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Secondary analysis of GenRED data (Genetics of Recurrent Early-Onset major Depression) using MERLIN.

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Title: Secondary analysis of GenRED data (Genetics of Recurrent Early-Onset major Depression) using MERLIN.
Authors: Amin, Mutaz (AUTHOR), Gragnoli, Claudia (AUTHOR)
Source: European Archives of Psychiatry & Clinical Neuroscience. Mar2026, Vol. 276 Issue 2, p723-729. 7p.
Subjects: Linkage (Genetics), Mental depression, Genetic markers, Gene mapping, Genetic databases, Population genetics, Heredity, Genetics
Abstract: The familial relevance of depression is a critical aspect, with evidence suggesting a substantial hereditary component. Investigating the inheritance patterns within families can provide valuable insights into the genetic underpinnings of depression. To gain a new perspective on the genetics underpinning of depression, we conducted a novel analysis of the Genetics of Recurrent Early-onset Depression (GenRED) dataset including 683 U.S. Caucasian families, each with one proband with recurrent early-onset major depression and at least one sibling with depression. Using the MERLIN tool, we identified 37 genomic markers with nominal significance linkage to early-onset recurrent depression. The findings differ from prior analyses of GenRED using a different analytical tool. Our findings highlight the variability and potential discrepancies that can arise from using different analytical tools on the same dataset. Given the chance of microsatellites undergoing duplication, mutations, and amplification errors, our two-point analysis can be more robust compared to the previous multipoint analysis. Also, one limitation is genetic admixture; studies with more homogenous ethnic groups are warranted. [ABSTRACT FROM AUTHOR]
Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Secondary analysis of GenRED data (Genetics of Recurrent Early-Onset major Depression) using MERLIN.
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  Data: <searchLink fieldCode="AR" term="%22Amin%2C+Mutaz%22">Amin, Mutaz</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gragnoli%2C+Claudia%22">Gragnoli, Claudia</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Archives+of+Psychiatry+%26+Clinical+Neuroscience%22">European Archives of Psychiatry & Clinical Neuroscience</searchLink>. Mar2026, Vol. 276 Issue 2, p723-729. 7p.
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  Data: <searchLink fieldCode="DE" term="%22Linkage+%28Genetics%29%22">Linkage (Genetics)</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+markers%22">Genetic markers</searchLink><br /><searchLink fieldCode="DE" term="%22Gene+mapping%22">Gene mapping</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+databases%22">Genetic databases</searchLink><br /><searchLink fieldCode="DE" term="%22Population+genetics%22">Population genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Heredity%22">Heredity</searchLink><br /><searchLink fieldCode="DE" term="%22Genetics%22">Genetics</searchLink>
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  Label: Abstract
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  Data: The familial relevance of depression is a critical aspect, with evidence suggesting a substantial hereditary component. Investigating the inheritance patterns within families can provide valuable insights into the genetic underpinnings of depression. To gain a new perspective on the genetics underpinning of depression, we conducted a novel analysis of the Genetics of Recurrent Early-onset Depression (GenRED) dataset including 683 U.S. Caucasian families, each with one proband with recurrent early-onset major depression and at least one sibling with depression. Using the MERLIN tool, we identified 37 genomic markers with nominal significance linkage to early-onset recurrent depression. The findings differ from prior analyses of GenRED using a different analytical tool. Our findings highlight the variability and potential discrepancies that can arise from using different analytical tools on the same dataset. Given the chance of microsatellites undergoing duplication, mutations, and amplification errors, our two-point analysis can be more robust compared to the previous multipoint analysis. Also, one limitation is genetic admixture; studies with more homogenous ethnic groups are warranted. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: Mar2026
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