View in EDS

Prognostic value of cardiac troponin I in acute ischemic stroke patients treated with reperfusion therapy: a multicenter retrospective cohort study.

Saved in:
Bibliographic Details
Title: Prognostic value of cardiac troponin I in acute ischemic stroke patients treated with reperfusion therapy: a multicenter retrospective cohort study.
Authors: Loggini, Andrea (AUTHOR), Bonin Pinto, Camila (AUTHOR), Von Hagn, Heather (AUTHOR), Boada Robayo, Laura (AUTHOR), Schwertman, Amber (AUTHOR), Pixley, Kaitlyn (AUTHOR), Nagai, Michiaki (AUTHOR), Sajid, Ayesha (AUTHOR), Lawson, Trace (AUTHOR), Saleh Velez, Faddi G. (AUTHOR)
Source: International Journal of Neuroscience. Apr2026, Vol. 136 Issue 4, p530-537. 8p.
Subjects: Troponin I, Prognosis, Stroke patients, Hospital mortality, Ischemic stroke, Treatment effectiveness, Functional status, Reperfusion
Abstract: Background: We aimed to evaluate the association between elevated cardiac troponin I (cTnI) and clinical outcomes in AIS patients receiving reperfusion therapy. Methods: We conducted a multicenter retrospective cohort study of AIS patients treated with thrombolytics at Southern Illinois Healthcare and the University of Oklahoma (2017–2024). Demographic, clinical, laboratory, and radiographic data were collected. Elevation of cTnI was defined as levels above 0.028 ng/mL. For high sensitivity troponins, the cutoff was 15 ng/L for women and 20 ng/L for men. Outcomes included symptomatic intracranial hemorrhage (sICH), in-hospital mortality, and functional status at 30 days (good outcome defined as mRS ≤2). Overlap-weighted multivariable logistic regression was performed, adjusting for demographics, comorbidities, and stroke severity. Results: Among 496 patients, 143 (29%) had elevated cTnI. Compared with patients with normal cTnI, those with elevated levels were older, had more vascular risk factors, and higher baseline NIHSS. Elevated cTnI was not significantly associated with sICH (OR:3.75, 95%CI 0.52–27.21, p = 0.19), but was independently associated with increased in-hospital mortality (OR:1.96, 95%CI 1.62–6.20, p = 0.025) and decreased odds of good functional outcome at 30 days (OR:0.40, 95%CI 0.19–0.84, p = 0.016). Subgroup analyses showed these associations were most pronounced in older patients and in those with moderate (NIHSS 6–15) to severe (NIHSS 16–20 and > 20) strokes, whereas no significant relationships were observed in younger patients or mild strokes. Normalization of cTnI during hospitalization did not improve survival (p > 0.05). Conclusions: In our study, elevated cTnI on admission is an independent predictor of poor short-term outcomes in AIS patients treated with reperfusion therapy. Troponin measurement may provide important prognostic information, particularly in older patients and those with more severe strokes. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 192628533
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Prognostic value of cardiac troponin I in acute ischemic stroke patients treated with reperfusion therapy: a multicenter retrospective cohort study.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Loggini%2C+Andrea%22">Loggini, Andrea</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bonin+Pinto%2C+Camila%22">Bonin Pinto, Camila</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Von+Hagn%2C+Heather%22">Von Hagn, Heather</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Boada+Robayo%2C+Laura%22">Boada Robayo, Laura</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schwertman%2C+Amber%22">Schwertman, Amber</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pixley%2C+Kaitlyn%22">Pixley, Kaitlyn</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nagai%2C+Michiaki%22">Nagai, Michiaki</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sajid%2C+Ayesha%22">Sajid, Ayesha</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lawson%2C+Trace%22">Lawson, Trace</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Saleh+Velez%2C+Faddi+G%2E%22">Saleh Velez, Faddi G.</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Neuroscience%22">International Journal of Neuroscience</searchLink>. Apr2026, Vol. 136 Issue 4, p530-537. 