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Is there really evidence for neurodegeneration in Dravet syndrome? Commentary on the publication by Selvarajah et al.

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Title: Is there really evidence for neurodegeneration in Dravet syndrome? Commentary on the publication by Selvarajah et al.
Authors: Sisodiya, Sanjay M. (AUTHOR), Balestrini, Simona (AUTHOR), Berkovic, Samuel F. (AUTHOR), Bhatia, Kailash P. (AUTHOR), Clayton, Lisa M. (AUTHOR), Cross, J. Helen (AUTHOR), Eldred, Claire (AUTHOR), Gambardella, Antonio (AUTHOR), Guerrini, Renzo (AUTHOR), Nabbout, Rima (AUTHOR), Strzelczyk, Adam (AUTHOR), Wilson, Galia (AUTHOR), Scheffer, Ingrid E. (AUTHOR)
Source: Epilepsia (Series 4). Oct2025, Vol. 66 Issue 10, p3676-3680. 5p.
Subjects: Neurodegeneration, Longitudinal method, Pathological physiology, Patients, Childhood epilepsy, Research integrity
Abstract: The article focuses on the ongoing debate regarding whether Dravet syndrome (DS) should be classified as a neurodegenerative disease. While there is evidence suggesting that DS is a slowly progressive condition, the authors argue that current data do not support the classification of DS as neurodegenerative due to a lack of evidence for neuronal loss and the potential influence of confounding factors. They emphasize the need for rigorous longitudinal studies to clarify the pathophysiology of DS and to distinguish between true neurodegeneration and other reversible factors affecting patients. The authors advocate for comprehensive evaluations and management of all morbidities associated with DS, highlighting the importance of methodological rigor in future research. [Extracted from the article]
Copyright of Epilepsia (Series 4) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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DbLabel: Psychology and Behavioral Sciences Collection
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Is there really evidence for neurodegeneration in Dravet syndrome? Commentary on the publication by Selvarajah et al.
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  Data: <searchLink fieldCode="AR" term="%22Sisodiya%2C+Sanjay+M%2E%22">Sisodiya, Sanjay M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Balestrini%2C+Simona%22">Balestrini, Simona</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Berkovic%2C+Samuel+F%2E%22">Berkovic, Samuel F.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bhatia%2C+Kailash+P%2E%22">Bhatia, Kailash P.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Clayton%2C+Lisa+M%2E%22">Clayton, Lisa M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cross%2C+J%2E+Helen%22">Cross, J. Helen</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Eldred%2C+Claire%22">Eldred, Claire</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gambardella%2C+Antonio%22">Gambardella, Antonio</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Guerrini%2C+Renzo%22">Guerrini, Renzo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nabbout%2C+Rima%22">Nabbout, Rima</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Strzelczyk%2C+Adam%22">Strzelczyk, Adam</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wilson%2C+Galia%22">Wilson, Galia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Scheffer%2C+Ingrid+E%2E%22">Scheffer, Ingrid E.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Epilepsia+%28Series+4%29%22">Epilepsia (Series 4)</searchLink>. Oct2025, Vol. 66 Issue 10, p3676-3680. 5p.
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  Data: <searchLink fieldCode="DE" term="%22Neurodegeneration%22">Neurodegeneration</searchLink><br /><searchLink fieldCode="DE" term="%22Longitudinal+method%22">Longitudinal method</searchLink><br /><searchLink fieldCode="DE" term="%22Pathological+physiology%22">Pathological physiology</searchLink><br /><searchLink fieldCode="DE" term="%22Patients%22">Patients</searchLink><br /><searchLink fieldCode="DE" term="%22Childhood+epilepsy%22">Childhood epilepsy</searchLink><br /><searchLink fieldCode="DE" term="%22Research+integrity%22">Research integrity</searchLink>
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  Data: The article focuses on the ongoing debate regarding whether Dravet syndrome (DS) should be classified as a neurodegenerative disease. While there is evidence suggesting that DS is a slowly progressive condition, the authors argue that current data do not support the classification of DS as neurodegenerative due to a lack of evidence for neuronal loss and the potential influence of confounding factors. They emphasize the need for rigorous longitudinal studies to clarify the pathophysiology of DS and to distinguish between true neurodegeneration and other reversible factors affecting patients. The authors advocate for comprehensive evaluations and management of all morbidities associated with DS, highlighting the importance of methodological rigor in future research. [Extracted from the article]
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  Data: <i>Copyright of Epilepsia (Series 4) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=190860359
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      – SubjectFull: Pathological physiology
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              Text: Oct2025
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