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A New Probe for the Diagnosis of Myotonic Muscular Dystrophy.

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Title: A New Probe for the Diagnosis of Myotonic Muscular Dystrophy.
Authors: BARTLETT, R. J. (AUTHOR), PERICAK-VANCE, M. A. (AUTHOR), YAMAOKA, L. (AUTHOR), GILBERT, J. (AUTHOR), HERBSTREITH, M. (AUTHOR), HUNG, W.-Y. (AUTHOR), LEE, J. E. (AUTHOR), MOHANDAS, T. (AUTHOR), BRUNS, G. (AUTHOR), LABERGE, C. (AUTHOR), THIBAULT, M.-C. (AUTHOR), Ross, D. (AUTHOR), ROSES, A. D. (AUTHOR)
Source: Science (pre-March 2025). 3/27/1987, Vol. 235 Issue 4796, p1648-1650. 3p. 4 Graphs.
Abstract: Myotonic muscular dystrophy (DM) is the most common muscular dystrophy, affecting adults as well as children. It is inherited as an autosomal dominant trait and is characterized by variable expressivity and late age-of-onset. Linkage studies have established the locus on chromosome 19. In order to identify tightly linked probes for diagnosis as well as to define in detail the DM gene region, chromosome 19 libraries were constructed and screened for restriction fragment length polymorphisms tightly linked to DM. A genomic clone, LDR152 (D19519), was isolated that is tightly linked to DM; recombination fraction = 0.0 (95% confidence limits 0.0-0.03); lod score, 15.4. [ABSTRACT FROM AUTHOR]
Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: A New Probe for the Diagnosis of Myotonic Muscular Dystrophy.
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  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 3/27/1987, Vol. 235 Issue 4796, p1648-1650. 3p. 4 Graphs.
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  Data: Myotonic muscular dystrophy (DM) is the most common muscular dystrophy, affecting adults as well as children. It is inherited as an autosomal dominant trait and is characterized by variable expressivity and late age-of-onset. Linkage studies have established the locus on chromosome 19. In order to identify tightly linked probes for diagnosis as well as to define in detail the DM gene region, chromosome 19 libraries were constructed and screened for restriction fragment length polymorphisms tightly linked to DM. A genomic clone, LDR152 (D19519), was isolated that is tightly linked to DM; recombination fraction = 0.0 (95% confidence limits 0.0-0.03); lod score, 15.4. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=192307887
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