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Outcomes of deprescribing for people with life-limiting conditions: A systematic review.

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Title: Outcomes of deprescribing for people with life-limiting conditions: A systematic review.
Authors: Shrestha, Rajeev (AUTHOR), Shaw, Emily (AUTHOR), Mullen, Liam (AUTHOR), Sinclair, David (AUTHOR), Dewhurst, Felicity (AUTHOR), Todd, Adam (AUTHOR)
Source: Palliative Medicine. Apr2026, Vol. 40 Issue 4, p490-513. 24p.
Subjects: Hemorrhage risk factors, Medical information storage & retrieval systems, Inappropriate prescribing (Medicine), Medical care use, Mortality, Research funding, Neurologic manifestations of general diseases, CINAHL database, Treatment effectiveness, Deprescribing, Medication error prevention, Patient care, Chronic diseases, Systematic reviews, MEDLINE, Experimental design, Health facilities, Drugs, Psychology information storage & retrieval systems, Algorithms, Drug utilization, Medical care costs, Accidental falls, Disease risk factors
Abstract: Background: Polypharmacy and inappropriate medication are common amongst people with life-limiting conditions. Whilst deprescribing may help reduce these medication-related issues, supporting evidence in this population group is limited. Aim: To synthesise evidence on the outcomes of deprescribing in people with life-limiting conditions. Design: Systematic review. Data source: MEDLINE, Embase, Scopus, PsycINFO and CINAHL were searched. Original studies published between Jan 2000 and Dec 2024 in English were included. Result: A total of 17,457 hits were screened, of which 46 original studies met the inclusion criteria. Most eligible studies were pre-post interventional (n = 14) or cohort studies (n = 14), conducted primarily in nursing homes or long-term care facilities (n = 20) and hospitals (n = 16). The majority originated from North America (n = 20) and Australia (n = 7). A wide range of outcome variables were examined, with a primary focus on clinical outcomes. All studies assessing the impact on the number of medications used reported either a reduction in overall medication burden or inappropriate medications (n = 15), or no significant change (n = 3). Regarding mortality, most studies (10 studies) reported no impact, while 3 studies each reported increased and decreased mortality. For other outcomes, the majority of studies reported that deprescribing had no effect. Conclusion: This systematic review suggests that deprescribing offers some benefits, including reduced medication burden and costs in people with life-limiting conditions. While there is no strong evidence for harm, a small proportion of patients reported increased risks, so careful monitoring is essential. Further research should explore how deprescribing outcomes vary by disease condition and medication type. [ABSTRACT FROM AUTHOR]
Copyright of Palliative Medicine is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Outcomes of deprescribing for people with life-limiting conditions: A systematic review.
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  Data: <searchLink fieldCode="AR" term="%22Shrestha%2C+Rajeev%22">Shrestha, Rajeev</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shaw%2C+Emily%22">Shaw, Emily</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mullen%2C+Liam%22">Mullen, Liam</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sinclair%2C+David%22">Sinclair, David</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dewhurst%2C+Felicity%22">Dewhurst, Felicity</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Todd%2C+Adam%22">Todd, Adam</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Palliative+Medicine%22">Palliative Medicine</searchLink>. Apr2026, Vol. 40 Issue 4, p490-513. 24p.
