View in EDS

pH‐Dependent Microenvironmental Ionic Signaling in Pancreatic Ductal Adenocarcinoma.

Saved in:
Bibliographic Details
Title: pH‐Dependent Microenvironmental Ionic Signaling in Pancreatic Ductal Adenocarcinoma.
Authors: Schwab, Albrecht (AUTHOR), Rugi, Micol (AUTHOR), Swietach, Pawel (AUTHOR), Błaszczak, Wiktoria (AUTHOR), Novak, Ivana (AUTHOR), Deshar, Ganga (AUTHOR), Pedersen, Stine Falsig (AUTHOR), Ialchina, Renata (AUTHOR), Sandelin, Albin (AUTHOR), Yao, Jiayi (AUTHOR), Reshkin, Stephan J. (AUTHOR), Cardone, Rosa A. (AUTHOR), Carvalho, Tiago M. A. (AUTHOR), Arcangeli, Annarosa (AUTHOR), Bouazzi, Rayhana (AUTHOR), D'Alessandro, Franco N. (AUTHOR), Prevarskaya, Natalia (AUTHOR), Audero, Madelaine M. (AUTHOR), Ouadid‐Ahidouch, Halima (AUTHOR), Schnipper, Julie (AUTHOR)
Source: Acta Physiologica. Apr2026, Vol. 242 Issue 4, p1-11. 11p.
Subjects: Tumor microenvironment, Ion transport (Biology), Cancer invasiveness, Immunity, Acid-base chemistry, Drug target, Pancreatic adenocarcinoma, Carrier proteins
Abstract: Aim: Pancreatic ductal adenocarcinoma (PDAC) develops within a uniquely dynamic pH landscape shaped by substantial acid–base fluxes produced by the exocrine pancreas. Secretion of alkaline pancreatic juice, normally linked to digestion, produces intermittent acidifications of the pancreatic interstitium, which challenges epithelial and stromal cells. It was postulated that these unique pancreatic pH dynamics can facilitate PDAC initiation and progression through selection of a more aggressive phenotype emerging with PDAC driver mutations. Methods: Here, we summarize evidence that pH‐regulatory transport proteins have an important role in shaping the PDAC microenvironment. Results: pH‐regulatory transport proteins generate and sense their microenvironment and act as signaling hubs to regulate proliferation, migration, and metabolism, and immune evasion. In this way, transport proteins that are crucial for the normal physiology of the exocrine pancreas are misused and become coerced into playing a pro‐cancer role in pancreatic tumor cells, pancreatic stellate cells, or infiltrating immune cells. Experiments with PDAC mouse models revealed a therapeutic potential of targeting pH dynamics, notably by inhibition or genetic ablation of pH‐regulatory proteins. It is a consistent finding that these maneuvers have a marked impact on the tumor immune defense and the communication between cancer and immune cells. Conclusion: Collectively, we present a case for considering pH‐regulating proteins as a therapeutic avenue. [ABSTRACT FROM AUTHOR]
Copyright of Acta Physiologica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 192593341
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: pH‐Dependent Microenvironmental Ionic Signaling in Pancreatic Ductal Adenocarcinoma.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Schwab%2C+Albrecht%22">Schwab, Albrecht</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rugi%2C+Micol%22">Rugi, Micol</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Swietach%2C+Pawel%22">Swietach, Pawel</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Błaszczak%2C+Wiktoria%22">Błaszczak, Wiktoria</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Novak%2C+Ivana%22">Novak, Ivana</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Deshar%2C+Ganga%22">Deshar, Ganga</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pedersen%2C+Stine+Falsig%22">Pedersen, Stine Falsig</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ialchina%2C+Renata%22">Ialchina, Renata</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sandelin%2C+Albin%22">Sandelin, Albin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yao%2C+Jiayi%22">Yao, Jiayi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Reshkin%2C+Stephan+J%2E%22">Reshkin, Stephan J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cardone%2C+Rosa+A%2E%22">Cardone, Rosa A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Carvalho%2C+Tiago+M%2E+A%2E%22">Carvalho, Tiago M. A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Arcangeli%2C+Annarosa%22">Arcangeli, Annarosa</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bouazzi%2C+Rayhana%22">Bouazzi, Rayhana</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22D'Alessandro%2C+Franco+N%2E%22">D'Alessandro, Franco N.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Prevarskaya%2C+Natalia%22">Prevarskaya, Natalia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Audero%2C+Madelaine+M%2E%22">Audero, Madelaine M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ouadid‐Ahidouch%2C+Halima%22">Ouadid‐Ahidouch, Halima</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schnipper%2C+Julie%22">Schnipper, Julie</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Acta+Physiologica%22">Acta Physiologica</searchLink>. Apr2026, Vol. 242 Issue 4, p1-11. 