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Is there really evidence for neurodegeneration in Dravet syndrome? Commentary on the publication by Selvarajah et al.

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Title: Is there really evidence for neurodegeneration in Dravet syndrome? Commentary on the publication by Selvarajah et al.
Authors: Sisodiya, Sanjay M. (AUTHOR), Balestrini, Simona (AUTHOR), Berkovic, Samuel F. (AUTHOR), Bhatia, Kailash P. (AUTHOR), Clayton, Lisa M. (AUTHOR), Cross, J. Helen (AUTHOR), Eldred, Claire (AUTHOR), Gambardella, Antonio (AUTHOR), Guerrini, Renzo (AUTHOR), Nabbout, Rima (AUTHOR), Strzelczyk, Adam (AUTHOR), Wilson, Galia (AUTHOR), Scheffer, Ingrid E. (AUTHOR)
Source: Epilepsia (Series 4). Oct2025, Vol. 66 Issue 10, p3676-3680. 5p.
Subjects: Neurodegeneration, Longitudinal method, Pathological physiology, Patients, Childhood epilepsy, Research integrity
Abstract: The article focuses on the ongoing debate regarding whether Dravet syndrome (DS) should be classified as a neurodegenerative disease. While there is evidence suggesting that DS is a slowly progressive condition, the authors argue that current data do not support the classification of DS as neurodegenerative due to a lack of evidence for neuronal loss and the potential influence of confounding factors. They emphasize the need for rigorous longitudinal studies to clarify the pathophysiology of DS and to distinguish between true neurodegeneration and other reversible factors affecting patients. The authors advocate for comprehensive evaluations and management of all morbidities associated with DS, highlighting the importance of methodological rigor in future research. [Extracted from the article]
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Database: Psychology and Behavioral Sciences Collection
Description
Abstract:The article focuses on the ongoing debate regarding whether Dravet syndrome (DS) should be classified as a neurodegenerative disease. While there is evidence suggesting that DS is a slowly progressive condition, the authors argue that current data do not support the classification of DS as neurodegenerative due to a lack of evidence for neuronal loss and the potential influence of confounding factors. They emphasize the need for rigorous longitudinal studies to clarify the pathophysiology of DS and to distinguish between true neurodegeneration and other reversible factors affecting patients. The authors advocate for comprehensive evaluations and management of all morbidities associated with DS, highlighting the importance of methodological rigor in future research. [Extracted from the article]
ISSN:00139580
DOI:10.1111/epi.18582