The association between anhedonia and prefrontal cortex activation in patients with major depression: a functional near-infrared spectroscopy study.
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| Title: | The association between anhedonia and prefrontal cortex activation in patients with major depression: a functional near-infrared spectroscopy study. |
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| Authors: | Chen, Li-Fen (AUTHOR), Lin, Ching-En (AUTHOR), Chung, Chi-Hsiang (AUTHOR), Chung, Yong-An (AUTHOR), Park, Sonya Youngju (AUTHOR), Chang, Wei-Chou (AUTHOR), Chang, Chuan-Chia (AUTHOR), Chang, Hsin-An (AUTHOR) |
| Source: | European Archives of Psychiatry & Clinical Neuroscience. Mar2026, Vol. 276 Issue 2, p731-747. 17p. |
| Subjects: | Anhedonia, Prefrontal cortex, Mental depression, Near infrared spectroscopy, Antidepressants, Cerebral circulation, Graph theory |
| Abstract: | This study investigated cerebral blood flow characteristics using functional nearinfrared spectroscopy (fNIRS) in agomelatine-treated depressed patients with anhedonia. The level of anhedonia was assessed by the Snaith Hamilton Rating Scale (SHAPS) and Montgomery Åsberg Depression Rating Scale 5-item (MADRS 5-item) score. All 84 patients were evaluated on the day of the study initiation and followed at week 1, 4 and 8 after the study initiation. Graph theory-based network analysis showed 2-back task-modulated global efficiency (adjusted B = 0.055, 95% CI = 0.043 - 0.066) and local efficiency (adjusted B = 0.066, 95% CI = 0.050 - 0.081) were significantly increased 1 week after treatment compared with the baseline. Furthermore, the increased oxy-hemoglobin (oxy-Hb) values from the baseline to the one week after treatment was positively related to the total MADRAS 5-item score reductions in the left-hemispheric orbitofrontal cortex (r = - 0.307, p = 0.005). Our findings suggest that abnormal functional connectivity over OFC may reflect the pathophysiological characteristics of anhedonia and serve as a clinical biomarker for anhedonia. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | This study investigated cerebral blood flow characteristics using functional nearinfrared spectroscopy (fNIRS) in agomelatine-treated depressed patients with anhedonia. The level of anhedonia was assessed by the Snaith Hamilton Rating Scale (SHAPS) and Montgomery Åsberg Depression Rating Scale 5-item (MADRS 5-item) score. All 84 patients were evaluated on the day of the study initiation and followed at week 1, 4 and 8 after the study initiation. Graph theory-based network analysis showed 2-back task-modulated global efficiency (adjusted B = 0.055, 95% CI = 0.043 - 0.066) and local efficiency (adjusted B = 0.066, 95% CI = 0.050 - 0.081) were significantly increased 1 week after treatment compared with the baseline. Furthermore, the increased oxy-hemoglobin (oxy-Hb) values from the baseline to the one week after treatment was positively related to the total MADRAS 5-item score reductions in the left-hemispheric orbitofrontal cortex (r = - 0.307, p = 0.005). Our findings suggest that abnormal functional connectivity over OFC may reflect the pathophysiological characteristics of anhedonia and serve as a clinical biomarker for anhedonia. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 09401334 |
| DOI: | 10.1007/s00406-025-02010-2 |
