View in EDS

Association of prenatal antidepressant use with internalizing behaviors from kindergarten to adolescence.

Saved in:
Bibliographic Details
Title: Association of prenatal antidepressant use with internalizing behaviors from kindergarten to adolescence.
Authors: Nitschke, Amanda S. (AUTHOR), Kaur, Paramdeep (AUTHOR), Phagau, Naomi (AUTHOR), do Valle, Helena Abreu (AUTHOR), Bone, Jeffrey N. (AUTHOR), Poon, Brenda (AUTHOR), Guhn, Martin (AUTHOR), Vigod, Simone N. (AUTHOR), Oberlander, Tim F. (AUTHOR), Hanley, Gillian E. (AUTHOR)
Source: Journal of Child Psychology & Psychiatry. Mar2026, Vol. 67 Issue 3, p355-365. 11p.
Subjects: Risk assessment, Prenatal exposure delayed effects, Research funding, Population-based case control, Mental health, Psychology of school children, Psychology of high school students, Serotonin uptake inhibitors, Questionnaires, Logistic regression analysis, Internalizing behavior, Retrospective studies, Descriptive statistics, Multivariate analysis, Antidepressants, Prenatal care, Longitudinal method, Odds ratio, Neurotransmitter uptake inhibitors, Anxiety disorders, Confidence intervals, Mental depression, Child behavior, Evaluation
Geographic Terms: Canada
Abstract: Background: To examine, using repeated measures, whether prenatal serotonin/norepinephrine reuptake inhibitor (SRI) antidepressant exposure is associated with increased anxious behaviors at kindergarten age and anxiety and/or depression behaviors after kindergarten and into adolescence. Methods: This population‐based retrospective cohort study included all live singleton infants delivered in British Columbia, Canada between January 2001 and December 2012 with complete outcome data. Follow‐up lasted until December 2022. Logistic regression models were used to estimate unadjusted and adjusted odds ratios (OR). To minimize confounding, high‐dimensional propensity score adjustment and a matched discordant sibling‐pair analysis were conducted. Results: Prenatal SRI exposure was associated with increased anxious behaviors in kindergarten (OR 1.77 [95% CI 1.59–1.97]) and anxiety and/or depression diagnostic codes in later childhood or adolescence (OR 2.09 [95% CI 1.97–2.22]). These associations attenuated but remained positive after high‐dimensional propensity score adjustment; however, the associations did not remain in the conditional logistic regression of discordant sibling pairs (aORs 0.92 [95% CI 0.61–1.37] and 1.02 [95% CI 0.79–1.33]). Regardless of SRI exposure, children with high levels of anxious behaviors at kindergarten were more likely to receive anxiety and/or depression diagnostic codes later on (SRI exposed: aOR 1.59 [95% CI 1.24–2.06]; SRI unexposed: aOR 1.64 [95% CI 1.51–1.77]). Conclusions: The associations of prenatal SRI exposure with increased internalizing behaviors at kindergarten and into adolescence are likely due to shared genetics or environmental factors. Findings also suggested kindergarten as a time for targeted interventions to address developmental vulnerabilities and prevent later development of anxiety and/or depression. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Child Psychology & Psychiatry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 191429002
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Association of prenatal antidepressant use with internalizing behaviors from kindergarten to adolescence.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Nitschke%2C+Amanda+S%2E%22">Nitschke, Amanda S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kaur%2C+Paramdeep%22">Kaur, Paramdeep</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Phagau%2C+Naomi%22">Phagau, Naomi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22do+Valle%2C+Helena+Abreu%22">do Valle, Helena Abreu</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bone%2C+Jeffrey+N%2E%22">Bone, Jeffrey N.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Poon%2C+Brenda%22">Poon, Brenda</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Guhn%2C+Martin%22">Guhn, Martin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vigod%2C+Simone+N%2E%22">Vigod, Simone N.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Oberlander%2C+Tim+F%2E%22">Oberlander, Tim F.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hanley%2C+Gillian+E%2E%22">Hanley, Gillian E.</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Journal+of+Child+Psychology+%26+Psychiatry%22">Journal of Child Psychology & Psychiatry</searchLink>. Mar2026, Vol. 67 Issue 3, p355-365. 11p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Risk+assessment%22">Risk assessment</searchLink><br /><searchLink fieldCode="DE" term="%22Prenatal+exposure+delayed+effects%22">Prenatal exposure delayed effects</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Population-based+case+control%22">Population-based case control</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+health%22">Mental health</searchLink><br /><searchLink fieldCode="DE" term="%22Psychology+of+school+children%22">Psychology of school children</searchLink><br /><searchLink fieldCode="DE" term="%22Psychology+of+high+school+students%22">Psychology of high school students</searchLink><br /><searchLink fieldCode="DE" term="%22Serotonin+uptake+inhibitors%22">Serotonin uptake inhibitors</searchLink><br /><searchLink fieldCode="DE" term="%22Questionnaires%22">Questionnaires</searchLink><br /><searchLink fieldCode="DE" term="%22Logistic+regression+analysis%22">Logistic regression analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Internalizing+behavior%22">Internalizing behavior</searchLink><br /><searchLink fieldCode="DE" term="%22Retrospective+studies%22">Retrospective studies</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Multivariate+analysis%22">Multivariate analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Antidepressants%22">Antidepressants</searchLink><br /><searchLink fieldCode="DE" term="%22Prenatal+care%22">Prenatal care</searchLink><br /><searchLink fieldCode="DE" term="%22Longitudinal+method%22">Longitudinal method</searchLink><br /><searchLink fieldCode="DE" term="%22Odds+ratio%22">Odds ratio</searchLink><br /><searchLink fieldCode="DE" term="%22Neurotransmitter+uptake+inhibitors%22">Neurotransmitter uptake inhibitors</searchLink><br /><searchLink fieldCode="DE" term="%22Anxiety+disorders%22">Anxiety disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Confidence+intervals%22">Confidence intervals</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Child+behavior%22">Child behavior</searchLink><br /><searchLink fieldCode="DE" term="%22Evaluation%22">Evaluation</searchLink>
