Correlations between antiseizure medications and interictal epileptiform discharges in the idiopathic generalized epilepsies: A retrospective exploratory analysis of home video‐electroencephalographic studies.
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| Title: | Correlations between antiseizure medications and interictal epileptiform discharges in the idiopathic generalized epilepsies: A retrospective exploratory analysis of home video‐electroencephalographic studies. |
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| Authors: | Arnaout, Basheer (AUTHOR), Xu, Andrew (AUTHOR), Shadid, Omar (AUTHOR), Karoly, Philippa J. (AUTHOR), Cook, Mark J. (AUTHOR), Nurse, Ewan S. (AUTHOR) |
| Source: | Epilepsia (Series 4). Apr2026, Vol. 67 Issue 4, p1654-1664. 11p. |
| Subjects: | Epileptiform discharges, Anticonvulsants, Lamotrigine, Carbamazepine, Valproic acid, Epilepsy, Levetiracetam |
| Abstract: | Objective: This study was undertaken to investigate the efficacy of antiseizure medications in reducing interictal epileptic discharges (IEDs) in patients with idiopathic generalized epilepsies (IGEs) and to explore the relationship between IED measures and clinical events. We hypothesize that valproate and ethosuximide are superior to levetiracetam, which in turn is superior to lamotrigine in reducing IED activity. Methods: We performed a retrospective analysis of 577 video‐electroencephalographic studies in individuals with IGEs over a median recording duration of 5 days. Clinical variables analyzed for each study included the following: antiseizure medication regimen, seizure occurrence, mean, median, and maximum IED durations, IED rate (events per hour), and IED burden (percentage of the recording containing IEDs). All IED outcomes were measured twice: for all detected IEDs and for IEDs ≥3 s. Results: Linear regression analysis of the monotherapy regimens found that carbamazepine was associated with greater IED rates (all: β = 20.0 events/h, p <.001; ≥3 s: β = 2.4 events/h, p <.001). Similarly, regression analysis of the dual therapy regimens revealed that valproate and lamotrigine were associated with reduced IED rates and burdens in the overall cohort (rate: β = −18.0 events/h, p =.028; burden: β = −.62%, p =.031). Additionally, participants with detected seizures exhibited higher IED durations, rates, and burdens than those without seizures, in both the overall and ≥3‐s cohorts (all p <.001). These findings do not conclusively support or reject the hypothesis. Significance: Carbamazepine is associated with increased interictal event rate, whereas the valproate and lamotrigine combination is associated with reduced interictal event rate and burden. Our findings also demonstrate that increased IED outcomes are associated with seizure occurrence. [ABSTRACT FROM AUTHOR] |
| Copyright of Epilepsia (Series 4) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 192955186 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Correlations between antiseizure medications and interictal epileptiform discharges in the idiopathic generalized epilepsies: A retrospective exploratory analysis of home video‐electroencephalographic studies. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Arnaout%2C+Basheer%22">Arnaout, Basheer</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xu%2C+Andrew%22">Xu, Andrew</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shadid%2C+Omar%22">Shadid, Omar</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Karoly%2C+Philippa+J%2E%22">Karoly, Philippa J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cook%2C+Mark+J%2E%22">Cook, Mark J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nurse%2C+Ewan+S%2E%22">Nurse, Ewan S.</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Epilepsia+%28Series+4%29%22">Epilepsia (Series 4)</searchLink>. Apr2026, Vol. 67 Issue 4, p1654-1664. 11p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Epileptiform+discharges%22">Epileptiform discharges</searchLink><br /><searchLink fieldCode="DE" term="%22Anticonvulsants%22">Anticonvulsants</searchLink><br /><searchLink fieldCode="DE" term="%22Lamotrigine%22">Lamotrigine</searchLink><br /><searchLink fieldCode="DE" term="%22Carbamazepine%22">Carbamazepine</searchLink><br /><searchLink fieldCode="DE" term="%22Valproic+acid%22">Valproic acid</searchLink><br /><searchLink fieldCode="DE" term="%22Epilepsy%22">Epilepsy</searchLink><br /><searchLink fieldCode="DE" term="%22Levetiracetam%22">Levetiracetam</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Objective: This study was undertaken to investigate the efficacy of antiseizure medications in reducing interictal epileptic discharges (IEDs) in patients with idiopathic generalized epilepsies (IGEs) and to explore the relationship between IED measures and clinical events. We hypothesize that valproate and ethosuximide are superior to levetiracetam, which in turn is superior to lamotrigine in reducing IED activity. Methods: We performed a retrospective analysis of 577 video‐electroencephalographic studies in individuals with IGEs over a median recording duration of 5 days. Clinical variables analyzed for each study included the following: antiseizure medication regimen, seizure occurrence, mean, median, and maximum IED durations, IED rate (events per hour), and IED burden (percentage of the recording containing IEDs). All IED outcomes were measured twice: for all detected IEDs and for IEDs ≥3 s. Results: Linear regression analysis of the monotherapy regimens found that carbamazepine was associated with greater IED rates (all: β = 20.0 events/h, p <.001; ≥3 s: β = 2.4 events/h, p <.001). Similarly, regression analysis of the dual therapy regimens revealed that valproate and lamotrigine were associated with reduced IED rates and burdens in the overall cohort (rate: β = −18.0 events/h, p =.028; burden: β = −.62%, p =.031). Additionally, participants with detected seizures exhibited higher IED durations, rates, and burdens than those without seizures, in both the overall and ≥3‐s cohorts (all p <.001). These findings do not conclusively support or reject the hypothesis. Significance: Carbamazepine is associated with increased interictal event rate, whereas the valproate and lamotrigine combination is associated with reduced interictal event rate and burden. Our findings also demonstrate that increased IED outcomes are associated with seizure occurrence. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Epilepsia (Series 4) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/epi.70072 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 1654 Subjects: – SubjectFull: Epileptiform discharges Type: general – SubjectFull: Anticonvulsants Type: general – SubjectFull: Lamotrigine Type: general – SubjectFull: Carbamazepine Type: general – SubjectFull: Valproic acid Type: general – SubjectFull: Epilepsy Type: general – SubjectFull: Levetiracetam Type: general Titles: – TitleFull: Correlations between antiseizure medications and interictal epileptiform discharges in the idiopathic generalized epilepsies: A retrospective exploratory analysis of home video‐electroencephalographic studies. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Arnaout, Basheer – PersonEntity: Name: NameFull: Xu, Andrew – PersonEntity: Name: NameFull: Shadid, Omar – PersonEntity: Name: NameFull: Karoly, Philippa J. – PersonEntity: Name: NameFull: Cook, Mark J. – PersonEntity: Name: NameFull: Nurse, Ewan S. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 04 Text: Apr2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 00139580 Numbering: – Type: volume Value: 67 – Type: issue Value: 4 Titles: – TitleFull: Epilepsia (Series 4) Type: main |
| ResultId | 1 |
