West African HIV-2-Related Human Retrovirus with Attenuated Cytopathicity.
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| Title: | West African HIV-2-Related Human Retrovirus with Attenuated Cytopathicity. |
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| Authors: | KONG, LILLY I. (AUTHOR), LEE, SHEI-WEN (AUTHOR), KAPPES, JOHN C. (AUTHOR), PARKIN, JEFFREY S. (AUTHOR), DECKER, DON (AUTHOR), HOXIE, JAMES A. (AUTHOR), HAHN, BEATRICE H. (AUTHOR), SHAW, GEORGE M. (AUTHOR) |
| Source: | Science (pre-March 2025). 6/10/1988, Vol. 240 Issue 4858, p1525-1529. 5p. |
| Abstract: | Clinical and seroepidemiological studies in West Africa indicate that human immunodeficiency virus type 2 HIV-2 is widespread and associated with immunodeficiency states of variable degree. In this study, an isolate of HIV-2 from a patient in Senegal was molecularly cloned and characterized. This isolate HIV-2ST was shown by hybridization and restriction enzyme analysis to be more related to the prototype HIV-2ROD than to other human or primate retroviruses. Cultures of HIV-2ST showed genotypic polymorphism, and clones of the virus had transmembrane envelope glycoproteins of 30 and 42 kilodaltons. Unlike other immunodeficiency viruses, HIV-2ST did not cause cell death or induce cell fusion in peripheral blood lymphocytes or in any of four CD4+ cell lines tested. Although HIV-2ST entered cells by a CD4-dependent mechanism and replicated actively, cell-free transmission of the virus was retarded at the level of cell entry. These findings suggest that immunodeficiency viruses prevalent in West African populations are members of the HIV-2 virus group and that certain strains of this virus have attenuated virulence. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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