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Sleep quality and its correlates in people with epilepsy: A multicenter cross‐sectional study in Germany.

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Title: Sleep quality and its correlates in people with epilepsy: A multicenter cross‐sectional study in Germany.
Authors: Zöllner, Johann Philipp (AUTHOR), Mann, Catrin (AUTHOR), Willems, Laurent (AUTHOR), von Podewils, Felix (AUTHOR), Langenbruch, Lisa (AUTHOR), Bierhansl, Laura (AUTHOR), Knake, Susanne (AUTHOR), Menzler, Katja (AUTHOR), Schulz, Juliane (AUTHOR), Gaida, Bernadette (AUTHOR), Rosenow, Felix (AUTHOR), Strzelczyk, Adam (AUTHOR)
Source: Epilepsia (Series 4). Dec2025, Vol. 66 Issue 12, p4764-4779. 16p.
Subjects: Sleep quality, Epilepsy, Mental depression, Anxiety, Affective disorders, Quality of life, Cross-sectional method
Geographic Terms: Germany
Abstract: Objective: Sleep disturbances and epilepsy are closely interrelated. This study aimed to examine associations between sleep quality, affective symptoms, and quality of life (QoL) in people with epilepsy (PWE), and to identify clinical and sociodemographic factors linked to impaired sleep. Methods: We conducted a multicenter cross‐sectional study of adult PWE across four tertiary epilepsy centers in Germany. We assessed sleep quality using the Pittsburgh Sleep Quality Index (PSQI), affective symptoms with the Hospital Anxiety and Depression Scale (HADS), and epilepsy‐specific QoL with the 31‐item Quality of Life in Epilepsy (QOLIE‐31) inventory. We evaluated sociodemographic and clinical predictors of sleep quality and QoL using univariable and multivariable analyses. Comparisons were made with normative data from the general German population and individuals with chronic migraine. Results: Of 449 individuals (mean age 39.9 years, 58.1% women), 221 (49.2%) were identified as "poor sleepers," significantly exceeding rates in the general population (35.9%, p <.001). In multivariable analysis, poor sleep quality was independently associated with female sex (odds ratio [OR] 2.02, 95% confidence interval [CI] 1.36–3.01, p =.001), unemployment (OR 1.74, 95% CI = 1.10–2.73, p =.017), anxiety (OR = 3.79, 95% CI = 2.39–6.04, p <.001), and depression (OR = 2.19, 95% CI = 1.36–3.54, p =.001). In addition, daily seizures were linked to worse sleep quality (OR = 2.55, 95% CI = 1.03–6.30, p =.042). Poor sleep was independently associated with lower epilepsy‐related QoL after adjusting for affective symptoms and seizure frequency (OR = 1.79, 95% CI = 1.20–2.68, p =.005). Significance: Sleep quality in PWE is significantly impaired and strongly associated with anxiety, depression, and sociodemographic variables in addition to epilepsy‐specific factors. Poor sleep independently correlates with diminished QoL, supporting the value of routine screening for affective symptoms and sleep disturbances in epilepsy care. [ABSTRACT FROM AUTHOR]
Copyright of Epilepsia (Series 4) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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DbLabel: Psychology and Behavioral Sciences Collection
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AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Sleep quality and its correlates in people with epilepsy: A multicenter cross‐sectional study in Germany.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Z&#246;llner%2C+Johann+Philipp%22&quot;&gt;Z&#246;llner, Johann Philipp&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Mann%2C+Catrin%22&quot;&gt;Mann, Catrin&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Willems%2C+Laurent%22&quot;&gt;Willems, Laurent&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22von+Podewils%2C+Felix%22&quot;&gt;von Podewils, Felix&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Langenbruch%2C+Lisa%22&quot;&gt;Langenbruch, Lisa&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Bierhansl%2C+Laura%22&quot;&gt;Bierhansl, Laura&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Knake%2C+Susanne%22&quot;&gt;Knake, Susanne&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Menzler%2C+Katja%22&quot;&gt;Menzler, Katja&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Schulz%2C+Juliane%22&quot;&gt;Schulz, Juliane&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Gaida%2C+Bernadette%22&quot;&gt;Gaida, Bernadette&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Rosenow%2C+Felix%22&quot;&gt;Rosenow, Felix&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Strzelczyk%2C+Adam%22&quot;&gt;Strzelczyk, Adam&lt;/searchLink&gt; (AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Epilepsia+%28Series+4%29%22&quot;&gt;Epilepsia (Series 4)&lt;/searchLink&gt;. Dec2025, Vol. 66 Issue 12, p4764-4779. 16p.
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  Data: Objective: Sleep disturbances and epilepsy are closely interrelated. This study aimed to examine associations between sleep quality, affective symptoms, and quality of life (QoL) in people with epilepsy (PWE), and to identify clinical and sociodemographic factors linked to impaired sleep. Methods: We conducted a multicenter cross‐sectional study of adult PWE across four tertiary epilepsy centers in Germany. We assessed sleep quality using the Pittsburgh Sleep Quality Index (PSQI), affective symptoms with the Hospital Anxiety and Depression Scale (HADS), and epilepsy‐specific QoL with the 31‐item Quality of Life in Epilepsy (QOLIE‐31) inventory. We evaluated sociodemographic and clinical predictors of sleep quality and QoL using univariable and multivariable analyses. Comparisons were made with normative data from the general German population and individuals with chronic migraine. Results: Of 449 individuals (mean age 39.9 years, 58.1% women), 221 (49.2%) were identified as &quot;poor sleepers,&quot; significantly exceeding rates in the general population (35.9%, p &lt;.001). In multivariable analysis, poor sleep quality was independently associated with female sex (odds ratio [OR] 2.02, 95% confidence interval [CI] 1.36–3.01, p =.001), unemployment (OR 1.74, 95% CI = 1.10–2.73, p =.017), anxiety (OR = 3.79, 95% CI = 2.39–6.04, p &lt;.001), and depression (OR = 2.19, 95% CI = 1.36–3.54, p =.001). In addition, daily seizures were linked to worse sleep quality (OR = 2.55, 95% CI = 1.03–6.30, p =.042). Poor sleep was independently associated with lower epilepsy‐related QoL after adjusting for affective symptoms and seizure frequency (OR = 1.79, 95% CI = 1.20–2.68, p =.005). Significance: Sleep quality in PWE is significantly impaired and strongly associated with anxiety, depression, and sociodemographic variables in addition to epilepsy‐specific factors. Poor sleep independently correlates with diminished QoL, supporting the value of routine screening for affective symptoms and sleep disturbances in epilepsy care. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Epilepsia (Series 4) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=190718449
RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.1111/epi.18599
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 16
        StartPage: 4764
    Subjects:
      – SubjectFull: Sleep quality
        Type: general
      – SubjectFull: Epilepsy
        Type: general
      – SubjectFull: Mental depression
        Type: general
      – SubjectFull: Anxiety
        Type: general
      – SubjectFull: Affective disorders
        Type: general
      – SubjectFull: Quality of life
        Type: general
      – SubjectFull: Cross-sectional method
        Type: general
      – SubjectFull: Germany
        Type: general
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      – TitleFull: Sleep quality and its correlates in people with epilepsy: A multicenter cross‐sectional study in Germany.
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            – D: 01
              M: 12
              Text: Dec2025
              Type: published
              Y: 2025
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