View in EDS

Neuropsychological outcomes comparing traditional surgical approaches and laser interstitial thermal therapy for refractory mesial temporal lobe epilepsy: A systematic review and meta‐analysis.

Saved in:
Bibliographic Details
Title: Neuropsychological outcomes comparing traditional surgical approaches and laser interstitial thermal therapy for refractory mesial temporal lobe epilepsy: A systematic review and meta‐analysis.
Authors: Stavrogianni, Konstantina (AUTHOR), Poprelka, Katerina (AUTHOR), Fasilis, Theodoros (AUTHOR), Giannopapas, Vasileios (AUTHOR), Hahn, Wiebke (AUTHOR), Gorny, Iris (AUTHOR), Kalyvas, Aristotelis (AUTHOR), Stavrinou, Lampis (AUTHOR), Giannopoulos, Sotirios (AUTHOR), Boviatsis, Efstathios (AUTHOR), Tsivgoulis, Georgios (AUTHOR), Bonakis, Anastasios (AUTHOR), Knake, Susanne (AUTHOR), Tsalouchidou, Panagiota‐Eleni (AUTHOR)
Source: Epilepsia (Series 4). Feb2026, Vol. 67 Issue 2, p588-605. 18p.
Subjects: Laser surgery, Temporal lobe epilepsy, Visual memory, Verbal memory, Cognitive ability, Cognition disorders, Operative surgery
Abstract: Objective: This systematic review and meta‐analysis aimed to compare neuropsychological outcomes following traditional surgical approaches and magnetic resonance‐guided laser interstitial thermal therapy (MRgLITT) in patients with drug‐resistant mesial temporal lobe epilepsy. Methods: Thirty‐four studies were included; 24 reported cognitive outcomes following open resection, seven following MRgLITT, and three reported on both procedures. Meta‐analyses of proportions, subgroup comparisons, and meta‐regressions were conducted across three cognitive domains: verbal memory, visual memory, and naming, stratified by surgical laterality and procedure type. Results: In left‐sided surgery, verbal memory decline occurred in 36% (95% confidence interval [CI] = 28%–45%) after open resection and 29% (95% CI = 9%–62%) after MRgLITT, with no significant difference (p =.5967). For right‐sided procedures, visual memory decline was similar between open resection (16%, 95% CI = 8%–29%) and MRgLITT (19%, 95% CI = 3%–61%; p =.8027). Left‐sided naming decline was higher after open resection (43%, 95% CI = 27%–61%) than MRgLITT (9%, 95% CI = 3%–22%; p <.0001), a difference supported in subgroup and meta‐regression analyses. Exploratory meta‐regression suggested a borderline association between higher seizure freedom and greater naming decline (p =.0508), but MRgLITT retained a protective effect after adjusting for seizure outcomes (β = −1.36, 95% CI = −2.20 to −.51; p =.0016). Regardless of the approach, naming improvement occurred in 27% of patients in each group after right‐sided surgery, indicating substantial recovery when the left hemisphere is preserved. Significance: Verbal memory showed a nonsignificant trend toward better preservation with MRgLITT, whereas visual memory was comparable across approaches. MRgLITT significantly preserved naming after left‐sided surgery, offering a clear cognitive benefit over traditional open resection. [ABSTRACT FROM AUTHOR]
Copyright of Epilepsia (Series 4) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 192080322
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Neuropsychological outcomes comparing traditional surgical approaches and laser interstitial thermal therapy for refractory mesial temporal lobe epilepsy: A systematic review and meta‐analysis.
