjects: Behavior disorders, Cross-sectional method, Functional connectivity, Research funding, Data analysis, Nerve fibers, Brain, Neural development, Interviewing, Magnetic resonance imaging, Internalizing behavior, Descriptive statistics, Anisotropy, Behavior disorders in children, Teenagers' conduct of life, White matter (Nerve tissue), Frontal lobe, Research, Personality, Statistics, Research methodology, Neuroradiology, Data analysis software, Child behavior, Sensitivity & specificity (Statistics), Antisocial personality disorders, Fluorimetry
Abstract: Callous-unemotional (CU) traits appear to be linked to differences in neural networks, including the uncinate fasciculus (UF) and cingulum bundle (CB). It has recently been suggested that CU traits are comprised of primary and secondary subtypes based on the relative co-occurrence of internalising symptoms. Here, we explored the white matter microstructure of these subtypes. White matter microstructure of the UF and CB was analysed in youths (aged 8–18; n = 121; females = 31) recruited through Europe-based multisite studies. Our sample comprised a control (n = 53) and a case group with disruptive behaviour disorders (DBDs) (n = 68) with low and high levels of CU traits. The case group was further split into primary (n = 49) and secondary (n = 14) subgroups. Compared to the control group, the case group showed decreased mean diffusivity in the right ventral CB (p =.023, uncorrected). Within our case group, higher scores on the 'unemotional' subscale of the Inventory of Callous Unemotional Traits were associated with decreased axial diffusivity (p =.02, uncorrected) and mean diffusivity (p =.013, uncorrected) in the dorsal CB in youths with primary CU traits, but the opposite in those with secondary CU traits. Post hoc analyses found that the left hemisphere drove these effects. The relationship between CU traits and dorsal CB microstructure appears dependent on the presence of internalising symptoms and CU traits subcomponents. A fractionation may lead to a better understanding of the aetiology of DBDs and more focused treatment options. [ABSTRACT FROM AUTHOR]
Copyright of European Child & Adolescent Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: White matter microstructure of the cingulum bundle and the uncinate fasciculus in primary and secondary callous-unemotional traits.
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  Data: <searchLink fieldCode="JN" term="%22European+Child+%26+Adolescent+Psychiatry%22">European Child & Adolescent Psychiatry</searchLink>. Dec2025, Vol. 34 Issue 12, p4035-4051. 17p.
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  Data: Callous-unemotional (CU) traits appear to be linked to differences in neural networks, including the uncinate fasciculus (UF) and cingulum bundle (CB). It has recently been suggested that CU traits are comprised of primary and secondary subtypes based on the relative co-occurrence of internalising symptoms. Here, we explored the white matter microstructure of these subtypes. White matter microstructure of the UF and CB was analysed in youths (aged 8–18; n = 121; females = 31) recruited through Europe-based multisite studies. Our sample comprised a control (n = 53) and a case group with disruptive behaviour disorders (DBDs) (n = 68) with low and high levels of CU traits. The case group was further split into primary (n = 49) and secondary (n = 14) subgroups. Compared to the control group, the case group showed decreased mean diffusivity in the right ventral CB (p =.023, uncorrected). Within our case group, higher scores on the 'unemotional' subscale of the Inventory of Callous Unemotional Traits were associated with decreased axial diffusivity (p =.02, uncorrected) and mean diffusivity (p =.013, uncorrected) in the dorsal CB in youths with primary CU traits, but the opposite in those with secondary CU traits. Post hoc analyses found that the left hemisphere drove these effects. The relationship between CU traits and dorsal CB microstructure appears dependent on the presence of internalising symptoms and CU traits subcomponents. A fractionation may lead to a better understanding of the aetiology of DBDs and more focused treatment options. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Child & Adolescent Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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