View in EDS HTML Full Text PDF Full Text

Trajectories of lipid profile with cognitive function: 12-year follow-up of Guangzhou Biobank cohort study.

Saved in:
Bibliographic Details
Title: Trajectories of lipid profile with cognitive function: 12-year follow-up of Guangzhou Biobank cohort study.
Authors: Tian, Yu Meng (AUTHOR), Zhang, Wei Sen (AUTHOR), Jiang, Chao Qiang (AUTHOR), Zhu, Feng (AUTHOR), Jin, Ya Li (AUTHOR), Yeung, Shiu Lun Au (AUTHOR), Wang, Jiao (AUTHOR), Cheng, Kar Keung (AUTHOR), Lam, Tai Hing (AUTHOR), Xu, Lin (AUTHOR)
Source: European Archives of Psychiatry & Clinical Neuroscience. Feb2026, Vol. 276 Issue 1, p291-303. 13p.
Subjects: HDL cholesterol, LDL cholesterol, Triglycerides, Recollection (Psychology), Blood lipids, Cognitive ability, Cognition disorders, Cholesterol
Geographic Terms: Guangzhou (China)
Abstract: Studies on the trajectories of lipid profile with cognitive decline are scarce and inconsistent. We examined this association and explored potential effect modification. Lipid profiles including high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG) and total cholesterol (TC) were measured at baseline, first and second follow-ups, and classified into trajectory groups. Immediate, delayed memory recall and cognitive function were assessed by the immediate (IWRT) and delayed 10-word recall test (DWRT), and mini-mental state examination (MMSE), respectively, at baseline and follow-ups, and converted into standardized scores. Linear mixed-effect model was used. Results show that elevated HDL-C was associated with increasing annual change rates in DWRT and MMSE scores (β (95% confidence intervals) = 0.005 (-0.001 to 0.011) SD/year and 0.020 (0.014 to 0.027) SD/year, respectively), while LDL-C and TC were associated with a decrease in DWRT scores (-0.005 (-0.008 to -0.001) SD/year and − 0.009 (-0.011 to -0.006) SD/year, respectively). Moderate-increasing HDL-C, high-decreasing LDL-C or moderate-decreasing TC trajectories were associated with increases in DWRT, IWRT and MMSE scores. Stronger associations were identified for HDL-C with an increase in MMSE scores within the lower family income group and for LDL-C with a decrease in IWRT scores among individuals taking lipid-lowering drug. In conclusion, HDL-C was associated with improvements, while LDL-C and TC with decline in memory and cognitive function. Increasing HDL-C and decreasing LDL-C and TC trajectories predicted better memory and cognitive performance. The observed effect modifications highlight the importance of personalized approaches in lipid management to optimize cognitive outcomes. [ABSTRACT FROM AUTHOR]
Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 191574265
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Trajectories of lipid profile with cognitive function: 12-year follow-up of Guangzhou Biobank cohort study.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Tian%2C+Yu+Meng%22">Tian, Yu Meng</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Wei+Sen%22">Zhang, Wei Sen</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jiang%2C+Chao+Qiang%22">Jiang, Chao Qiang</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhu%2C+Feng%22">Zhu, Feng</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jin%2C+Ya+Li%22">Jin, Ya Li</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yeung%2C+Shiu+Lun+Au%22">Yeung, Shiu Lun Au</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Jiao%22">Wang, Jiao</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cheng%2C+Kar+Keung%22">Cheng, Kar Keung</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lam%2C+Tai+Hing%22">Lam, Tai Hing</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xu%2C+Lin%22">Xu, Lin</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22European+Archives+of+Psychiatry+%26+Clinical+Neuroscience%22">European Archives of Psychiatry & Clinical Neuroscience</searchLink>. Feb2026, Vol. 276 Issue 1, p291-303. 13p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22HDL+cholesterol%22">HDL cholesterol</searchLink><br /><searchLink fieldCode="DE" term="%22LDL+cholesterol%22">LDL cholesterol</searchLink><br /><searchLink fieldCode="DE" term="%22Triglycerides%22">Triglycerides</searchLink><br /><searchLink fieldCode="DE" term="%22Recollection+%28Psychology%29%22">Recollection (Psychology)</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+lipids%22">Blood lipids</searchLink><br /><searchLink fieldCode="DE" term="%22Cognitive+ability%22">Cognitive ability</searchLink><br /><searchLink fieldCode="DE" term="%22Cognition+disorders%22">Cognition disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Cholesterol%22">Cholesterol</searchLink>
