Human Apolipoprotein B: Structure of Carboxyl-Terminal Domains, Sites of Gene Expression, and Chromosomal Localization.

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Bibliographic Details
Title:	Human Apolipoprotein B: Structure of Carboxyl-Terminal Domains, Sites of Gene Expression, and Chromosomal Localization.
Authors:	Knott, Timothy J. (AUTHOR), Rall, Jr., Stanley C. (AUTHOR), Innerarity, Thomas L. (AUTHOR), Jacobson, Shellie F. (AUTHOR), Urdea, Mickey S. (AUTHOR), Levy-Wilson, Beatriz (AUTHOR), Powell, Lyn M. (AUTHOR), Pease, Richard J. (AUTHOR), Eddy, Roger (AUTHOR), Nakai, Hiroshi (AUTHOR), Byers, Mary (AUTHOR), Priestley, Linda M. (AUTHOR), Robertson, Elaine (AUTHOR), Rail, Leslie B. (AUTHOR), Betsholtz, Christer (AUTHOR), Shows, Thomas B. (AUTHOR), Mahley, Robert W. (AUTHOR), Scott, James (AUTHOR)
Source:	Science (pre-March 2025). 10/4/1985, Vol. 230 Issue 4721, p37-43. 7p. 5 Diagrams, 1 Chart, 2 Graphs.
Abstract:	Apolipoprotein (apo-) B is the ligand responsible for the receptor-mediated catabolism of low density lipoproteins, the principal cholesterol-transporting lipoproteins in plasma. The primary structure of the carboxyl-terminal 30 percent (1455 amino acids) of human apo-B (apo-B100) has been deduced from the nucleotide sequence of complementary DNA. Portions of the protein structure that may relate to its receptor binding function and lipid binding properties have been identified. The apo-B1OO messenger RNA is about 19 kilobases in length. The apo-B1OO gene is expressed primarily in liver and, to a lesser extent, in small intestine, but in no other tissues. The gene for apo-B1O0 is located in the p24 region (near the tip of the short arm) of chromosome 2. [ABSTRACT FROM AUTHOR]
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Database:	Psychology and Behavioral Sciences Collection

Description
Abstract:	Apolipoprotein (apo-) B is the ligand responsible for the receptor-mediated catabolism of low density lipoproteins, the principal cholesterol-transporting lipoproteins in plasma. The primary structure of the carboxyl-terminal 30 percent (1455 amino acids) of human apo-B (apo-B100) has been deduced from the nucleotide sequence of complementary DNA. Portions of the protein structure that may relate to its receptor binding function and lipid binding properties have been identified. The apo-B1OO messenger RNA is about 19 kilobases in length. The apo-B1OO gene is expressed primarily in liver and, to a lesser extent, in small intestine, but in no other tissues. The gene for apo-B1O0 is located in the p24 region (near the tip of the short arm) of chromosome 2. [ABSTRACT FROM AUTHOR]
ISSN:	00368075
DOI:	10.1126/science.2994225