Donanemab in Alzheimer's disease: Promise, limitations, and implementation challenges in Australia.
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| Title: | Donanemab in Alzheimer's disease: Promise, limitations, and implementation challenges in Australia. |
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| Authors: | Dawood, Muhammad (AUTHOR), Saqib, Hasnain Wajeeh (AUTHOR) |
| Source: | Australasian Psychiatry. Apr2026, Vol. 34 Issue 2, p199-199. 1p. |
| Subjects: | Alzheimer's disease, Therapeutic use of monoclonal antibodies, Infusion therapy, Clinical trials, Biomarkers, Magnetic resonance imaging, Health equity, Amyloid plaque |
| Geographic Terms: | Australia |
| Abstract: | The article focuses on the recent approval of donanemab, a monoclonal antibody targeting insoluble amyloid-β plaques, for early Alzheimer's disease (AD) treatment in Australia. While the TRAILBLAZER-ALZ 2 trial demonstrated donanemab's ability to slow cognitive and functional decline, its use involves challenges such as amyloid-related imaging abnormalities requiring intensive MRI monitoring and limited applicability to diverse populations. Practical barriers include the need for specialized infusion facilities, biomarker testing, and high costs without subsidy, raising equity concerns, especially in rural areas. The article emphasizes that donanemab is not curative and highlights the importance of preventive care, symptomatic management, and culturally sensitive, coordinated strategies to ensure equitable access and effective dementia care. [Extracted from the article] |
| Copyright of Australasian Psychiatry is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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