– Name: SubjectGeographic
  Label: Geographic Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Canada%22">Canada</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: To examine, using repeated measures, whether prenatal serotonin/norepinephrine reuptake inhibitor (SRI) antidepressant exposure is associated with increased anxious behaviors at kindergarten age and anxiety and/or depression behaviors after kindergarten and into adolescence. Methods: This population‐based retrospective cohort study included all live singleton infants delivered in British Columbia, Canada between January 2001 and December 2012 with complete outcome data. Follow‐up lasted until December 2022. Logistic regression models were used to estimate unadjusted and adjusted odds ratios (OR). To minimize confounding, high‐dimensional propensity score adjustment and a matched discordant sibling‐pair analysis were conducted. Results: Prenatal SRI exposure was associated with increased anxious behaviors in kindergarten (OR 1.77 [95% CI 1.59–1.97]) and anxiety and/or depression diagnostic codes in later childhood or adolescence (OR 2.09 [95% CI 1.97–2.22]). These associations attenuated but remained positive after high‐dimensional propensity score adjustment; however, the associations did not remain in the conditional logistic regression of discordant sibling pairs (aORs 0.92 [95% CI 0.61–1.37] and 1.02 [95% CI 0.79–1.33]). Regardless of SRI exposure, children with high levels of anxious behaviors at kindergarten were more likely to receive anxiety and/or depression diagnostic codes later on (SRI exposed: aOR 1.59 [95% CI 1.24–2.06]; SRI unexposed: aOR 1.64 [95% CI 1.51–1.77]). Conclusions: The associations of prenatal SRI exposure with increased internalizing behaviors at kindergarten and into adolescence are likely due to shared genetics or environmental factors. Findings also suggested kindergarten as a time for targeted interventions to address developmental vulnerabilities and prevent later development of anxiety and/or depression. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Child Psychology & Psychiatry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=191429002
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/jcpp.70056
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 11
        StartPage: 355
    Subjects:
      – SubjectFull: Risk assessment
        Type: general
      – SubjectFull: Prenatal exposure delayed effects
        Type: general
      – SubjectFull: Research funding
        Type: general
      – SubjectFull: Population-based case control
        Type: general
      – SubjectFull: Mental health
        Type: general
      – SubjectFull: Psychology of school children
        Type: general
      – SubjectFull: Psychology of high school students
        Type: general
      – SubjectFull: Serotonin uptake inhibitors
        Type: general
      – SubjectFull: Questionnaires
        Type: general
      – SubjectFull: Logistic regression analysis
        Type: general
      – SubjectFull: Internalizing behavior
        Type: general
      – SubjectFull: Retrospective studies
        Type: general
      – SubjectFull: Descriptive statistics
        Type: general
      – SubjectFull: Multivariate analysis
        Type: general
      – SubjectFull: Antidepressants
        Type: general
      – SubjectFull: Prenatal care
        Type: general
      – SubjectFull: Longitudinal method
        Type: general
      – SubjectFull: Odds ratio
        Type: general
      – SubjectFull: Neurotransmitter uptake inhibitors
        Type: general
      – SubjectFull: Anxiety disorders
        Type: general
      – SubjectFull: Confidence intervals
        Type: general
      – SubjectFull: Mental depression
        Type: general
      – SubjectFull: Child behavior
        Type: general
      – SubjectFull: Evaluation
        Type: general
      – SubjectFull: Canada
        Type: general
    Titles:
      – TitleFull: Association of prenatal antidepressant use with internalizing behaviors from kindergarten to adolescence.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Nitschke, Amanda S.
      – PersonEntity:
          Name:
            NameFull: Kaur, Paramdeep
      – PersonEntity:
          Name:
            NameFull: Phagau, Naomi
      – PersonEntity:
          Name:
            NameFull: do Valle, Helena Abreu
      – PersonEntity:
          Name:
            NameFull: Bone, Jeffrey N.
      – PersonEntity:
          Name:
            NameFull: Poon, Brenda
      – PersonEntity:
          Name:
            NameFull: Guhn, Martin
      – PersonEntity:
          Name:
            NameFull: Vigod, Simone N.
      – PersonEntity:
          Name:
            NameFull: Oberlander, Tim F.
      – PersonEntity:
          Name:
            NameFull: Hanley, Gillian E.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 03
              Text: Mar2026
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-print
              Value: 00219630
          Numbering:
            – Type: volume
              Value: 67
            – Type: issue
              Value: 3
          Titles:
            – TitleFull: Journal of Child Psychology & Psychiatry
              Type: main
ResultId 1