– Name: SubjectGeographic
  Label: Geographic Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Guangzhou+%28China%29%22">Guangzhou (China)</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Studies on the trajectories of lipid profile with cognitive decline are scarce and inconsistent. We examined this association and explored potential effect modification. Lipid profiles including high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG) and total cholesterol (TC) were measured at baseline, first and second follow-ups, and classified into trajectory groups. Immediate, delayed memory recall and cognitive function were assessed by the immediate (IWRT) and delayed 10-word recall test (DWRT), and mini-mental state examination (MMSE), respectively, at baseline and follow-ups, and converted into standardized scores. Linear mixed-effect model was used. Results show that elevated HDL-C was associated with increasing annual change rates in DWRT and MMSE scores (β (95% confidence intervals) = 0.005 (-0.001 to 0.011) SD/year and 0.020 (0.014 to 0.027) SD/year, respectively), while LDL-C and TC were associated with a decrease in DWRT scores (-0.005 (-0.008 to -0.001) SD/year and − 0.009 (-0.011 to -0.006) SD/year, respectively). Moderate-increasing HDL-C, high-decreasing LDL-C or moderate-decreasing TC trajectories were associated with increases in DWRT, IWRT and MMSE scores. Stronger associations were identified for HDL-C with an increase in MMSE scores within the lower family income group and for LDL-C with a decrease in IWRT scores among individuals taking lipid-lowering drug. In conclusion, HDL-C was associated with improvements, while LDL-C and TC with decline in memory and cognitive function. Increasing HDL-C and decreasing LDL-C and TC trajectories predicted better memory and cognitive performance. The observed effect modifications highlight the importance of personalized approaches in lipid management to optimize cognitive outcomes. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=191574265
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s00406-025-01974-5
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 13
        StartPage: 291
    Subjects:
      – SubjectFull: HDL cholesterol
        Type: general
      – SubjectFull: LDL cholesterol
        Type: general
      – SubjectFull: Triglycerides
        Type: general
      – SubjectFull: Recollection (Psychology)
        Type: general
      – SubjectFull: Blood lipids
        Type: general
      – SubjectFull: Cognitive ability
        Type: general
      – SubjectFull: Cognition disorders
        Type: general
      – SubjectFull: Cholesterol
        Type: general
      – SubjectFull: Guangzhou (China)
        Type: general
    Titles:
      – TitleFull: Trajectories of lipid profile with cognitive function: 12-year follow-up of Guangzhou Biobank cohort study.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Tian, Yu Meng
      – PersonEntity:
          Name:
            NameFull: Zhang, Wei Sen
      – PersonEntity:
          Name:
            NameFull: Jiang, Chao Qiang
      – PersonEntity:
          Name:
            NameFull: Zhu, Feng
      – PersonEntity:
          Name:
            NameFull: Jin, Ya Li
      – PersonEntity:
          Name:
            NameFull: Yeung, Shiu Lun Au
      – PersonEntity:
          Name:
            NameFull: Wang, Jiao
      – PersonEntity:
          Name:
            NameFull: Cheng, Kar Keung
      – PersonEntity:
          Name:
            NameFull: Lam, Tai Hing
      – PersonEntity:
          Name:
            NameFull: Xu, Lin
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 02
              Text: Feb2026
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-print
              Value: 09401334
          Numbering:
            – Type: volume
              Value: 276
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: European Archives of Psychiatry & Clinical Neuroscience
              Type: main
ResultId 1