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Mindfulness‐Based Stress Reduction Effects on Chemotherapy‐Induced Peripheral Neuropathy Among Breast Cancer Survivors.

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Title: Mindfulness‐Based Stress Reduction Effects on Chemotherapy‐Induced Peripheral Neuropathy Among Breast Cancer Survivors.
Authors: Poudel, Ranjita (AUTHOR), Tofthagen, Cindy S. (AUTHOR), Reich, Richard R. (AUTHOR), Rodriquez, Carmen (AUTHOR), Morgan, Sandra (AUTHOR), Krothapalli, Mahathi (AUTHOR), Tinsley‐Vance, Sara M. (AUTHOR), Park, Jong Y. (AUTHOR), Meng, Hongdao (AUTHOR), Kip, Kevin E. (AUTHOR), Lin, Katherine J. (AUTHOR), Chamkeri, Ramya (AUTHOR), Nidamanur, Sreenidhi (AUTHOR), Lengacher, Cecile A. (AUTHOR)
Source: Psycho-Oncology. Mar2026, Vol. 35 Issue 3, p1-11. 11p.
Subjects: Chemotherapy complications, Peripheral neuropathy, Quality of life, Mindfulness, Symptoms, Cancer survivors, Randomized controlled trials, Self-management (Psychology)
Abstract: Background: Chemotherapy‐induced peripheral neuropathy (CIPN), characterized by loss of sensation and impaired physical function, is a prevalent and debilitating side effect of chemotherapy, affecting 30%–50% of breast cancer survivors (BCS) with effects lasting years after treatment completion. Mindfulness‐based interventions are shown to be efficacious in reducing symptoms in neuropathies. This subgroup analysis examined the effect of Mindfulness‐Based Stress Reduction on Breast Cancer (MBSR(BC)) compared to Breast Cancer Education Support (BCES) or Usual Care (UC) on CIPN among BCS who received chemotherapy or chemotherapy and radiation. Methods: BCS (n = 114) were randomly assigned to the 6‐week MBSR(BC) (n = 48), BCES (n = 52), or UC (n = 14) regimen. Demographic and clinical data were assessed at baseline, and CIPN was assessed using the Chemotherapy‐Induced Peripheral Neuropathy assessment tool (CIPNAT) at baseline, 6, 12, and 26 weeks. Between‐ and within‐group differences were evaluated and change over time was compared between groups. Results: BCS (mean age = 52.7 years, range: 28–81 years) were primarily White and non‐Hispanic (n = 78, 68%). The pattern of effect sizes was similar for CIPNAT symptoms and interference with improvements in CIPN for MBSR(BC) and BCES groups overtime. For both groups, the effects were larger compared to the UC. Differences tended to increase over time with significant effects observed between MBSR(BC) and UC, and between BCES and UC at weeks 12 and 26. Conclusions: The findings indicate that MBSR(BC) and BCES may effectively reduce CIPN symptoms among BCS compared to UC. MBSR(BC) and BCES programs are effective non‐pharmacological interventions for CIPN that may translate into practice. [ABSTRACT FROM AUTHOR]
Copyright of Psycho-Oncology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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PubType: Academic Journal
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  Data: Mindfulness‐Based Stress Reduction Effects on Chemotherapy‐Induced Peripheral Neuropathy Among Breast Cancer Survivors.
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  Label: Authors
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  Data: <searchLink fieldCode="AR" term="%22Poudel%2C+Ranjita%22">Poudel, Ranjita</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tofthagen%2C+Cindy+S%2E%22">Tofthagen, Cindy S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Reich%2C+Richard+R%2E%22">Reich, Richard R.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rodriquez%2C+Carmen%22">Rodriquez, Carmen</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Morgan%2C+Sandra%22">Morgan, Sandra</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Krothapalli%2C+Mahathi%22">Krothapalli, Mahathi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tinsley‐Vance%2C+Sara+M%2E%22">Tinsley‐Vance, Sara M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Park%2C+Jong+Y%2E%22">Park, Jong Y.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Meng%2C+Hongdao%22">Meng, Hongdao</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kip%2C+Kevin+E%2E%22">Kip, Kevin E.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lin%2C+Katherine+J%2E%22">Lin, Katherine J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chamkeri%2C+Ramya%22">Chamkeri, Ramya</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nidamanur%2C+Sreenidhi%22">Nidamanur, Sreenidhi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lengacher%2C+Cecile+A%2E%22">Lengacher, Cecile A.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Psycho-Oncology%22">Psycho-Oncology</searchLink>. Mar2026, Vol. 35 Issue 3, p1-11. 11p.
