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Inter- and intra-hemispheric lateralization alterations in auditory verbal hallucinations of Schizophrenia: insights from resting-state functional connectivity.

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Title: Inter- and intra-hemispheric lateralization alterations in auditory verbal hallucinations of Schizophrenia: insights from resting-state functional connectivity.
Authors: Li, Jinguang (AUTHOR), He, Jingqi (AUTHOR), Ren, Honghong (AUTHOR), Li, Zongchang (AUTHOR), Ma, Xiaoqian (AUTHOR), Yuan, Liu (AUTHOR), Ouyang, Lijun (AUTHOR), Li, Chunwang (AUTHOR), He, Ying (AUTHOR), Tang, Jinsong (AUTHOR), Chen, Xiaogang (AUTHOR)
Source: European Archives of Psychiatry & Clinical Neuroscience. Apr2026, Vol. 276 Issue 3, p979-990. 12p.
Subjects: Auditory hallucinations, Schizophrenia, Cerebral dominance, Prefrontal cortex, Functional magnetic resonance imaging, Neural pathways, Temporoparietal junction, Functional connectivity
Abstract: Auditory verbal hallucinations (AVHs) in schizophrenia are hypothesized to involve alterations in hemispheric lateralization, but the specific neural mechanisms remain unclear. This study investigated functional intra- and inter-hemispheric connectivity to identify lateralization patterns unique to AVHs. Resting-state fMRI data were collected from 60 schizophrenia patients with persistent AVHs (p-AVH group), 39 patients without AVHs (n-AVH group), and 59 healthy controls (HC group). Using a homotopic atlas, we quantified lateralization indices of functional segregation and integration across 200 homotopic ROI pairs. Segregation was defined as the degree of preferential intra-hemispheric communication within each hemisphere versus inter-hemispheric communication. Integration was used to assess the extent of inter-hemispheric communication between the two hemispheres. Our findings revealed a significant rightward lateralization of segregation in two lateral prefrontal cortex homotopic pairs in the p-AVH group. Additionally, we observed a leftward lateralization of integration in an inferior parietal lobule homotopic pair within the temporoparietal junction region, specifically in the p-AVH group. Importantly, the lateralization index of segregation in the prefrontal cortex was negatively correlated with AVH severity, indicating that greater rightward lateralization is associated with more severe AVHs. These lateralization changes were absent when comparing the n-AVH group to HC group, suggesting they are unique to AVHs in schizophrenia. Our results underscore the pivotal role of altered hemispheric lateralization of functional segregation and integration in the etiology of AVHs, providing new insights into the neural mechanisms underlying these symptoms. [ABSTRACT FROM AUTHOR]
Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Inter- and intra-hemispheric lateralization alterations in auditory verbal hallucinations of Schizophrenia: insights from resting-state functional connectivity.
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  Data: <searchLink fieldCode="AR" term="%22Li%2C+Jinguang%22">Li, Jinguang</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22He%2C+Jingqi%22">He, Jingqi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ren%2C+Honghong%22">Ren, Honghong</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Zongchang%22">Li, Zongchang</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ma%2C+Xiaoqian%22">Ma, Xiaoqian</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yuan%2C+Liu%22">Yuan, Liu</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ouyang%2C+Lijun%22">Ouyang, Lijun</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Chunwang%22">Li, Chunwang</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22He%2C+Ying%22">He, Ying</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tang%2C+Jinsong%22">Tang, Jinsong</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Xiaogang%22">Chen, Xiaogang</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Archives+of+Psychiatry+%26+Clinical+Neuroscience%22">European Archives of Psychiatry & Clinical Neuroscience</searchLink>. Apr2026, Vol. 276 Issue 3, p979-990. 12p.
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– Name: Abstract
  Label: Abstract
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  Data: Auditory verbal hallucinations (AVHs) in schizophrenia are hypothesized to involve alterations in hemispheric lateralization, but the specific neural mechanisms remain unclear. This study investigated functional intra- and inter-hemispheric connectivity to identify lateralization patterns unique to AVHs. Resting-state fMRI data were collected from 60 schizophrenia patients with persistent AVHs (p-AVH group), 39 patients without AVHs (n-AVH group), and 59 healthy controls (HC group). Using a homotopic atlas, we quantified lateralization indices of functional segregation and integration across 200 homotopic ROI pairs. Segregation was defined as the degree of preferential intra-hemispheric communication within each hemisphere versus inter-hemispheric communication. Integration was used to assess the extent of inter-hemispheric communication between the two hemispheres. Our findings revealed a significant rightward lateralization of segregation in two lateral prefrontal cortex homotopic pairs in the p-AVH group. Additionally, we observed a leftward lateralization of integration in an inferior parietal lobule homotopic pair within the temporoparietal junction region, specifically in the p-AVH group. Importantly, the lateralization index of segregation in the prefrontal cortex was negatively correlated with AVH severity, indicating that greater rightward lateralization is associated with more severe AVHs. These lateralization changes were absent when comparing the n-AVH group to HC group, suggesting they are unique to AVHs in schizophrenia. Our results underscore the pivotal role of altered hemispheric lateralization of functional segregation and integration in the etiology of AVHs, providing new insights into the neural mechanisms underlying these symptoms. [ABSTRACT FROM AUTHOR]
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  Label:
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  Data: <i>Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Type: general
      – SubjectFull: Schizophrenia
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              Text: Apr2026
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