The plasma-derived exosomal Gomafu levels are associated with psychopathological symptoms and symptomatic remission in drug-naïve patients with first-episode schizophrenia.
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| Title: | The plasma-derived exosomal Gomafu levels are associated with psychopathological symptoms and symptomatic remission in drug-naïve patients with first-episode schizophrenia. |
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| Authors: | Wang, Qi (AUTHOR), Li, Li (AUTHOR), Zhao, Hongyan (AUTHOR), Dong, Xiaomei (AUTHOR), Cui, Gang (AUTHOR), Geng, Zhongli (AUTHOR), Xu, Tianchao (AUTHOR) |
| Source: | European Archives of Psychiatry & Clinical Neuroscience. Apr2026, Vol. 276 Issue 3, p1271-1280. 10p. |
| Subjects: | Schizophrenia, Biomarkers, Exosomes, Pathological psychology, Aripiprazole, Disease remission, Cognition disorders, LincRNA |
| Abstract: | Long non-coding RNA (lncRNA) Gomafu has been implicated in the onset and progression of schizophrenia. In this study, we investigated the association between the plasma-derived exosomal Gomafu levels and psychopathological symptoms, as well as symptomatic remission following short-term treatment (4 weeks), in patients with drug-naïve patients with first-episode schizophrenia (DFSZ). We measured the plasma-derived exosomal Gomafu levels in 65 DFSZ schizophrenia patients and 65 healthy matched controls. All DFSZ patients received aripiprazole treatment. Positive and Negative Syndrome Scale (PANSS) assessment was performed to evaluate the psychotic symptoms. Cognitive function was assessed using the validated Chinese version of the MATRICS Consensus Cognitive Battery (MCCB). We found that the expression level of plasma-derived exosomal Gomafu in DFSZ patients was significantly higher than in the healthy control group. Receiver operating characteristic (ROC) curve analysis demonstrated a high diagnostic value for plasma-derived exosomal Gomafu in identifying DFSZ, with an area under the curve (AUC) of 0.921. Multiple linear regression analysis results showed that duration of untreated psychosis (DUP), PANSS negative score, PANSS total score, MCCB—attention and vigilance score, MCCB—social cognition score, and MCCB—total score were independent influencing factors of the expression level of plasma-derived exosomal Gomafu in patients with DFSZ. After 4 weeks of treatment with aripiprazole, the Gomafu levels significantly decreased in DFSZ patients. Moreover, the reduction in PANSS total score was positively correlated with the decrease in Gomafu levels. The Gomafu levels at baseline of remitters was lower than that of non-remitters. ROC curve analysis further suggested that baseline Gomafu levels could predict symptomatic remission, with an AUC of 0.695. The results of our study shows that plasma-derived exosomal Gomafu levels are ssociated with psychopathological symptoms (especially negative symptoms and cognitive impairment) and symptomatic remission with short-term aripiprazole treatment. Plasma-derived exosomal Gomafu may be a biological biomarker for DFSZ. Further studies are warranted to elucidate the mechanisms linking Gomafu to schizophrenia pathophysiology. [ABSTRACT FROM AUTHOR] |
| Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 192411254 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: The plasma-derived exosomal Gomafu levels are associated with psychopathological symptoms and symptomatic remission in drug-naïve patients with first-episode schizophrenia. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Wang%2C+Qi%22">Wang, Qi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Li%22">Li, Li</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhao%2C+Hongyan%22">Zhao, Hongyan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dong%2C+Xiaomei%22">Dong, Xiaomei</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cui%2C+Gang%22">Cui, Gang</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Geng%2C+Zhongli%22">Geng, Zhongli</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xu%2C+Tianchao%22">Xu, Tianchao</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Archives+of+Psychiatry+%26+Clinical+Neuroscience%22">European Archives of Psychiatry & Clinical Neuroscience</searchLink>. Apr2026, Vol. 276 Issue 3, p1271-1280. 