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Impacts of Distress Intolerance and Anxiety Sensitivity on the Maintenance and Treatment of Youth Misophonia.

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Title: Impacts of Distress Intolerance and Anxiety Sensitivity on the Maintenance and Treatment of Youth Misophonia.
Authors: Cepeda, Sandra L. (AUTHOR), Milgram, Lauren (AUTHOR), Bigler, Madison E. (AUTHOR), Tonarely‐Busto, Niza A. (AUTHOR), Lewin, Adam B. (AUTHOR), Ehrenreich‐May, Jill (AUTHOR)
Source: Journal of Clinical Psychology. May2026, Vol. 82 Issue 5, p676-689. 14p.
Subjects: Misophonia, Anxiety sensitivity, Affective disorders, Cognitive therapy, Teenagers, Emotion regulation, Psychotherapy
Abstract: Objective: Misophonia often co‐occurs with emotional disorders in youth, indicating that these conditions may share underlying risk factors, such as distress intolerance and anxiety sensitivity. However, the specific relationships between misophonia severity, distress intolerance, and anxiety sensitivity have not been formally explored. Understanding how these transdiagnostic risk factors impact misophonia severity and related impairment could offer valuable insights into misophonia phenomenology and identify key therapeutic targets for affected youth. Methods: This study examined the impacts of distress intolerance and anxiety sensitivity on misophonia severity during treatment in youth (N = 43) randomized to either a 10‐week course of the Unified Protocols for Transdiagnostic Treatment of Emotional Disorders in Children and Adolescents (UP‐C/A; N = 29) or psychoeducation/relaxation training (PRT; N = 14). Youth completed self‐report measures at 0‐, 5‐, and 10‐weeks post‐enrollment. Results: Greater distress intolerance and anxiety sensitivity were both associated with greater misophonia symptom severity at pre‐treatment. Distress intolerance, but not anxiety sensitivity, improved significantly across treatment course. Compared to youth receiving PRT, youth receiving UP‐C/A exhibited greater improvements in distress intolerance across treatment, and indirect effect estimates indicated that improvement in distress intolerance was a mechanism through which the UP‐C/A elicited change in misophonia symptom severity. Conclusion: Preliminary findings support distress intolerance as a mechanism of symptom change in transdiagnostic cognitive‐behavioral treatment for youth misophonia. Future large‐scale trials are warranted to further investigate distress intolerance and other transdiagnostic factors as treatment targets for misophonia. Clinical Trial Registration: This study was registered on ClinicalTrials. gov (NCT04365543). [ABSTRACT FROM AUTHOR]
Copyright of Journal of Clinical Psychology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Impacts of Distress Intolerance and Anxiety Sensitivity on the Maintenance and Treatment of Youth Misophonia.
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  Data: <searchLink fieldCode="AR" term="%22Cepeda%2C+Sandra+L%2E%22">Cepeda, Sandra L.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Milgram%2C+Lauren%22">Milgram, Lauren</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bigler%2C+Madison+E%2E%22">Bigler, Madison E.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tonarely‐Busto%2C+Niza+A%2E%22">Tonarely‐Busto, Niza A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lewin%2C+Adam+B%2E%22">Lewin, Adam B.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ehrenreich‐May%2C+Jill%22">Ehrenreich‐May, Jill</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Clinical+Psychology%22">Journal of Clinical Psychology</searchLink>. May2026, Vol. 82 Issue 5, p676-689. 14p.
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  Data: <searchLink fieldCode="DE" term="%22Misophonia%22">Misophonia</searchLink><br /><searchLink fieldCode="DE" term="%22Anxiety+sensitivity%22">Anxiety sensitivity</searchLink><br /><searchLink fieldCode="DE" term="%22Affective+disorders%22">Affective disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Cognitive+therapy%22">Cognitive therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Teenagers%22">Teenagers</searchLink><br /><searchLink fieldCode="DE" term="%22Emotion+regulation%22">Emotion regulation</searchLink><br /><searchLink fieldCode="DE" term="%22Psychotherapy%22">Psychotherapy</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective: Misophonia often co‐occurs with emotional disorders in youth, indicating that these conditions may share underlying risk factors, such as distress intolerance and anxiety sensitivity. However, the specific relationships between misophonia severity, distress intolerance, and anxiety sensitivity have not been formally explored. Understanding how these transdiagnostic risk factors impact misophonia severity and related impairment could offer valuable insights into misophonia phenomenology and identify key therapeutic targets for affected youth. Methods: This study examined the impacts of distress intolerance and anxiety sensitivity on misophonia severity during treatment in youth (N = 43) randomized to either a 10‐week course of the Unified Protocols for Transdiagnostic Treatment of Emotional Disorders in Children and Adolescents (UP‐C/A; N = 29) or psychoeducation/relaxation training (PRT; N = 14). Youth completed self‐report measures at 0‐, 5‐, and 10‐weeks post‐enrollment. Results: Greater distress intolerance and anxiety sensitivity were both associated with greater misophonia symptom severity at pre‐treatment. Distress intolerance, but not anxiety sensitivity, improved significantly across treatment course. Compared to youth receiving PRT, youth receiving UP‐C/A exhibited greater improvements in distress intolerance across treatment, and indirect effect estimates indicated that improvement in distress intolerance was a mechanism through which the UP‐C/A elicited change in misophonia symptom severity. Conclusion: Preliminary findings support distress intolerance as a mechanism of symptom change in transdiagnostic cognitive‐behavioral treatment for youth misophonia. Future large‐scale trials are warranted to further investigate distress intolerance and other transdiagnostic factors as treatment targets for misophonia. Clinical Trial Registration: This study was registered on ClinicalTrials. gov (NCT04365543). [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Clinical Psychology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1002/jclp.70095
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        Text: English
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      – SubjectFull: Misophonia
        Type: general
      – SubjectFull: Anxiety sensitivity
        Type: general
      – SubjectFull: Affective disorders
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      – TitleFull: Impacts of Distress Intolerance and Anxiety Sensitivity on the Maintenance and Treatment of Youth Misophonia.
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              Text: May2026
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              Y: 2026
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