11p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Tumor+microenvironment%22">Tumor microenvironment</searchLink><br /><searchLink fieldCode="DE" term="%22Ion+transport+%28Biology%29%22">Ion transport (Biology)</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+invasiveness%22">Cancer invasiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Immunity%22">Immunity</searchLink><br /><searchLink fieldCode="DE" term="%22Acid-base+chemistry%22">Acid-base chemistry</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+target%22">Drug target</searchLink><br /><searchLink fieldCode="DE" term="%22Pancreatic+adenocarcinoma%22">Pancreatic adenocarcinoma</searchLink><br /><searchLink fieldCode="DE" term="%22Carrier+proteins%22">Carrier proteins</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Aim: Pancreatic ductal adenocarcinoma (PDAC) develops within a uniquely dynamic pH landscape shaped by substantial acid–base fluxes produced by the exocrine pancreas. Secretion of alkaline pancreatic juice, normally linked to digestion, produces intermittent acidifications of the pancreatic interstitium, which challenges epithelial and stromal cells. It was postulated that these unique pancreatic pH dynamics can facilitate PDAC initiation and progression through selection of a more aggressive phenotype emerging with PDAC driver mutations. Methods: Here, we summarize evidence that pH‐regulatory transport proteins have an important role in shaping the PDAC microenvironment. Results: pH‐regulatory transport proteins generate and sense their microenvironment and act as signaling hubs to regulate proliferation, migration, and metabolism, and immune evasion. In this way, transport proteins that are crucial for the normal physiology of the exocrine pancreas are misused and become coerced into playing a pro‐cancer role in pancreatic tumor cells, pancreatic stellate cells, or infiltrating immune cells. Experiments with PDAC mouse models revealed a therapeutic potential of targeting pH dynamics, notably by inhibition or genetic ablation of pH‐regulatory proteins. It is a consistent finding that these maneuvers have a marked impact on the tumor immune defense and the communication between cancer and immune cells. Conclusion: Collectively, we present a case for considering pH‐regulating proteins as a therapeutic avenue. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Acta Physiologica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=192593341
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/apha.70183
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 11
        StartPage: 1
    Subjects:
      – SubjectFull: Tumor microenvironment
        Type: general
      – SubjectFull: Ion transport (Biology)
        Type: general
      – SubjectFull: Cancer invasiveness
        Type: general
      – SubjectFull: Immunity
        Type: general
      – SubjectFull: Acid-base chemistry
        Type: general
      – SubjectFull: Drug target
        Type: general
      – SubjectFull: Pancreatic adenocarcinoma
        Type: general
      – SubjectFull: Carrier proteins
        Type: general
    Titles:
      – TitleFull: pH‐Dependent Microenvironmental Ionic Signaling in Pancreatic Ductal Adenocarcinoma.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Schwab, Albrecht
      – PersonEntity:
          Name:
            NameFull: Rugi, Micol
      – PersonEntity:
          Name:
            NameFull: Swietach, Pawel
      – PersonEntity:
          Name:
            NameFull: Błaszczak, Wiktoria
      – PersonEntity:
          Name:
            NameFull: Novak, Ivana
      – PersonEntity:
          Name:
            NameFull: Deshar, Ganga
      – PersonEntity:
          Name:
            NameFull: Pedersen, Stine Falsig
      – PersonEntity:
          Name:
            NameFull: Ialchina, Renata
      – PersonEntity:
          Name:
            NameFull: Sandelin, Albin
      – PersonEntity:
          Name:
            NameFull: Yao, Jiayi
      – PersonEntity:
          Name:
            NameFull: Reshkin, Stephan J.
      – PersonEntity:
          Name:
            NameFull: Cardone, Rosa A.
      – PersonEntity:
          Name:
            NameFull: Carvalho, Tiago M. A.
      – PersonEntity:
          Name:
            NameFull: Arcangeli, Annarosa
      – PersonEntity:
          Name:
            NameFull: Bouazzi, Rayhana
      – PersonEntity:
          Name:
            NameFull: D'Alessandro, Franco N.
      – PersonEntity:
          Name:
            NameFull: Prevarskaya, Natalia
      – PersonEntity:
          Name:
            NameFull: Audero, Madelaine M.
      – PersonEntity:
          Name:
            NameFull: Ouadid‐Ahidouch, Halima
      – PersonEntity:
          Name:
            NameFull: Schnipper, Julie
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 04
              Text: Apr2026
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-print
              Value: 17481708
          Numbering:
            – Type: volume
              Value: 242
            – Type: issue
              Value: 4
          Titles:
            – TitleFull: Acta Physiologica
              Type: main
ResultId 1