10p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Schizophrenia%22">Schizophrenia</searchLink><br /><searchLink fieldCode="DE" term="%22Biomarkers%22">Biomarkers</searchLink><br /><searchLink fieldCode="DE" term="%22Exosomes%22">Exosomes</searchLink><br /><searchLink fieldCode="DE" term="%22Pathological+psychology%22">Pathological psychology</searchLink><br /><searchLink fieldCode="DE" term="%22Aripiprazole%22">Aripiprazole</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+remission%22">Disease remission</searchLink><br /><searchLink fieldCode="DE" term="%22Cognition+disorders%22">Cognition disorders</searchLink><br /><searchLink fieldCode="DE" term="%22LincRNA%22">LincRNA</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Long non-coding RNA (lncRNA) Gomafu has been implicated in the onset and progression of schizophrenia. In this study, we investigated the association between the plasma-derived exosomal Gomafu levels and psychopathological symptoms, as well as symptomatic remission following short-term treatment (4 weeks), in patients with drug-naïve patients with first-episode schizophrenia (DFSZ). We measured the plasma-derived exosomal Gomafu levels in 65 DFSZ schizophrenia patients and 65 healthy matched controls. All DFSZ patients received aripiprazole treatment. Positive and Negative Syndrome Scale (PANSS) assessment was performed to evaluate the psychotic symptoms. Cognitive function was assessed using the validated Chinese version of the MATRICS Consensus Cognitive Battery (MCCB). We found that the expression level of plasma-derived exosomal Gomafu in DFSZ patients was significantly higher than in the healthy control group. Receiver operating characteristic (ROC) curve analysis demonstrated a high diagnostic value for plasma-derived exosomal Gomafu in identifying DFSZ, with an area under the curve (AUC) of 0.921. Multiple linear regression analysis results showed that duration of untreated psychosis (DUP), PANSS negative score, PANSS total score, MCCB—attention and vigilance score, MCCB—social cognition score, and MCCB—total score were independent influencing factors of the expression level of plasma-derived exosomal Gomafu in patients with DFSZ. After 4 weeks of treatment with aripiprazole, the Gomafu levels significantly decreased in DFSZ patients. Moreover, the reduction in PANSS total score was positively correlated with the decrease in Gomafu levels. The Gomafu levels at baseline of remitters was lower than that of non-remitters. ROC curve analysis further suggested that baseline Gomafu levels could predict symptomatic remission, with an AUC of 0.695. The results of our study shows that plasma-derived exosomal Gomafu levels are ssociated with psychopathological symptoms (especially negative symptoms and cognitive impairment) and symptomatic remission with short-term aripiprazole treatment. Plasma-derived exosomal Gomafu may be a biological biomarker for DFSZ. Further studies are warranted to elucidate the mechanisms linking Gomafu to schizophrenia pathophysiology. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00406-025-02023-x Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 1271 Subjects: – SubjectFull: Schizophrenia Type: general – SubjectFull: Biomarkers Type: general – SubjectFull: Exosomes Type: general – SubjectFull: Pathological psychology Type: general – SubjectFull: Aripiprazole Type: general – SubjectFull: Disease remission Type: general – SubjectFull: Cognition disorders Type: general – SubjectFull: LincRNA Type: general Titles: – TitleFull: The plasma-derived exosomal Gomafu levels are associated with psychopathological symptoms and symptomatic remission in drug-naïve patients with first-episode schizophrenia. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Wang, Qi – PersonEntity: Name: NameFull: Li, Li – PersonEntity: Name: NameFull: Zhao, Hongyan – PersonEntity: Name: NameFull: Dong, Xiaomei – PersonEntity: Name: NameFull: Cui, Gang – PersonEntity: Name: NameFull: Geng, Zhongli – PersonEntity: Name: NameFull: Xu, Tianchao IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 04 Text: Apr2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 09401334 Numbering: – Type: volume Value: 276 – Type: issue Value: 3 Titles: – TitleFull: European Archives of Psychiatry & Clinical Neuroscience Type: main |
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