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Association between benign prostatic hyperplasia and depression and anxiety: a cross-sectional and prospective cohort study based on the UK biobank.

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Title: Association between benign prostatic hyperplasia and depression and anxiety: a cross-sectional and prospective cohort study based on the UK biobank.
Authors: Guo, Jinjing (AUTHOR), Zhou, Liang (AUTHOR), He, Jiaming (AUTHOR), Pan, Xinkai (AUTHOR), Liu, Dingwen (AUTHOR), Li, Jiaren (AUTHOR), Zhou, Qing (AUTHOR), Wang, Long (AUTHOR)
Source: International Journal of Psychiatry in Clinical Practice. Mar2026, Vol. 30 Issue 1, p30-39. 10p.
Subjects: Mental depression risk factors, Men, Risk assessment, Cross-sectional method, Research funding, Mental health, Income, Logistic regression analysis, Mendelian randomization, Questionnaires, Anxiety, Descriptive statistics, Age distribution, Benign prostatic hyperplasia, Uk Biobank Ltd., Longitudinal method, Odds ratio, Aging, Causality (Physics), Confidence intervals, Data analysis software, Employment, Physical activity, Proportional hazards models, Genetics, Sensitivity & specificity (Statistics), Disease risk factors, Disease complications
Abstract: Objectives: Benign prostatic hyperplasia (BPH) commonly affects ageing men, with unclear long-term psychiatric effects. We examined these associations using cross-sectional, longitudinal and genetic data from the UK Biobank. Methods: Our analysis of 229,001 UK Biobank individuals examined cross-sectional and prospective relationships between BPH and mental health. Logistic regression models investigated baseline associations, while 51,805 individuals followed for seven years and 171,228 following for 14.9 years assessed prospective hazards. To determine causality, Mendelian Randomisation (MR) was used. Results: At baseline, BPH is associated with higher odds of depression (OR: 1.42, 95% CI: 1.34–1.51) and anxiety (OR 1.44, 1.36–1.53). Prospectively, BPH predicted incident depression (OR 1.41, 1.12–1.79) and anxiety (OR 1.48, 1.09–2.01) at seven years and increased depression and anxiety risk over 14.9 years (HR 1.38, 1.24–1.53) and 1.45, 1.30–1.61). Subgroup analysis indicates that BPH significantly raises depression and anxiety risk, particularly in those aged <60, employed, high income or less active. BPH causes depression (OR 1.003, 1.000–1.006), but not anxiety, while bidirectional MR showed that anxiety slightly protects against BPH risk (OR 0.998, 0.997–1.000). Conclusion: BPH is associated with elevated risks of depression and anxiety, with genetic evidence supporting a causal link to depression. KEYPOINTS: Keypoints: Benign prostatic hyperplasia (BPH) is associated with increased long-term risks of depression and anxiety. Genetic evidence supports a causal relationship from BPH to depression, but not anxiety, highlighting differing mechanisms. Younger, employed, higher-income, and physically inactive men are especially vulnerable, suggesting targeted interventions are necessary. Future research should focus on developing interdisciplinary strategies for screening and supporting mental health in men with BPH [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Psychiatry in Clinical Practice is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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DbLabel: Psychology and Behavioral Sciences Collection
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PubType: Academic Journal
PubTypeId: academicJournal
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  Label: Title
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  Data: Association between benign prostatic hyperplasia and depression and anxiety: a cross-sectional and prospective cohort study based on the UK biobank.
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– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objectives: Benign prostatic hyperplasia (BPH) commonly affects ageing men, with unclear long-term psychiatric effects. We examined these associations using cross-sectional, longitudinal and genetic data from the UK Biobank. Methods: Our analysis of 229,001 UK Biobank individuals examined cross-sectional and prospective relationships between BPH and mental health. Logistic regression models investigated baseline associations, while 51,805 individuals followed for seven years and 171,228 following for 14.9 years assessed prospective hazards. To determine causality, Mendelian Randomisation (MR) was used. Results: At baseline, BPH is associated with higher odds of depression (OR: 1.42, 95% CI: 1.34–1.51) and anxiety (OR 1.44, 1.36–1.53). Prospectively, BPH predicted incident depression (OR 1.41, 1.12–1.79) and anxiety (OR 1.48, 1.09–2.01) at seven years and increased depression and anxiety risk over 14.9 years (HR 1.38, 1.24–1.53) and 1.45, 1.30–1.61). Subgroup analysis indicates that BPH significantly raises depression and anxiety risk, particularly in those aged &lt;60, employed, high income or less active. BPH causes depression (OR 1.003, 1.000–1.006), but not anxiety, while bidirectional MR showed that anxiety slightly protects against BPH risk (OR 0.998, 0.997–1.000). Conclusion: BPH is associated with elevated risks of depression and anxiety, with genetic evidence supporting a causal link to depression. KEYPOINTS: Keypoints: Benign prostatic hyperplasia (BPH) is associated with increased long-term risks of depression and anxiety. Genetic evidence supports a causal relationship from BPH to depression, but not anxiety, highlighting differing mechanisms. Younger, employed, higher-income, and physically inactive men are especially vulnerable, suggesting targeted interventions are necessary. Future research should focus on developing interdisciplinary strategies for screening and supporting mental health in men with BPH [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: &lt;i&gt;Copyright of International Journal of Psychiatry in Clinical Practice is the property of Taylor &amp; Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=191985223
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/13651501.2025.2579053
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 10
        StartPage: 30
    Subjects:
      – SubjectFull: Mental depression risk factors
        Type: general
      – SubjectFull: Men
        Type: general
      – SubjectFull: Risk assessment
        Type: general
      – SubjectFull: Cross-sectional method
        Type: general
      – SubjectFull: Research funding
        Type: general
      – SubjectFull: Mental health
        Type: general
      – SubjectFull: Income
        Type: general
      – SubjectFull: Logistic regression analysis
        Type: general
      – SubjectFull: Mendelian randomization
        Type: general
      – SubjectFull: Questionnaires
        Type: general
      – SubjectFull: Anxiety
        Type: general
      – SubjectFull: Descriptive statistics
        Type: general
      – SubjectFull: Age distribution
        Type: general
      – SubjectFull: Benign prostatic hyperplasia
        Type: general
      – SubjectFull: Uk Biobank Ltd.
        Type: general
      – SubjectFull: Longitudinal method
        Type: general
      – SubjectFull: Odds ratio
        Type: general
      – SubjectFull: Aging
        Type: general
      – SubjectFull: Causality (Physics)
        Type: general
      – SubjectFull: Confidence intervals
        Type: general
      – SubjectFull: Data analysis software
        Type: general
      – SubjectFull: Employment
        Type: general
      – SubjectFull: Physical activity
        Type: general
      – SubjectFull: Proportional hazards models
        Type: general
      – SubjectFull: Genetics
        Type: general
      – SubjectFull: Sensitivity & specificity (Statistics)
        Type: general
      – SubjectFull: Disease risk factors
        Type: general
      – SubjectFull: Disease complications
        Type: general
    Titles:
      – TitleFull: Association between benign prostatic hyperplasia and depression and anxiety: a cross-sectional and prospective cohort study based on the UK biobank.
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            – D: 01
              M: 03
              Text: Mar2026
              Type: published
              Y: 2026
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