View in EDS HTML Full Text PDF Full Text

The association between anhedonia and prefrontal cortex activation in patients with major depression: a functional near-infrared spectroscopy study.

Saved in:
Bibliographic Details
Title: The association between anhedonia and prefrontal cortex activation in patients with major depression: a functional near-infrared spectroscopy study.
Authors: Chen, Li-Fen (AUTHOR), Lin, Ching-En (AUTHOR), Chung, Chi-Hsiang (AUTHOR), Chung, Yong-An (AUTHOR), Park, Sonya Youngju (AUTHOR), Chang, Wei-Chou (AUTHOR), Chang, Chuan-Chia (AUTHOR), Chang, Hsin-An (AUTHOR)
Source: European Archives of Psychiatry & Clinical Neuroscience. Mar2026, Vol. 276 Issue 2, p731-747. 17p.
Subjects: Anhedonia, Prefrontal cortex, Mental depression, Near infrared spectroscopy, Antidepressants, Cerebral circulation, Graph theory
Abstract: This study investigated cerebral blood flow characteristics using functional nearinfrared spectroscopy (fNIRS) in agomelatine-treated depressed patients with anhedonia. The level of anhedonia was assessed by the Snaith Hamilton Rating Scale (SHAPS) and Montgomery Åsberg Depression Rating Scale 5-item (MADRS 5-item) score. All 84 patients were evaluated on the day of the study initiation and followed at week 1, 4 and 8 after the study initiation. Graph theory-based network analysis showed 2-back task-modulated global efficiency (adjusted B = 0.055, 95% CI = 0.043 - 0.066) and local efficiency (adjusted B = 0.066, 95% CI = 0.050 - 0.081) were significantly increased 1 week after treatment compared with the baseline. Furthermore, the increased oxy-hemoglobin (oxy-Hb) values from the baseline to the one week after treatment was positively related to the total MADRAS 5-item score reductions in the left-hemispheric orbitofrontal cortex (r = - 0.307, p = 0.005). Our findings suggest that abnormal functional connectivity over OFC may reflect the pathophysiological characteristics of anhedonia and serve as a clinical biomarker for anhedonia. [ABSTRACT FROM AUTHOR]
Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 192008784
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: The association between anhedonia and prefrontal cortex activation in patients with major depression: a functional near-infrared spectroscopy study.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Chen%2C+Li-Fen%22">Chen, Li-Fen</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lin%2C+Ching-En%22">Lin, Ching-En</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chung%2C+Chi-Hsiang%22">Chung, Chi-Hsiang</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chung%2C+Yong-An%22">Chung, Yong-An</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Park%2C+Sonya+Youngju%22">Park, Sonya Youngju</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chang%2C+Wei-Chou%22">Chang, Wei-Chou</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chang%2C+Chuan-Chia%22">Chang, Chuan-Chia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chang%2C+Hsin-An%22">Chang, Hsin-An</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22European+Archives+of+Psychiatry+%26+Clinical+Neuroscience%22">European Archives of Psychiatry & Clinical Neuroscience</searchLink>. Mar2026, Vol. 276 Issue 2, p731-747. 17p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Anhedonia%22">Anhedonia</searchLink><br /><searchLink fieldCode="DE" term="%22Prefrontal+cortex%22">Prefrontal cortex</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Near+infrared+spectroscopy%22">Near infrared spectroscopy</searchLink><br /><searchLink fieldCode="DE" term="%22Antidepressants%22">Antidepressants</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebral+circulation%22">Cerebral circulation</searchLink><br /><searchLink fieldCode="DE" term="%22Graph+theory%22">Graph theory</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: This study investigated cerebral blood flow characteristics using functional nearinfrared spectroscopy (fNIRS) in agomelatine-treated depressed patients with anhedonia. The level of anhedonia was assessed by the Snaith Hamilton Rating Scale (SHAPS) and Montgomery Åsberg Depression Rating Scale 5-item (MADRS 5-item) score. All 84 patients were evaluated on the day of the study initiation and followed at week 1, 4 and 8 after the study initiation. Graph theory-based network analysis showed 2-back task-modulated global efficiency (adjusted B = 0.055, 95% CI = 0.043 - 0.066) and local efficiency (adjusted B = 0.066, 95% CI = 0.050 - 0.081) were significantly increased 1 week after treatment compared with the baseline. Furthermore, the increased oxy-hemoglobin (oxy-Hb) values from the baseline to the one week after treatment was positively related to the total MADRAS 5-item score reductions in the left-hemispheric orbitofrontal cortex (r = - 0.307, p = 0.005). Our findings suggest that abnormal functional connectivity over OFC may reflect the pathophysiological characteristics of anhedonia and serve as a clinical biomarker for anhedonia. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=192008784
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s00406-025-02010-2
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 17
        StartPage: 731
    Subjects:
      – SubjectFull: Anhedonia
        Type: general
      – SubjectFull: Prefrontal cortex
        Type: general
      – SubjectFull: Mental depression
        Type: general
      – SubjectFull: Near infrared spectroscopy
        Type: general
      – SubjectFull: Antidepressants
        Type: general
      – SubjectFull: Cerebral circulation
        Type: general
      – SubjectFull: Graph theory
        Type: general
    Titles:
      – TitleFull: The association between anhedonia and prefrontal cortex activation in patients with major depression: a functional near-infrared spectroscopy study.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Chen, Li-Fen
      – PersonEntity:
          Name:
            NameFull: Lin, Ching-En
      – PersonEntity:
          Name:
            NameFull: Chung, Chi-Hsiang
      – PersonEntity:
          Name:
            NameFull: Chung, Yong-An
      – PersonEntity:
          Name:
            NameFull: Park, Sonya Youngju
      – PersonEntity:
          Name:
            NameFull: Chang, Wei-Chou
      – PersonEntity:
          Name:
            NameFull: Chang, Chuan-Chia
      – PersonEntity:
          Name:
            NameFull: Chang, Hsin-An
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 03
              Text: Mar2026
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-print
              Value: 09401334
          Numbering:
            – Type: volume
              Value: 276
            – Type: issue
              Value: 2
          Titles:
            – TitleFull: European Archives of Psychiatry & Clinical Neuroscience
              Type: main
ResultId 1