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Clinical and Pathological Features of Vasculitic Neuropathy: A Single‐Center Study in China.

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Title: Clinical and Pathological Features of Vasculitic Neuropathy: A Single‐Center Study in China.
Authors: Zhou, Xiaoyu (AUTHOR), Shan, Didi (AUTHOR), Wu, Bin (AUTHOR), Liu, Fuchen (AUTHOR), Zhang, Dong (AUTHOR), Lin, Pengfei (AUTHOR), Li, Wei (AUTHOR), Zhao, Yuying (AUTHOR), Yan, Chuanzhu (AUTHOR), Xu, Jingwen (AUTHOR)
Source: European Journal of Neurology. Mar2026, Vol. 33 Issue 3, p1-13. 13p.
Subjects: Biopsy, Churg-Strauss syndrome, Peripheral nervous system, Vascular diseases, Prognosis, Symptoms, Immunosuppressive agents
Geographic Terms: China
Abstract: Background: Vasculitic neuropathy (VN) is a disease in which vessel inflammation happens and injures peripheral nerves. Despite increasing awareness, features of VN in mainland China are still understudied. Objective: To characterize the clinical, pathological features and outcomes of VN in mainland China, and evaluate clinicopathological correlations: Methods: We retrospectively reviewed records of VN patients diagnosed pathologically between June 1999 and December 2024, including demographic data, clinical manifestations, biopsy features, and outcomes. Results: 112 patients were totally included. All presented with axonal sensorimotor neuropathy, most commonly involving the tibial (90.63%) and peroneal (87.50%) nerves. Systemic VN (SVN) showed more frequent transmural inflammatory cell infiltration (ICI) than non‐systemic VN (NSVN) (p = 0.046). Eosinophilic granulomatosis with polyangiitis (EGPA) was more common in VN without ICI than VN with ICI (p = 0.008). In SVN, the ICI‐positive exhibited more severe distal upper limb weakness (p = 0.042) and higher thrombosis rates (p = 0.001) than ICI‐negative. Of the 63 patients followed, 62 received glucocorticoids with or without immunosuppressants. Thirteen died from multi‐organ complications (12 SVN and 1 NSVN), while others achieved remission. The 5‐year all‐survival rate was 80.23% (95% CI 66.83%– 88.66%). Conclusions: This first large cohort of VN in mainland China delineates its clinical–pathological features. EGPA showed a lower diagnostic yield on biopsy, suggesting diverse mechanisms of vascular injury. Nerve biopsy remains the diagnostic gold standard. The overall prognosis of VN is relatively favorable, emphasizing the need for early recognition and treatment. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Label: Title
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  Data: Clinical and Pathological Features of Vasculitic Neuropathy: A Single‐Center Study in China.
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  Data: <searchLink fieldCode="AR" term="%22Zhou%2C+Xiaoyu%22">Zhou, Xiaoyu</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shan%2C+Didi%22">Shan, Didi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wu%2C+Bin%22">Wu, Bin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Fuchen%22">Liu, Fuchen</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Dong%22">Zhang, Dong</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lin%2C+Pengfei%22">Lin, Pengfei</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Wei%22">Li, Wei</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhao%2C+Yuying%22">Zhao, Yuying</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yan%2C+Chuanzhu%22">Yan, Chuanzhu</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xu%2C+Jingwen%22">Xu, Jingwen</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neurology%22">European Journal of Neurology</searchLink>. Mar2026, Vol. 33 Issue 3, p1-13. 13p.
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  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Biopsy%22">Biopsy</searchLink><br /><searchLink fieldCode="DE" term="%22Churg-Strauss+syndrome%22">Churg-Strauss syndrome</searchLink><br /><searchLink fieldCode="DE" term="%22Peripheral+nervous+system%22">Peripheral nervous system</searchLink><br /><searchLink fieldCode="DE" term="%22Vascular+diseases%22">Vascular diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Prognosis%22">Prognosis</searchLink><br /><searchLink fieldCode="DE" term="%22Symptoms%22">Symptoms</searchLink><br /><searchLink fieldCode="DE" term="%22Immunosuppressive+agents%22">Immunosuppressive agents</searchLink>
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  Group: Su
  Data: <searchLink fieldCode="DE" term="%22China%22">China</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Vasculitic neuropathy (VN) is a disease in which vessel inflammation happens and injures peripheral nerves. Despite increasing awareness, features of VN in mainland China are still understudied. Objective: To characterize the clinical, pathological features and outcomes of VN in mainland China, and evaluate clinicopathological correlations: Methods: We retrospectively reviewed records of VN patients diagnosed pathologically between June 1999 and December 2024, including demographic data, clinical manifestations, biopsy features, and outcomes. Results: 112 patients were totally included. All presented with axonal sensorimotor neuropathy, most commonly involving the tibial (90.63%) and peroneal (87.50%) nerves. Systemic VN (SVN) showed more frequent transmural inflammatory cell infiltration (ICI) than non‐systemic VN (NSVN) (p = 0.046). Eosinophilic granulomatosis with polyangiitis (EGPA) was more common in VN without ICI than VN with ICI (p = 0.008). In SVN, the ICI‐positive exhibited more severe distal upper limb weakness (p = 0.042) and higher thrombosis rates (p = 0.001) than ICI‐negative. Of the 63 patients followed, 62 received glucocorticoids with or without immunosuppressants. Thirteen died from multi‐organ complications (12 SVN and 1 NSVN), while others achieved remission. The 5‐year all‐survival rate was 80.23% (95% CI 66.83%– 88.66%). Conclusions: This first large cohort of VN in mainland China delineates its clinical–pathological features. EGPA showed a lower diagnostic yield on biopsy, suggesting diverse mechanisms of vascular injury. Nerve biopsy remains the diagnostic gold standard. The overall prognosis of VN is relatively favorable, emphasizing the need for early recognition and treatment. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1111/ene.70540
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      – Code: eng
        Text: English
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        PageCount: 13
        StartPage: 1
    Subjects:
      – SubjectFull: Biopsy
        Type: general
      – SubjectFull: Churg-Strauss syndrome
        Type: general
      – SubjectFull: Peripheral nervous system
        Type: general
      – SubjectFull: Vascular diseases
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      – SubjectFull: Prognosis
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      – SubjectFull: Symptoms
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      – SubjectFull: Immunosuppressive agents
        Type: general
      – SubjectFull: China
        Type: general
    Titles:
      – TitleFull: Clinical and Pathological Features of Vasculitic Neuropathy: A Single‐Center Study in China.
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            NameFull: Zhou, Xiaoyu
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              Text: Mar2026
              Type: published
              Y: 2026
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