8p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Troponin+I%22">Troponin I</searchLink><br /><searchLink fieldCode="DE" term="%22Prognosis%22">Prognosis</searchLink><br /><searchLink fieldCode="DE" term="%22Stroke+patients%22">Stroke patients</searchLink><br /><searchLink fieldCode="DE" term="%22Hospital+mortality%22">Hospital mortality</searchLink><br /><searchLink fieldCode="DE" term="%22Ischemic+stroke%22">Ischemic stroke</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Functional+status%22">Functional status</searchLink><br /><searchLink fieldCode="DE" term="%22Reperfusion%22">Reperfusion</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: We aimed to evaluate the association between elevated cardiac troponin I (cTnI) and clinical outcomes in AIS patients receiving reperfusion therapy. Methods: We conducted a multicenter retrospective cohort study of AIS patients treated with thrombolytics at Southern Illinois Healthcare and the University of Oklahoma (2017–2024). Demographic, clinical, laboratory, and radiographic data were collected. Elevation of cTnI was defined as levels above 0.028 ng/mL. For high sensitivity troponins, the cutoff was 15 ng/L for women and 20 ng/L for men. Outcomes included symptomatic intracranial hemorrhage (sICH), in-hospital mortality, and functional status at 30 days (good outcome defined as mRS ≤2). Overlap-weighted multivariable logistic regression was performed, adjusting for demographics, comorbidities, and stroke severity. Results: Among 496 patients, 143 (29%) had elevated cTnI. Compared with patients with normal cTnI, those with elevated levels were older, had more vascular risk factors, and higher baseline NIHSS. Elevated cTnI was not significantly associated with sICH (OR:3.75, 95%CI 0.52–27.21, p = 0.19), but was independently associated with increased in-hospital mortality (OR:1.96, 95%CI 1.62–6.20, p = 0.025) and decreased odds of good functional outcome at 30 days (OR:0.40, 95%CI 0.19–0.84, p = 0.016). Subgroup analyses showed these associations were most pronounced in older patients and in those with moderate (NIHSS 6–15) to severe (NIHSS 16–20 and > 20) strokes, whereas no significant relationships were observed in younger patients or mild strokes. Normalization of cTnI during hospitalization did not improve survival (p > 0.05). Conclusions: In our study, elevated cTnI on admission is an independent predictor of poor short-term outcomes in AIS patients treated with reperfusion therapy. Troponin measurement may provide important prognostic information, particularly in older patients and those with more severe strokes. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=192628533
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/00207454.2025.2589395
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 8
        StartPage: 530
    Subjects:
      – SubjectFull: Troponin I
        Type: general
      – SubjectFull: Prognosis
        Type: general
      – SubjectFull: Stroke patients
        Type: general
      – SubjectFull: Hospital mortality
        Type: general
      – SubjectFull: Ischemic stroke
        Type: general
      – SubjectFull: Treatment effectiveness
        Type: general
      – SubjectFull: Functional status
        Type: general
      – SubjectFull: Reperfusion
        Type: general
    Titles:
      – TitleFull: Prognostic value of cardiac troponin I in acute ischemic stroke patients treated with reperfusion therapy: a multicenter retrospective cohort study.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Loggini, Andrea
      – PersonEntity:
          Name:
            NameFull: Bonin Pinto, Camila
      – PersonEntity:
          Name:
            NameFull: Von Hagn, Heather
      – PersonEntity:
          Name:
            NameFull: Boada Robayo, Laura
      – PersonEntity:
          Name:
            NameFull: Schwertman, Amber
      – PersonEntity:
          Name:
            NameFull: Pixley, Kaitlyn
      – PersonEntity:
          Name:
            NameFull: Nagai, Michiaki
      – PersonEntity:
          Name:
            NameFull: Sajid, Ayesha
      – PersonEntity:
          Name:
            NameFull: Lawson, Trace
      – PersonEntity:
          Name:
            NameFull: Saleh Velez, Faddi G.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 04
              Text: Apr2026
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-print
              Value: 00207454
          Numbering:
            – Type: volume
              Value: 136
            – Type: issue
              Value: 4
          Titles:
            – TitleFull: International Journal of Neuroscience
              Type: main
ResultId 1