Suboptimal antidepressant use among inpatients and outpatients with symptoms of depression: a cross-sectional analysis of the POKAL core data set.
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| Title: | Suboptimal antidepressant use among inpatients and outpatients with symptoms of depression: a cross-sectional analysis of the POKAL core data set. |
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| Authors: | Brisnik, V. (AUTHOR), Schechner, M. (AUTHOR), Landmesser, P. (AUTHOR), Schillok, H. (AUTHOR), Schoenweger, P. (AUTHOR), Rottenkolber, M. (AUTHOR), Lindemann, D. (AUTHOR), Lukaschek, K. (AUTHOR), Jung-Sievers, C. (AUTHOR), Falkai, P. (AUTHOR), Henningsen, P. (AUTHOR), Pitschel-Walz, G. (AUTHOR), Krcmar, H. (AUTHOR), Schneider, A. (AUTHOR), Haas, C. (AUTHOR), Gökce, F. (AUTHOR), Eder, J. (AUTHOR), Pfeiffer, L. (AUTHOR), von Schrottenberg, V. (AUTHOR), Teusen, C. (AUTHOR) |
| Source: | European Archives of Psychiatry & Clinical Neuroscience. Mar2026, Vol. 276 Issue 2, p683-689. 7p. |
| Subjects: | Antidepressants, Mental depression, Polypharmacy, Treatment effectiveness, Inpatient care, Outpatients, Serotonin uptake inhibitors |
| Abstract: | We present a cross-sectional analysis of 1391 outpatients and 280 inpatients participating in subprojects of the Research Training Group POKAL, of whom 1609 had a PHQ-9 score ≥ 5 and 62 reported depression with antidepressant use. Antidepressant use was lower among outpatients than inpatients (28.5% vs. 82.5%), with higher levels of SSRI monotherapy (44.1% vs. 25.5%). Of antidepressant users, 80.1% had potentially inadequate treatment response, 21.7% high-risk use and of those with severe symptoms, 42.1% were potentially undertreated. Key risk factors were higher anxiety levels (for inadequate treatment response) and polypharmacy (for high-risk use), while previous depressive episode was protective against potential undertreatment. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | We present a cross-sectional analysis of 1391 outpatients and 280 inpatients participating in subprojects of the Research Training Group POKAL, of whom 1609 had a PHQ-9 score ≥ 5 and 62 reported depression with antidepressant use. Antidepressant use was lower among outpatients than inpatients (28.5% vs. 82.5%), with higher levels of SSRI monotherapy (44.1% vs. 25.5%). Of antidepressant users, 80.1% had potentially inadequate treatment response, 21.7% high-risk use and of those with severe symptoms, 42.1% were potentially undertreated. Key risk factors were higher anxiety levels (for inadequate treatment response) and polypharmacy (for high-risk use), while previous depressive episode was protective against potential undertreatment. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 09401334 |
| DOI: | 10.1007/s00406-025-01989-y |
