Investigation of Genetic Variants in Antioxidant Enzymes (SOD2 rs4880, CAT rs1001179) and Their Association With Clinical Phenotypes of Multiple Sclerosis: A Case–Control Study.
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| Title: | Investigation of Genetic Variants in Antioxidant Enzymes (SOD2 rs4880, CAT rs1001179) and Their Association With Clinical Phenotypes of Multiple Sclerosis: A Case–Control Study. |
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| Authors: | Siokas, Vasileios (AUTHOR), Raptis, Athanasios E. P. (AUTHOR), Karagiorgou, Lamprini (AUTHOR), Katsarou, Martha-Spyridoula (AUTHOR), Liampas, Ioannis (AUTHOR), Marogianni, Chrysa (AUTHOR), Tsolakou, Annia (AUTHOR), Tsatsakis, Aristidis (AUTHOR), Drakoulis, Nikolaos (AUTHOR), Dardiotis, Efthimios (AUTHOR), Papasavva, Maria (AUTHOR), Fee, Dominic B. (AUTHOR) |
| Source: | Acta Neurologica Scandinavica. 12/28/2025, Vol. 2025, p1-10. 10p. |
| Subjects: | Multiple sclerosis, Genetic variation, Oxidative stress, Phenotypes, Antioxidants, Case-control method |
| Abstract: | Background: Multiple sclerosis (MS) is a chronic, autoimmune disease of the central nervous system with both environmental and genetic inputs. Oxidative stress (OS) seems to be implicated in MS pathophysiology via various mechanisms, including promotion of inflammation, demyelination, and neurodegeneration. Objective: The aim of the current study was to investigate the potential association of two common genetic variants in antioxidant enzymes, namely SOD2 rs4880 and CAT rs1001179, with MS susceptibility and distinct MS clinical features. Methods: A case–control study was conducted, including 200 clinically diagnosed patients with MS and 265 healthy controls, with no neurological background, from Greece. DNA was extracted and genotyping of the two variants, SOD2 rs4880 and CAT rs1001179, was performed using the Competitive Allele‐Specific PCR (KASP) assay. Results: No statistically significant differences were found in genotype or allele frequency distributions between patients with MS and controls for these two investigated variants. However, in subgroup analyses that followed, potential associations were observed between SOD2 rs4880 and CAT rs1001179 and specific clinical features in the MS cohort, including motor and sensory symptoms and the existence of spinal cord lesions. Conclusion: While no association was found between the studied variants and MS susceptibility in general, the findings suggest a possible involvement of SOD2 rs4880 and CAT rs1001179 variants in shaping MS clinical variability. Further larger scale studies in independent populations are needed in order to understand the exact role of antioxidant enzyme variability in MS. [ABSTRACT FROM AUTHOR] |
| Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 190548042 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Investigation of Genetic Variants in Antioxidant Enzymes (SOD2 rs4880, CAT rs1001179) and Their Association With Clinical Phenotypes of Multiple Sclerosis: A Case–Control Study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Siokas%2C+Vasileios%22">Siokas, Vasileios</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Raptis%2C+Athanasios+E%2E+P%2E%22">Raptis, Athanasios E. P.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Karagiorgou%2C+Lamprini%22">Karagiorgou, Lamprini</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Katsarou%2C+Martha-Spyridoula%22">Katsarou, Martha-Spyridoula</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liampas%2C+Ioannis%22">Liampas, Ioannis</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Marogianni%2C+Chrysa%22">Marogianni, Chrysa</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tsolakou%2C+Annia%22">Tsolakou, Annia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tsatsakis%2C+Aristidis%22">Tsatsakis, Aristidis</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Drakoulis%2C+Nikolaos%22">Drakoulis, Nikolaos</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dardiotis%2C+Efthimios%22">Dardiotis, Efthimios</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Papasavva%2C+Maria%22">Papasavva, Maria</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fee%2C+Dominic+B%2E%22">Fee, Dominic B.</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Acta+Neurologica+Scandinavica%22">Acta Neurologica Scandinavica</searchLink>. 12/28/2025, Vol. 2025, p1-10. 10p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Multiple+sclerosis%22">Multiple sclerosis</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+variation%22">Genetic variation</searchLink><br /><searchLink fieldCode="DE" term="%22Oxidative+stress%22">Oxidative stress</searchLink><br /><searchLink fieldCode="DE" term="%22Phenotypes%22">Phenotypes</searchLink><br /><searchLink fieldCode="DE" term="%22Antioxidants%22">Antioxidants</searchLink><br /><searchLink fieldCode="DE" term="%22Case-control+method%22">Case-control method</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background: Multiple sclerosis (MS) is a chronic, autoimmune disease of the central nervous system with both environmental and genetic inputs. Oxidative stress (OS) seems to be implicated in MS pathophysiology via various mechanisms, including promotion of inflammation, demyelination, and neurodegeneration. Objective: The aim of the current study was to investigate the potential association of two common genetic variants in antioxidant enzymes, namely SOD2 rs4880 and CAT rs1001179, with MS susceptibility and distinct MS clinical features. Methods: A case–control study was conducted, including 200 clinically diagnosed patients with MS and 265 healthy controls, with no neurological background, from Greece. DNA was extracted and genotyping of the two variants, SOD2 rs4880 and CAT rs1001179, was performed using the Competitive Allele‐Specific PCR (KASP) assay. Results: No statistically significant differences were found in genotype or allele frequency distributions between patients with MS and controls for these two investigated variants. However, in subgroup analyses that followed, potential associations were observed between SOD2 rs4880 and CAT rs1001179 and specific clinical features in the MS cohort, including motor and sensory symptoms and the existence of spinal cord lesions. Conclusion: While no association was found between the studied variants and MS susceptibility in general, the findings suggest a possible involvement of SOD2 rs4880 and CAT rs1001179 variants in shaping MS clinical variability. Further larger scale studies in independent populations are needed in order to understand the exact role of antioxidant enzyme variability in MS. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1155/ane/3853574 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 1 Subjects: – SubjectFull: Multiple sclerosis Type: general – SubjectFull: Genetic variation Type: general – SubjectFull: Oxidative stress Type: general – SubjectFull: Phenotypes Type: general – SubjectFull: Antioxidants Type: general – SubjectFull: Case-control method Type: general Titles: – TitleFull: Investigation of Genetic Variants in Antioxidant Enzymes (SOD2 rs4880, CAT rs1001179) and Their Association With Clinical Phenotypes of Multiple Sclerosis: A Case–Control Study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Siokas, Vasileios – PersonEntity: Name: NameFull: Raptis, Athanasios E. P. – PersonEntity: Name: NameFull: Karagiorgou, Lamprini – PersonEntity: Name: NameFull: Katsarou, Martha-Spyridoula – PersonEntity: Name: NameFull: Liampas, Ioannis – PersonEntity: Name: NameFull: Marogianni, Chrysa – PersonEntity: Name: NameFull: Tsolakou, Annia – PersonEntity: Name: NameFull: Tsatsakis, Aristidis – PersonEntity: Name: NameFull: Drakoulis, Nikolaos – PersonEntity: Name: NameFull: Dardiotis, Efthimios – PersonEntity: Name: NameFull: Papasavva, Maria – PersonEntity: Name: NameFull: Fee, Dominic B. IsPartOfRelationships: – BibEntity: Dates: – D: 28 M: 12 Text: 12/28/2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 00016314 Numbering: – Type: volume Value: 2025 Titles: – TitleFull: Acta Neurologica Scandinavica Type: main |
| ResultId | 1 |
