View in EDS HTML Full Text PDF Full Text

Patients Reported Adverse Effects of Antidepressants Among Depressive Disorder and Associated Risk Factors: A Multicenter Cross‐Sectional Study.

Saved in:
Bibliographic Details
Title: Patients Reported Adverse Effects of Antidepressants Among Depressive Disorder and Associated Risk Factors: A Multicenter Cross‐Sectional Study.
Authors: Chanie, Gashaw Sisay (AUTHOR), Geremew, Gebremariam Wulie (AUTHOR), Beyna, Alemante Tafese (AUTHOR), Fenta Misker, Melshew (AUTHOR), Ayele, Habtamu Semagne (AUTHOR), Teshager, Abebe Worku (AUTHOR), Takele, Girma Medfu (AUTHOR), Bizuneh, Gizachew Kassahun (AUTHOR), Azanaw, Jember (AUTHOR), Belachew, Eyayaw Ashete (AUTHOR), Simegn, Wudneh (AUTHOR), Su, Pu-Yu (AUTHOR)
Source: Depression & Anxiety (1091-4269). 2/23/2026, Vol. 2026, p1-11. 11p.
Subjects: Drug side effects, Disease risk factors, Mental depression, Cross-sectional method, Antidepressants, Ethiopians
Geographic Terms: Ethiopia
Abstract: Background: Over the last two decades, antidepressant usage has seen a notable rise. Following the initiation of antidepressant medication, numerous patients experience adverse drug reactions. The main objective of this research was to determine the adverse effects of antidepressants, and identify the associated factors for outpatients who had been diagnosed with depression in three chosen clinics specializing in psychiatry in Ethiopia. Methods: A prospective multicenter cross‐sectional study was carried out from June 12, 2024, to November 13, 2024, involving a total of 422 participants. An antidepressant side effect checklist (ASEC) was employed to evaluate side effects, and unstructured questionnaires were reviewed through interviews conducted with patients and their caregivers. The data collected were analyzed using the Statistical Package for the Social Sciences (SPSS), version 26.0. A descriptive summary of the data was compiled through analysis, and the findings were reported in terms of frequencies and percentages. A multivariate logistic regression analysis was conducted to examine the association between the predictor variables and the outcome measure. Associations were evaluated using odds ratios (ORs) with their corresponding 95% confidence intervals (CIs). Results: Among patients with depressive disorders, the antidepressant adverse effects were observed in 82.9% of cases, with a 95% CI of 79.6–86.7. The most common adverse effects were weight gain (64%), nausea and vomiting (51%), dry mouth (49%), and headache (41%). Female was associated with a threefold increased risk of antidepressant drug adverse effects (AOR = 3.56, 95% CI: 2.73, 5.43). Additionally, being unemployed (AOR = 1.35, 95% CI: 1.30, 6.52), having a monthly income of 620 Ethiopian Birr (AOR = 4.53, 95% CI: 4.24, 9.58), limited physical activity (AOR = 4.52, 95% CI: 3.47, 11.87, and AOR = 3.03, 95% CI: 1.92, 4.32), consuming alcohol (AOR = 1.23, 95% CI: 1.20, 3.03), and using drugs for more than 2 years (AOR = 1.37, 95% CI: 1.25, 3.58) were significantly linked to antidepressant drug adverse effects in patients with depressive disorders. Conclusion: Depressive disorder treatment often encounters side effects from antidepressants. Women who are unemployed, have a monthly income of less than 620 Ethiopian Birr, engage in a limited level of physical activity, consume alcohol, and have used drugs for more than 2 years experienced significant adverse effects from antidepressants. [ABSTRACT FROM AUTHOR]
Copyright of Depression & Anxiety (1091-4269) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 191805215
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Patients Reported Adverse Effects of Antidepressants Among Depressive Disorder and Associated Risk Factors: A Multicenter Cross‐Sectional Study.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Chanie%2C+Gashaw+Sisay%22">Chanie, Gashaw Sisay</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Geremew%2C+Gebremariam+Wulie%22">Geremew, Gebremariam Wulie</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Beyna%2C+Alemante+Tafese%22">Beyna, Alemante Tafese</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fenta+Misker%2C+Melshew%22">Fenta Misker, Melshew</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ayele%2C+Habtamu+Semagne%22">Ayele, Habtamu Semagne</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Teshager%2C+Abebe+Worku%22">Teshager, Abebe Worku</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Takele%2C+Girma+Medfu%22">Takele, Girma Medfu</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bizuneh%2C+Gizachew+Kassahun%22">Bizuneh, Gizachew Kassahun</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Azanaw%2C+Jember%22">Azanaw, Jember</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Belachew%2C+Eyayaw+Ashete%22">Belachew, Eyayaw Ashete</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Simegn%2C+Wudneh%22">Simegn, Wudneh</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Su%2C+Pu-Yu%22">Su, Pu-Yu</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Depression+%26+Anxiety+%281091-4269%29%22">Depression & Anxiety (1091-4269)</searchLink>. 2/23/2026, Vol. 2026, p1-11. 11p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Drug+side+effects%22">Drug side effects</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+risk+factors%22">Disease risk factors</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Cross-sectional+method%22">Cross-sectional method</searchLink><br /><searchLink fieldCode="DE" term="%22Antidepressants%22">Antidepressants</searchLink><br /><searchLink fieldCode="DE" term="%22Ethiopians%22">Ethiopians</searchLink>
