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Possible compensatory role of cerebellum in bipolar disorder. A cortical thickness study.

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Title: Possible compensatory role of cerebellum in bipolar disorder. A cortical thickness study.
Authors: Inuggi, Alberto (AUTHOR), Marenco, Giacomo (AUTHOR), Bode, Juxhin (AUTHOR), Bovio, Anna (AUTHOR), Versaggi, Silvio (AUTHOR), Favilla, Luca (AUTHOR), Pereira da Silva, Beatriz (AUTHOR), Picci, Rocco Luigi (AUTHOR), Amore, Mario (AUTHOR), Serafini, Gianluca (AUTHOR), Escelsior, Andrea (AUTHOR)
Source: European Archives of Psychiatry & Clinical Neuroscience. Mar2026, Vol. 276 Issue 2, p817-830. 14p.
Subjects: Bipolar disorder, Cerebellum, Brain anatomy, People with mental illness, Brain cortical thickness, Neuroplasticity
Abstract: Recent studies suggested that structural changes in the cerebellum are implicated in the pathophysiology of bipolar disorder (BD). Here, we aimed to characterize the structural alterations of cerebellar lobules in BD, evaluating their possible relation with those occurring in the rest of the brain. One-hundred-fifty-five type I BD patients were recruited and compared with one-hundred-nineteen controls subjects. Cerebral cortical thickness (CT) was evaluated vertex-wise, while cerebellar CT at the level of its twelve lobules. A widespread pattern of cortical thinning was found in several clusters of BD patients. In the cerebellum, we found an anterior thinning (lobule I_II, III, X) and a posterior thickening (crus I, crus II, lobule VI and lobule IX) of its lobules in BD. Exploring the relation between cerebral and cerebellar CT changes in BD patients, after correcting for age and disease duration, the CT of a large subset of cerebral regions, found thinned in BD, were also inversely correlated with the thickening of cerebellar lobule IX. We speculate that this lobule may undergo adaptive changes to compensate the widespread cortical thinning which characterizes BD syndrome. Such a compensatory adaptation of the cerebellum would be similar to that found in other neurological and psychiatric disorders. [ABSTRACT FROM AUTHOR]
Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Possible compensatory role of cerebellum in bipolar disorder. A cortical thickness study.
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  Data: <searchLink fieldCode="AR" term="%22Inuggi%2C+Alberto%22">Inuggi, Alberto</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Marenco%2C+Giacomo%22">Marenco, Giacomo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bode%2C+Juxhin%22">Bode, Juxhin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bovio%2C+Anna%22">Bovio, Anna</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Versaggi%2C+Silvio%22">Versaggi, Silvio</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Favilla%2C+Luca%22">Favilla, Luca</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pereira+da+Silva%2C+Beatriz%22">Pereira da Silva, Beatriz</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Picci%2C+Rocco+Luigi%22">Picci, Rocco Luigi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Amore%2C+Mario%22">Amore, Mario</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Serafini%2C+Gianluca%22">Serafini, Gianluca</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Escelsior%2C+Andrea%22">Escelsior, Andrea</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Archives+of+Psychiatry+%26+Clinical+Neuroscience%22">European Archives of Psychiatry & Clinical Neuroscience</searchLink>. Mar2026, Vol. 276 Issue 2, p817-830. 14p.
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  Data: <searchLink fieldCode="DE" term="%22Bipolar+disorder%22">Bipolar disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebellum%22">Cerebellum</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+anatomy%22">Brain anatomy</searchLink><br /><searchLink fieldCode="DE" term="%22People+with+mental+illness%22">People with mental illness</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+cortical+thickness%22">Brain cortical thickness</searchLink><br /><searchLink fieldCode="DE" term="%22Neuroplasticity%22">Neuroplasticity</searchLink>
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  Label: Abstract
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  Data: Recent studies suggested that structural changes in the cerebellum are implicated in the pathophysiology of bipolar disorder (BD). Here, we aimed to characterize the structural alterations of cerebellar lobules in BD, evaluating their possible relation with those occurring in the rest of the brain. One-hundred-fifty-five type I BD patients were recruited and compared with one-hundred-nineteen controls subjects. Cerebral cortical thickness (CT) was evaluated vertex-wise, while cerebellar CT at the level of its twelve lobules. A widespread pattern of cortical thinning was found in several clusters of BD patients. In the cerebellum, we found an anterior thinning (lobule I_II, III, X) and a posterior thickening (crus I, crus II, lobule VI and lobule IX) of its lobules in BD. Exploring the relation between cerebral and cerebellar CT changes in BD patients, after correcting for age and disease duration, the CT of a large subset of cerebral regions, found thinned in BD, were also inversely correlated with the thickening of cerebellar lobule IX. We speculate that this lobule may undergo adaptive changes to compensate the widespread cortical thinning which characterizes BD syndrome. Such a compensatory adaptation of the cerebellum would be similar to that found in other neurological and psychiatric disorders. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: Mar2026
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