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Esketamine for depression: should the horizon be expanded to posttraumatic stress disorder?

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Title: Esketamine for depression: should the horizon be expanded to posttraumatic stress disorder?
Authors: Rothärmel, Maud (AUTHOR), Berkovitch, Lucie (AUTHOR), El-Hage, Wissam (AUTHOR), Bui, Eric (AUTHOR)
Source: International Journal of Mental Health. 2026, Vol. 55 Issue 1, p1-4. 4p.
Subjects: Prevention of mental depression, Post-traumatic stress disorder, Ketamine, Intranasal administration, Suicidal ideation, Patient safety, Neuroplasticity, Intravenous therapy, Experimental design, Learning strategies, Pathological psychology, Comorbidity
Abstract: This article focuses on the clinical use of ketamine and its enantiomer esketamine in treating treatment-resistant depression (TRD) and explores their potential application in posttraumatic stress disorder (PTSD). It highlights evidence that esketamine produces rapid antidepressant effects and may reduce certain PTSD symptoms, particularly when combined with trauma-focused psychotherapies such as Prolonged Exposure and Eye Movement Desensitization and Reprocessing (EMDR). The article emphasizes the complexity of treating patients with comorbid depression and PTSD, noting challenges related to safety, ethical considerations, and the need for integrated, multimodal treatment approaches. It calls for further rigorous research to expand esketamine’s clinical indications beyond depression while ensuring careful patient selection and monitoring. [Extracted from the article]
Copyright of International Journal of Mental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 191985097
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PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Esketamine for depression: should the horizon be expanded to posttraumatic stress disorder?
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Rothärmel%2C+Maud%22">Rothärmel, Maud</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Berkovitch%2C+Lucie%22">Berkovitch, Lucie</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22El-Hage%2C+Wissam%22">El-Hage, Wissam</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bui%2C+Eric%22">Bui, Eric</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Mental+Health%22">International Journal of Mental Health</searchLink>. 2026, Vol. 55 Issue 1, p1-4. 4p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Prevention+of+mental+depression%22">Prevention of mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Post-traumatic+stress+disorder%22">Post-traumatic stress disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Ketamine%22">Ketamine</searchLink><br /><searchLink fieldCode="DE" term="%22Intranasal+administration%22">Intranasal administration</searchLink><br /><searchLink fieldCode="DE" term="%22Suicidal+ideation%22">Suicidal ideation</searchLink><br /><searchLink fieldCode="DE" term="%22Patient+safety%22">Patient safety</searchLink><br /><searchLink fieldCode="DE" term="%22Neuroplasticity%22">Neuroplasticity</searchLink><br /><searchLink fieldCode="DE" term="%22Intravenous+therapy%22">Intravenous therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Experimental+design%22">Experimental design</searchLink><br /><searchLink fieldCode="DE" term="%22Learning+strategies%22">Learning strategies</searchLink><br /><searchLink fieldCode="DE" term="%22Pathological+psychology%22">Pathological psychology</searchLink><br /><searchLink fieldCode="DE" term="%22Comorbidity%22">Comorbidity</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: This article focuses on the clinical use of ketamine and its enantiomer esketamine in treating treatment-resistant depression (TRD) and explores their potential application in posttraumatic stress disorder (PTSD). It highlights evidence that esketamine produces rapid antidepressant effects and may reduce certain PTSD symptoms, particularly when combined with trauma-focused psychotherapies such as Prolonged Exposure and Eye Movement Desensitization and Reprocessing (EMDR). The article emphasizes the complexity of treating patients with comorbid depression and PTSD, noting challenges related to safety, ethical considerations, and the need for integrated, multimodal treatment approaches. It calls for further rigorous research to expand esketamine’s clinical indications beyond depression while ensuring careful patient selection and monitoring. [Extracted from the article]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of International Journal of Mental Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=191985097
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/00207411.2026.2625632
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 4
        StartPage: 1
    Subjects:
      – SubjectFull: Prevention of mental depression
        Type: general
      – SubjectFull: Post-traumatic stress disorder
        Type: general
      – SubjectFull: Ketamine
        Type: general
      – SubjectFull: Intranasal administration
        Type: general
      – SubjectFull: Suicidal ideation
        Type: general
      – SubjectFull: Patient safety
        Type: general
      – SubjectFull: Neuroplasticity
        Type: general
      – SubjectFull: Intravenous therapy
        Type: general
      – SubjectFull: Experimental design
        Type: general
      – SubjectFull: Learning strategies
        Type: general
      – SubjectFull: Pathological psychology
        Type: general
      – SubjectFull: Comorbidity
        Type: general
    Titles:
      – TitleFull: Esketamine for depression: should the horizon be expanded to posttraumatic stress disorder?
        Type: main
  BibRelationships:
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          Name:
            NameFull: Rothärmel, Maud
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            NameFull: Berkovitch, Lucie
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            NameFull: El-Hage, Wissam
      – PersonEntity:
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            NameFull: Bui, Eric
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            – D: 01
              M: 01
              Text: 2026
              Type: published
              Y: 2026
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              Value: 55
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            – TitleFull: International Journal of Mental Health
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