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Gait Parameters Alterations Under Dual‐Task Conditions in Patients With Acquired and Hereditary Peripheral Neuropathies.

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Title: Gait Parameters Alterations Under Dual‐Task Conditions in Patients With Acquired and Hereditary Peripheral Neuropathies.
Authors: Dupont, Loïc (AUTHOR), Thomas, Romain (AUTHOR), Danjoux, Loïc (AUTHOR), Cailleret, Madeline (AUTHOR), Davion, Jean‐Baptiste (AUTHOR), Defebvre, Luc (AUTHOR), Delval, Arnaud (AUTHOR), Tard, Céline (AUTHOR)
Source: European Journal of Neurology. Mar2026, Vol. 33 Issue 3, p1-9. 9p.
Subjects: Chronic inflammatory demyelinating polyradiculoneuropathy, Charcot-Marie-Tooth disease, Cognitive load, Human locomotion, Peripheral neuropathy, Dual-task paradigm
Abstract: Introduction: Peripheral demyelinating neuropathies impair gait and increase fall risk, particularly under cognitively demanding conditions. While gait disturbances in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and Charcot–Marie–Tooth disease type 1A (CMT1A) are well documented, their differential responses to cognitive dual‐tasking remain poorly understood. Methods: In this prospective study, 62 patients (31 CIDP, 31 CMT1A) performed 10‐m barefoot walking trials under three conditions: natural walking, low dual‐task (answering factual questions), and high dual‐task (introspective questions about illness impact). Gait parameters, including speed, stride length, stride time, foot and heel clearance, were measured using a motion capture system. Group, condition, and interaction effects were analyzed using linear mixed‐effects models. Results: Both groups showed significant reductions in gait speed and stride length under dual‐task conditions. Compared to CMT1A, CIDP patients exhibited more pronounced slowing and increased stride time, especially during high dual‐tasking. Heel clearance decreased significantly in CIDP, with a group × condition interaction, while CMT1A patients maintained more stable gait patterns. Foot clearance at peak swing declined in both groups without intergroup differences. Discussion: These results suggest that CIDP patients adopt a more cautious gait under cognitive load, reflecting reduced automatism and adaptability. In contrast, CMT1A patients appear to benefit from long‐term compensatory strategies developed over the disease course. Moreover, the CIDP patients decreased their heel clearance during dual‐task, increasing the fall risk. Conclusion: Dual‐task gait analysis reveals distinct adaptations in hereditary and acquired neuropathies. Parameters such as heel clearance and stride time may serve as functional markers to guide diagnosis and rehabilitation. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Gait Parameters Alterations Under Dual‐Task Conditions in Patients With Acquired and Hereditary Peripheral Neuropathies.
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  Data: <searchLink fieldCode="AR" term="%22Dupont%2C+Loïc%22">Dupont, Loïc</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Thomas%2C+Romain%22">Thomas, Romain</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Danjoux%2C+Loïc%22">Danjoux, Loïc</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cailleret%2C+Madeline%22">Cailleret, Madeline</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Davion%2C+Jean‐Baptiste%22">Davion, Jean‐Baptiste</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Defebvre%2C+Luc%22">Defebvre, Luc</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Delval%2C+Arnaud%22">Delval, Arnaud</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tard%2C+Céline%22">Tard, Céline</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neurology%22">European Journal of Neurology</searchLink>. Mar2026, Vol. 33 Issue 3, p1-9. 9p.
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  Data: <searchLink fieldCode="DE" term="%22Chronic+inflammatory+demyelinating+polyradiculoneuropathy%22">Chronic inflammatory demyelinating polyradiculoneuropathy</searchLink><br /><searchLink fieldCode="DE" term="%22Charcot-Marie-Tooth+disease%22">Charcot-Marie-Tooth disease</searchLink><br /><searchLink fieldCode="DE" term="%22Cognitive+load%22">Cognitive load</searchLink><br /><searchLink fieldCode="DE" term="%22Human+locomotion%22">Human locomotion</searchLink><br /><searchLink fieldCode="DE" term="%22Peripheral+neuropathy%22">Peripheral neuropathy</searchLink><br /><searchLink fieldCode="DE" term="%22Dual-task+paradigm%22">Dual-task paradigm</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Introduction: Peripheral demyelinating neuropathies impair gait and increase fall risk, particularly under cognitively demanding conditions. While gait disturbances in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and Charcot–Marie–Tooth disease type 1A (CMT1A) are well documented, their differential responses to cognitive dual‐tasking remain poorly understood. Methods: In this prospective study, 62 patients (31 CIDP, 31 CMT1A) performed 10‐m barefoot walking trials under three conditions: natural walking, low dual‐task (answering factual questions), and high dual‐task (introspective questions about illness impact). Gait parameters, including speed, stride length, stride time, foot and heel clearance, were measured using a motion capture system. Group, condition, and interaction effects were analyzed using linear mixed‐effects models. Results: Both groups showed significant reductions in gait speed and stride length under dual‐task conditions. Compared to CMT1A, CIDP patients exhibited more pronounced slowing and increased stride time, especially during high dual‐tasking. Heel clearance decreased significantly in CIDP, with a group × condition interaction, while CMT1A patients maintained more stable gait patterns. Foot clearance at peak swing declined in both groups without intergroup differences. Discussion: These results suggest that CIDP patients adopt a more cautious gait under cognitive load, reflecting reduced automatism and adaptability. In contrast, CMT1A patients appear to benefit from long‐term compensatory strategies developed over the disease course. Moreover, the CIDP patients decreased their heel clearance during dual‐task, increasing the fall risk. Conclusion: Dual‐task gait analysis reveals distinct adaptations in hereditary and acquired neuropathies. Parameters such as heel clearance and stride time may serve as functional markers to guide diagnosis and rehabilitation. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1111/ene.70518
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      – SubjectFull: Cognitive load
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      – SubjectFull: Human locomotion
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      – SubjectFull: Peripheral neuropathy
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      – SubjectFull: Dual-task paradigm
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      – TitleFull: Gait Parameters Alterations Under Dual‐Task Conditions in Patients With Acquired and Hereditary Peripheral Neuropathies.
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              Text: Mar2026
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