– Name: SubjectGeographic
  Label: Geographic Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Ethiopia%22">Ethiopia</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Over the last two decades, antidepressant usage has seen a notable rise. Following the initiation of antidepressant medication, numerous patients experience adverse drug reactions. The main objective of this research was to determine the adverse effects of antidepressants, and identify the associated factors for outpatients who had been diagnosed with depression in three chosen clinics specializing in psychiatry in Ethiopia. Methods: A prospective multicenter cross‐sectional study was carried out from June 12, 2024, to November 13, 2024, involving a total of 422 participants. An antidepressant side effect checklist (ASEC) was employed to evaluate side effects, and unstructured questionnaires were reviewed through interviews conducted with patients and their caregivers. The data collected were analyzed using the Statistical Package for the Social Sciences (SPSS), version 26.0. A descriptive summary of the data was compiled through analysis, and the findings were reported in terms of frequencies and percentages. A multivariate logistic regression analysis was conducted to examine the association between the predictor variables and the outcome measure. Associations were evaluated using odds ratios (ORs) with their corresponding 95% confidence intervals (CIs). Results: Among patients with depressive disorders, the antidepressant adverse effects were observed in 82.9% of cases, with a 95% CI of 79.6–86.7. The most common adverse effects were weight gain (64%), nausea and vomiting (51%), dry mouth (49%), and headache (41%). Female was associated with a threefold increased risk of antidepressant drug adverse effects (AOR = 3.56, 95% CI: 2.73, 5.43). Additionally, being unemployed (AOR = 1.35, 95% CI: 1.30, 6.52), having a monthly income of 620 Ethiopian Birr (AOR = 4.53, 95% CI: 4.24, 9.58), limited physical activity (AOR = 4.52, 95% CI: 3.47, 11.87, and AOR = 3.03, 95% CI: 1.92, 4.32), consuming alcohol (AOR = 1.23, 95% CI: 1.20, 3.03), and using drugs for more than 2 years (AOR = 1.37, 95% CI: 1.25, 3.58) were significantly linked to antidepressant drug adverse effects in patients with depressive disorders. Conclusion: Depressive disorder treatment often encounters side effects from antidepressants. Women who are unemployed, have a monthly income of less than 620 Ethiopian Birr, engage in a limited level of physical activity, consume alcohol, and have used drugs for more than 2 years experienced significant adverse effects from antidepressants. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Depression & Anxiety (1091-4269) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=191805215
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1155/da/9957695
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 11
        StartPage: 1
    Subjects:
      – SubjectFull: Drug side effects
        Type: general
      – SubjectFull: Disease risk factors
        Type: general
      – SubjectFull: Mental depression
        Type: general
      – SubjectFull: Cross-sectional method
        Type: general
      – SubjectFull: Antidepressants
        Type: general
      – SubjectFull: Ethiopians
        Type: general
      – SubjectFull: Ethiopia
        Type: general
    Titles:
      – TitleFull: Patients Reported Adverse Effects of Antidepressants Among Depressive Disorder and Associated Risk Factors: A Multicenter Cross‐Sectional Study.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Chanie, Gashaw Sisay
      – PersonEntity:
          Name:
            NameFull: Geremew, Gebremariam Wulie
      – PersonEntity:
          Name:
            NameFull: Beyna, Alemante Tafese
      – PersonEntity:
          Name:
            NameFull: Fenta Misker, Melshew
      – PersonEntity:
          Name:
            NameFull: Ayele, Habtamu Semagne
      – PersonEntity:
          Name:
            NameFull: Teshager, Abebe Worku
      – PersonEntity:
          Name:
            NameFull: Takele, Girma Medfu
      – PersonEntity:
          Name:
            NameFull: Bizuneh, Gizachew Kassahun
      – PersonEntity:
          Name:
            NameFull: Azanaw, Jember
      – PersonEntity:
          Name:
            NameFull: Belachew, Eyayaw Ashete
      – PersonEntity:
          Name:
            NameFull: Simegn, Wudneh
      – PersonEntity:
          Name:
            NameFull: Su, Pu-Yu
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 23
              M: 02
              Text: 2/23/2026
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-print
              Value: 10914269
          Numbering:
            – Type: volume
              Value: 2026
          Titles:
            – TitleFull: Depression & Anxiety (1091-4269)
              Type: main
ResultId 1