– Name: Author
  Label: Authors
  Group: Au
  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Stavrogianni%2C+Konstantina%22&quot;&gt;Stavrogianni, Konstantina&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Poprelka%2C+Katerina%22&quot;&gt;Poprelka, Katerina&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Fasilis%2C+Theodoros%22&quot;&gt;Fasilis, Theodoros&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Giannopapas%2C+Vasileios%22&quot;&gt;Giannopapas, Vasileios&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Hahn%2C+Wiebke%22&quot;&gt;Hahn, Wiebke&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Gorny%2C+Iris%22&quot;&gt;Gorny, Iris&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Kalyvas%2C+Aristotelis%22&quot;&gt;Kalyvas, Aristotelis&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Stavrinou%2C+Lampis%22&quot;&gt;Stavrinou, Lampis&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Giannopoulos%2C+Sotirios%22&quot;&gt;Giannopoulos, Sotirios&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Boviatsis%2C+Efstathios%22&quot;&gt;Boviatsis, Efstathios&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Tsivgoulis%2C+Georgios%22&quot;&gt;Tsivgoulis, Georgios&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Bonakis%2C+Anastasios%22&quot;&gt;Bonakis, Anastasios&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Knake%2C+Susanne%22&quot;&gt;Knake, Susanne&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Tsalouchidou%2C+Panagiota‐Eleni%22&quot;&gt;Tsalouchidou, Panagiota‐Eleni&lt;/searchLink&gt; (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Epilepsia+%28Series+4%29%22&quot;&gt;Epilepsia (Series 4)&lt;/searchLink&gt;. Feb2026, Vol. 67 Issue 2, p588-605. 18p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Laser+surgery%22&quot;&gt;Laser surgery&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Temporal+lobe+epilepsy%22&quot;&gt;Temporal lobe epilepsy&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Visual+memory%22&quot;&gt;Visual memory&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Verbal+memory%22&quot;&gt;Verbal memory&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Cognitive+ability%22&quot;&gt;Cognitive ability&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Cognition+disorders%22&quot;&gt;Cognition disorders&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Operative+surgery%22&quot;&gt;Operative surgery&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective: This systematic review and meta‐analysis aimed to compare neuropsychological outcomes following traditional surgical approaches and magnetic resonance‐guided laser interstitial thermal therapy (MRgLITT) in patients with drug‐resistant mesial temporal lobe epilepsy. Methods: Thirty‐four studies were included; 24 reported cognitive outcomes following open resection, seven following MRgLITT, and three reported on both procedures. Meta‐analyses of proportions, subgroup comparisons, and meta‐regressions were conducted across three cognitive domains: verbal memory, visual memory, and naming, stratified by surgical laterality and procedure type. Results: In left‐sided surgery, verbal memory decline occurred in 36% (95% confidence interval [CI] = 28%–45%) after open resection and 29% (95% CI = 9%–62%) after MRgLITT, with no significant difference (p =.5967). For right‐sided procedures, visual memory decline was similar between open resection (16%, 95% CI = 8%–29%) and MRgLITT (19%, 95% CI = 3%–61%; p =.8027). Left‐sided naming decline was higher after open resection (43%, 95% CI = 27%–61%) than MRgLITT (9%, 95% CI = 3%–22%; p &lt;.0001), a difference supported in subgroup and meta‐regression analyses. Exploratory meta‐regression suggested a borderline association between higher seizure freedom and greater naming decline (p =.0508), but MRgLITT retained a protective effect after adjusting for seizure outcomes (β = −1.36, 95% CI = −2.20 to −.51; p =.0016). Regardless of the approach, naming improvement occurred in 27% of patients in each group after right‐sided surgery, indicating substantial recovery when the left hemisphere is preserved. Significance: Verbal memory showed a nonsignificant trend toward better preservation with MRgLITT, whereas visual memory was comparable across approaches. MRgLITT significantly preserved naming after left‐sided surgery, offering a clear cognitive benefit over traditional open resection. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: &lt;i&gt;Copyright of Epilepsia (Series 4) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=192080322
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/epi.18687
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 18
        StartPage: 588
    Subjects:
      – SubjectFull: Laser surgery
        Type: general
      – SubjectFull: Temporal lobe epilepsy
        Type: general
      – SubjectFull: Visual memory
        Type: general
      – SubjectFull: Verbal memory
        Type: general
      – SubjectFull: Cognitive ability
        Type: general
      – SubjectFull: Cognition disorders
        Type: general
      – SubjectFull: Operative surgery
        Type: general
    Titles:
      – TitleFull: Neuropsychological outcomes comparing traditional surgical approaches and laser interstitial thermal therapy for refractory mesial temporal lobe epilepsy: A systematic review and meta‐analysis.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Stavrogianni, Konstantina
      – PersonEntity:
          Name:
            NameFull: Poprelka, Katerina
      – PersonEntity:
          Name:
            NameFull: Fasilis, Theodoros
      – PersonEntity:
          Name:
            NameFull: Giannopapas, Vasileios
      – PersonEntity:
          Name:
            NameFull: Hahn, Wiebke
      – PersonEntity:
          Name:
            NameFull: Gorny, Iris
      – PersonEntity:
          Name:
            NameFull: Kalyvas, Aristotelis
      – PersonEntity:
          Name:
            NameFull: Stavrinou, Lampis
      – PersonEntity:
          Name:
            NameFull: Giannopoulos, Sotirios
      – PersonEntity:
          Name:
            NameFull: Boviatsis, Efstathios
      – PersonEntity:
          Name:
            NameFull: Tsivgoulis, Georgios
      – PersonEntity:
          Name:
            NameFull: Bonakis, Anastasios
      – PersonEntity:
          Name:
            NameFull: Knake, Susanne
      – PersonEntity:
          Name:
            NameFull: Tsalouchidou, Panagiota‐Eleni
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 02
              Text: Feb2026
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-print
              Value: 00139580
          Numbering:
            – Type: volume
              Value: 67
            – Type: issue
              Value: 2
          Titles:
            – TitleFull: Epilepsia (Series 4)
              Type: main
ResultId 1