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  Data: <searchLink fieldCode="DE" term="%22Hemorrhage+risk+factors%22">Hemorrhage risk factors</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+information+storage+%26+retrieval+systems%22">Medical information storage & retrieval systems</searchLink><br /><searchLink fieldCode="DE" term="%22Inappropriate+prescribing+%28Medicine%29%22">Inappropriate prescribing (Medicine)</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+care+use%22">Medical care use</searchLink><br /><searchLink fieldCode="DE" term="%22Mortality%22">Mortality</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Neurologic+manifestations+of+general+diseases%22">Neurologic manifestations of general diseases</searchLink><br /><searchLink fieldCode="DE" term="%22CINAHL+database%22">CINAHL database</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Deprescribing%22">Deprescribing</searchLink><br /><searchLink fieldCode="DE" term="%22Medication+error+prevention%22">Medication error prevention</searchLink><br /><searchLink fieldCode="DE" term="%22Patient+care%22">Patient care</searchLink><br /><searchLink fieldCode="DE" term="%22Chronic+diseases%22">Chronic diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Systematic+reviews%22">Systematic reviews</searchLink><br /><searchLink fieldCode="DE" term="%22MEDLINE%22">MEDLINE</searchLink><br /><searchLink fieldCode="DE" term="%22Experimental+design%22">Experimental design</searchLink><br /><searchLink fieldCode="DE" term="%22Health+facilities%22">Health facilities</searchLink><br /><searchLink fieldCode="DE" term="%22Drugs%22">Drugs</searchLink><br /><searchLink fieldCode="DE" term="%22Psychology+information+storage+%26+retrieval+systems%22">Psychology information storage & retrieval systems</searchLink><br /><searchLink fieldCode="DE" term="%22Algorithms%22">Algorithms</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+utilization%22">Drug utilization</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+care+costs%22">Medical care costs</searchLink><br /><searchLink fieldCode="DE" term="%22Accidental+falls%22">Accidental falls</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+risk+factors%22">Disease risk factors</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Polypharmacy and inappropriate medication are common amongst people with life-limiting conditions. Whilst deprescribing may help reduce these medication-related issues, supporting evidence in this population group is limited. Aim: To synthesise evidence on the outcomes of deprescribing in people with life-limiting conditions. Design: Systematic review. Data source: MEDLINE, Embase, Scopus, PsycINFO and CINAHL were searched. Original studies published between Jan 2000 and Dec 2024 in English were included. Result: A total of 17,457 hits were screened, of which 46 original studies met the inclusion criteria. Most eligible studies were pre-post interventional (n = 14) or cohort studies (n = 14), conducted primarily in nursing homes or long-term care facilities (n = 20) and hospitals (n = 16). The majority originated from North America (n = 20) and Australia (n = 7). A wide range of outcome variables were examined, with a primary focus on clinical outcomes. All studies assessing the impact on the number of medications used reported either a reduction in overall medication burden or inappropriate medications (n = 15), or no significant change (n = 3). Regarding mortality, most studies (10 studies) reported no impact, while 3 studies each reported increased and decreased mortality. For other outcomes, the majority of studies reported that deprescribing had no effect. Conclusion: This systematic review suggests that deprescribing offers some benefits, including reduced medication burden and costs in people with life-limiting conditions. While there is no strong evidence for harm, a small proportion of patients reported increased risks, so careful monitoring is essential. Further research should explore how deprescribing outcomes vary by disease condition and medication type. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Palliative Medicine is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1177/02692163261416281
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 24
        StartPage: 490
    Subjects:
      – SubjectFull: Hemorrhage risk factors
        Type: general
      – SubjectFull: Medical information storage & retrieval systems
        Type: general
      – SubjectFull: Inappropriate prescribing (Medicine)
        Type: general
      – SubjectFull: Medical care use
        Type: general
      – SubjectFull: Mortality
        Type: general
      – SubjectFull: Research funding
        Type: general
      – SubjectFull: Neurologic manifestations of general diseases
        Type: general
      – SubjectFull: CINAHL database
        Type: general
      – SubjectFull: Treatment effectiveness
        Type: general
      – SubjectFull: Deprescribing
        Type: general
      – SubjectFull: Medication error prevention
        Type: general
      – SubjectFull: Patient care
        Type: general
      – SubjectFull: Chronic diseases
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      – SubjectFull: Systematic reviews
        Type: general
      – SubjectFull: MEDLINE
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      – SubjectFull: Experimental design
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      – SubjectFull: Health facilities
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      – SubjectFull: Drugs
        Type: general
      – SubjectFull: Psychology information storage & retrieval systems
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      – SubjectFull: Algorithms
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      – SubjectFull: Drug utilization
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      – SubjectFull: Medical care costs
        Type: general
      – SubjectFull: Accidental falls
        Type: general
      – SubjectFull: Disease risk factors
        Type: general
    Titles:
      – TitleFull: Outcomes of deprescribing for people with life-limiting conditions: A systematic review.
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              Text: Apr2026
              Type: published
              Y: 2026
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