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Real world using dual biological therapy in severe asthma: Insights from four cases.

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Title: Real world using dual biological therapy in severe asthma: Insights from four cases.
Authors: Salameh, Laila (AUTHOR), Elhassan, Mona (AUTHOR), Mahboub, Bassam (AUTHOR)
Source: Journal of Asthma. Mar2026, Vol. 63 Issue 3, p389-393. 5p.
Subjects: Biotherapy, Asthma, Pulmonary function tests, Treatment effectiveness, Lung physiology, Disease exacerbation, Scientific observation, Corticosteroids
Abstract: Objective: To describe the clinical outcomes of patients with severe uncontrolled asthma who received dual biologic therapy after showing only partial improvement with a single biologic agent. Methods: We conducted a descriptive case series of four patients with severe asthma who remained inadequately controlled on biologic monotherapy. A second biologic targeting a different inflammatory pathway was added based on persistent symptoms and biomarker profiles. Clinical outcomes including Asthma Control Test (ACT) scores, asthma exacerbation frequency, oral corticosteroid (OCS) use, and lung function (FEV₁) were evaluated over 12 months of follow-up. Results: Following dual biologic therapy, all the patients showed significant improvement in Asthma Control Test (ACT) scores, reduction in exacerbations (from a median of 9 to 0.5/year), and reduced oral corticosteroid (OCS) usage (median 9 to 0.5/year). FEV1 remained stable or improved. No significant adverse effects were noted during 12 months of follow-up. Conclusion: This series highlights that dual biologic therapy is effective and safe in a carefully selected difficult subgroup of severe uncontrolled asthma. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Asthma is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Real world using dual biological therapy in severe asthma: Insights from four cases.
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  Data: <searchLink fieldCode="AR" term="%22Salameh%2C+Laila%22">Salameh, Laila</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Elhassan%2C+Mona%22">Elhassan, Mona</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mahboub%2C+Bassam%22">Mahboub, Bassam</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Asthma%22">Journal of Asthma</searchLink>. Mar2026, Vol. 63 Issue 3, p389-393. 5p.
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  Data: <searchLink fieldCode="DE" term="%22Biotherapy%22">Biotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Asthma%22">Asthma</searchLink><br /><searchLink fieldCode="DE" term="%22Pulmonary+function+tests%22">Pulmonary function tests</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Lung+physiology%22">Lung physiology</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+exacerbation%22">Disease exacerbation</searchLink><br /><searchLink fieldCode="DE" term="%22Scientific+observation%22">Scientific observation</searchLink><br /><searchLink fieldCode="DE" term="%22Corticosteroids%22">Corticosteroids</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective: To describe the clinical outcomes of patients with severe uncontrolled asthma who received dual biologic therapy after showing only partial improvement with a single biologic agent. Methods: We conducted a descriptive case series of four patients with severe asthma who remained inadequately controlled on biologic monotherapy. A second biologic targeting a different inflammatory pathway was added based on persistent symptoms and biomarker profiles. Clinical outcomes including Asthma Control Test (ACT) scores, asthma exacerbation frequency, oral corticosteroid (OCS) use, and lung function (FEV₁) were evaluated over 12 months of follow-up. Results: Following dual biologic therapy, all the patients showed significant improvement in Asthma Control Test (ACT) scores, reduction in exacerbations (from a median of 9 to 0.5/year), and reduced oral corticosteroid (OCS) usage (median 9 to 0.5/year). FEV1 remained stable or improved. No significant adverse effects were noted during 12 months of follow-up. Conclusion: This series highlights that dual biologic therapy is effective and safe in a carefully selected difficult subgroup of severe uncontrolled asthma. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Asthma is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/02770903.2025.2592236
    Languages:
      – Code: eng
        Text: English
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        PageCount: 5
        StartPage: 389
    Subjects:
      – SubjectFull: Biotherapy
        Type: general
      – SubjectFull: Asthma
        Type: general
      – SubjectFull: Pulmonary function tests
        Type: general
      – SubjectFull: Treatment effectiveness
        Type: general
      – SubjectFull: Lung physiology
        Type: general
      – SubjectFull: Disease exacerbation
        Type: general
      – SubjectFull: Scientific observation
        Type: general
      – SubjectFull: Corticosteroids
        Type: general
    Titles:
      – TitleFull: Real world using dual biological therapy in severe asthma: Insights from four cases.
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            NameFull: Salameh, Laila
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            NameFull: Elhassan, Mona
      – PersonEntity:
          Name:
            NameFull: Mahboub, Bassam
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            – D: 01
              M: 03
              Text: Mar2026
              Type: published
              Y: 2026
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              Value: 63
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            – TitleFull: Journal of Asthma
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