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  Data: <searchLink fieldCode="DE" term="%22Chemotherapy+complications%22">Chemotherapy complications</searchLink><br /><searchLink fieldCode="DE" term="%22Peripheral+neuropathy%22">Peripheral neuropathy</searchLink><br /><searchLink fieldCode="DE" term="%22Quality+of+life%22">Quality of life</searchLink><br /><searchLink fieldCode="DE" term="%22Mindfulness%22">Mindfulness</searchLink><br /><searchLink fieldCode="DE" term="%22Symptoms%22">Symptoms</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+survivors%22">Cancer survivors</searchLink><br /><searchLink fieldCode="DE" term="%22Randomized+controlled+trials%22">Randomized controlled trials</searchLink><br /><searchLink fieldCode="DE" term="%22Self-management+%28Psychology%29%22">Self-management (Psychology)</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Chemotherapy‐induced peripheral neuropathy (CIPN), characterized by loss of sensation and impaired physical function, is a prevalent and debilitating side effect of chemotherapy, affecting 30%–50% of breast cancer survivors (BCS) with effects lasting years after treatment completion. Mindfulness‐based interventions are shown to be efficacious in reducing symptoms in neuropathies. This subgroup analysis examined the effect of Mindfulness‐Based Stress Reduction on Breast Cancer (MBSR(BC)) compared to Breast Cancer Education Support (BCES) or Usual Care (UC) on CIPN among BCS who received chemotherapy or chemotherapy and radiation. Methods: BCS (n = 114) were randomly assigned to the 6‐week MBSR(BC) (n = 48), BCES (n = 52), or UC (n = 14) regimen. Demographic and clinical data were assessed at baseline, and CIPN was assessed using the Chemotherapy‐Induced Peripheral Neuropathy assessment tool (CIPNAT) at baseline, 6, 12, and 26 weeks. Between‐ and within‐group differences were evaluated and change over time was compared between groups. Results: BCS (mean age = 52.7 years, range: 28–81 years) were primarily White and non‐Hispanic (n = 78, 68%). The pattern of effect sizes was similar for CIPNAT symptoms and interference with improvements in CIPN for MBSR(BC) and BCES groups overtime. For both groups, the effects were larger compared to the UC. Differences tended to increase over time with significant effects observed between MBSR(BC) and UC, and between BCES and UC at weeks 12 and 26. Conclusions: The findings indicate that MBSR(BC) and BCES may effectively reduce CIPN symptoms among BCS compared to UC. MBSR(BC) and BCES programs are effective non‐pharmacological interventions for CIPN that may translate into practice. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of Psycho-Oncology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1002/pon.70427
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      – Code: eng
        Text: English
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        PageCount: 11
        StartPage: 1
    Subjects:
      – SubjectFull: Chemotherapy complications
        Type: general
      – SubjectFull: Peripheral neuropathy
        Type: general
      – SubjectFull: Quality of life
        Type: general
      – SubjectFull: Mindfulness
        Type: general
      – SubjectFull: Symptoms
        Type: general
      – SubjectFull: Cancer survivors
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      – SubjectFull: Randomized controlled trials
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      – SubjectFull: Self-management (Psychology)
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      – TitleFull: Mindfulness‐Based Stress Reduction Effects on Chemotherapy‐Induced Peripheral Neuropathy Among Breast Cancer Survivors.
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              Text: Mar2026
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