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Independent component analysis of brain network in drug-resistant epilepsy patients with vagus nerve stimulators.

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Title: Independent component analysis of brain network in drug-resistant epilepsy patients with vagus nerve stimulators.
Authors: Zhu, Jin (AUTHOR), Gu, Rui (AUTHOR), Ji, Fan (AUTHOR)
Source: International Journal of Neuroscience. Jan2026, Vol. 136 Issue 1, p77-84. 8p.
Subjects: Default mode network, Vagus nerve stimulation, Frontoparietal network, Independent component analysis, Epilepsy, Neurophysiology, Cerebellar cortex, Functional magnetic resonance imaging
Abstract: Purpose: To investigate the activity of default mode network (DMN), frontoparietal network (FPN) and cerebellar network (CN) in drug-resistant epilepsy (DRE) patients undergoing vagus nerve stimulation (VNS). Methods: Fifteen patients were recruited and underwent resting-state functional magnetic resonance imaging (fMRI) scans. Independent component analysis and paired sample t-tests were used to examine activity changes of DMN, FPN and CN before and after VNS. Results: Compared with preoperative patients, DMN exhibited decreased activity in left cuneus/precuneus, left median cingulate gyrus, left superior/middle occipital gyrus, right superior parietal gyrus, right precentral/postcentral gyrus, right rolandic operculum and right insula, while increased activity was observed in right supramarginal gyrus, left fusiform gyrus, right supplementary motor area, left amygdala, and right inferior frontal gyrus. FPN displayed decreased activity in left cuneus, left anterior cingulate gyrus, right precentral gyrus, left middle/inferior frontal gyrus, right middle frontal gyrus, left superior/middle temporal gyrus, left superior/middle occipital gyrus, and right superior parietal gyrus, but increased activity in right inferior temporal gyrus. CN showed decreased activity in left superior/middle frontal gyrus, right inferior frontal gyrus, left supplementary motor area, left precuneus, left postcentral gyrus, left middle occipital gyrus, right middle temporal gyrus, and left inferior cerebellum, while increased activity was detected in bilateral superior cerebellum and right fusiform gyrus. Conclusions: DMN, FPN and CN exhibited distinct changes in DRE patients following VNS. The suppression or activation of sensorimotor, language, memory and emotion-related regions may represent the underlying neurological mechanisms of VNS. However, the contrasting activity patterns between superior and inferior cerebellum require further investigation. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Independent component analysis of brain network in drug-resistant epilepsy patients with vagus nerve stimulators.
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  Data: <searchLink fieldCode="AR" term="%22Zhu%2C+Jin%22">Zhu, Jin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gu%2C+Rui%22">Gu, Rui</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ji%2C+Fan%22">Ji, Fan</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Neuroscience%22">International Journal of Neuroscience</searchLink>. Jan2026, Vol. 136 Issue 1, p77-84. 8p.
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  Data: <searchLink fieldCode="DE" term="%22Default+mode+network%22">Default mode network</searchLink><br /><searchLink fieldCode="DE" term="%22Vagus+nerve+stimulation%22">Vagus nerve stimulation</searchLink><br /><searchLink fieldCode="DE" term="%22Frontoparietal+network%22">Frontoparietal network</searchLink><br /><searchLink fieldCode="DE" term="%22Independent+component+analysis%22">Independent component analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Epilepsy%22">Epilepsy</searchLink><br /><searchLink fieldCode="DE" term="%22Neurophysiology%22">Neurophysiology</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebellar+cortex%22">Cerebellar cortex</searchLink><br /><searchLink fieldCode="DE" term="%22Functional+magnetic+resonance+imaging%22">Functional magnetic resonance imaging</searchLink>
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  Label: Abstract
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  Data: Purpose: To investigate the activity of default mode network (DMN), frontoparietal network (FPN) and cerebellar network (CN) in drug-resistant epilepsy (DRE) patients undergoing vagus nerve stimulation (VNS). Methods: Fifteen patients were recruited and underwent resting-state functional magnetic resonance imaging (fMRI) scans. Independent component analysis and paired sample t-tests were used to examine activity changes of DMN, FPN and CN before and after VNS. Results: Compared with preoperative patients, DMN exhibited decreased activity in left cuneus/precuneus, left median cingulate gyrus, left superior/middle occipital gyrus, right superior parietal gyrus, right precentral/postcentral gyrus, right rolandic operculum and right insula, while increased activity was observed in right supramarginal gyrus, left fusiform gyrus, right supplementary motor area, left amygdala, and right inferior frontal gyrus. FPN displayed decreased activity in left cuneus, left anterior cingulate gyrus, right precentral gyrus, left middle/inferior frontal gyrus, right middle frontal gyrus, left superior/middle temporal gyrus, left superior/middle occipital gyrus, and right superior parietal gyrus, but increased activity in right inferior temporal gyrus. CN showed decreased activity in left superior/middle frontal gyrus, right inferior frontal gyrus, left supplementary motor area, left precuneus, left postcentral gyrus, left middle occipital gyrus, right middle temporal gyrus, and left inferior cerebellum, while increased activity was detected in bilateral superior cerebellum and right fusiform gyrus. Conclusions: DMN, FPN and CN exhibited distinct changes in DRE patients following VNS. The suppression or activation of sensorimotor, language, memory and emotion-related regions may represent the underlying neurological mechanisms of VNS. However, the contrasting activity patterns between superior and inferior cerebellum require further investigation. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1080/00207454.2024.2449382
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        Text: English
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      – SubjectFull: Default mode network
        Type: general
      – SubjectFull: Vagus nerve stimulation
        Type: general
      – SubjectFull: Frontoparietal network
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      – SubjectFull: Independent component analysis
        Type: general
      – SubjectFull: Epilepsy
        Type: general
      – SubjectFull: Neurophysiology
        Type: general
      – SubjectFull: Cerebellar cortex
        Type: general
      – SubjectFull: Functional magnetic resonance imaging
        Type: general
    Titles:
      – TitleFull: Independent component analysis of brain network in drug-resistant epilepsy patients with vagus nerve stimulators.
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            NameFull: Zhu, Jin
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            – D: 01
              M: 01
              Text: Jan2026
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              Y: 2026
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