View in EDS

Electroconvulsive Shock Induces Greater Plasticity of Dentate Gyrus Neurons Born in Adulthood Than Those Born in Development.

Saved in:
Bibliographic Details
Title: Electroconvulsive Shock Induces Greater Plasticity of Dentate Gyrus Neurons Born in Adulthood Than Those Born in Development.
Authors: Zhang, T. R. (AUTHOR), Askari, B. (AUTHOR), Smith, Rachel (AUTHOR), Mallela, Likitha (AUTHOR), Vila‐Rodriguez, F. (AUTHOR), Snyder, J. S. (AUTHOR)
Source: European Journal of Neuroscience. Apr2026, Vol. 63 Issue 7, p1-14. 14p.
Subjects: Dentate gyrus, Neuroplasticity, Neuron development, Mental depression, Electroconvulsive therapy, Neurogenesis
Abstract: Electroconvulsive therapy (ECT) is the most effective treatment for severe depression but uptake is hindered due to effects on memory and a poor understanding of its mechanisms of action. Hippocampal plasticity is one consequence of ECT that may be related to both the therapeutic and amnestic effects. In animals, electroconvulsive shock (ECS) dramatically increases adult neurogenesis in the dentate gyrus (DG). However, little is known about how ECS impacts the morphology of adult‐born neurons. Moreover, it is unknown whether ECS differentially impacts DG neurons that are born in development versus adulthood. To address these questions, here, we subjected male and female mice to a clinically relevant schedule of chronic ECS and examined effects on DG neuron populations. As predicted, ECS dramatically increased the survival of adult‐born DG neurons generated shortly before treatment and the number of immature neurons present after treatment. Adult‐born neurons from ECS‐treated mice also had longer dendrites and larger presynaptic terminals, suggesting enhanced circuit integration. In contrast, ECS did not affect the survival of neurons born in early postnatal development and it did not alter the structure of their dendrites or presynaptic terminals. Instead, ECS reduced spine density on developmentally born neurons in the dorsal DG and, in the ventral DG, it increased mushroom spine density. Thus, adult‐born neurons generally display greater ECS‐induced plasticity than developmentally born neurons, which may be relevant for the effects of ECS/ECT on cognition and mood. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 192955360
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Electroconvulsive Shock Induces Greater Plasticity of Dentate Gyrus Neurons Born in Adulthood Than Those Born in Development.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Zhang%2C+T%2E R%2E%22">Zhang, T. R.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Askari%2C+B%2E%22">Askari, B.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Smith%2C+Rachel%22">Smith, Rachel</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mallela%2C+Likitha%22">Mallela, Likitha</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vila‐Rodriguez%2C+F%2E%22">Vila‐Rodriguez, F.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Snyder%2C+J%2E S%2E%22">Snyder, J. S.</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Apr2026, Vol. 63 Issue 7, p1-14. 14p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Dentate+gyrus%22">Dentate gyrus</searchLink><br /><searchLink fieldCode="DE" term="%22Neuroplasticity%22">Neuroplasticity</searchLink><br /><searchLink fieldCode="DE" term="%22Neuron+development%22">Neuron development</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Electroconvulsive+therapy%22">Electroconvulsive therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Neurogenesis%22">Neurogenesis</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Electroconvulsive therapy (ECT) is the most effective treatment for severe depression but uptake is hindered due to effects on memory and a poor understanding of its mechanisms of action. Hippocampal plasticity is one consequence of ECT that may be related to both the therapeutic and amnestic effects. In animals, electroconvulsive shock (ECS) dramatically increases adult neurogenesis in the dentate gyrus (DG). However, little is known about how ECS impacts the morphology of adult‐born neurons. Moreover, it is unknown whether ECS differentially impacts DG neurons that are born in development versus adulthood. To address these questions, here, we subjected male and female mice to a clinically relevant schedule of chronic ECS and examined effects on DG neuron populations. As predicted, ECS dramatically increased the survival of adult‐born DG neurons generated shortly before treatment and the number of immature neurons present after treatment. Adult‐born neurons from ECS‐treated mice also had longer dendrites and larger presynaptic terminals, suggesting enhanced circuit integration. In contrast, ECS did not affect the survival of neurons born in early postnatal development and it did not alter the structure of their dendrites or presynaptic terminals. Instead, ECS reduced spine density on developmentally born neurons in the dorsal DG and, in the ventral DG, it increased mushroom spine density. Thus, adult‐born neurons generally display greater ECS‐induced plasticity than developmentally born neurons, which may be relevant for the effects of ECS/ECT on cognition and mood. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=192955360
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/ejn.70492
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 14
        StartPage: 1
    Subjects:
      – SubjectFull: Dentate gyrus
        Type: general
      – SubjectFull: Neuroplasticity
        Type: general
      – SubjectFull: Neuron development
        Type: general
      – SubjectFull: Mental depression
        Type: general
      – SubjectFull: Electroconvulsive therapy
        Type: general
      – SubjectFull: Neurogenesis
        Type: general
    Titles:
      – TitleFull: Electroconvulsive Shock Induces Greater Plasticity of Dentate Gyrus Neurons Born in Adulthood Than Those Born in Development.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Zhang, T. R.
      – PersonEntity:
          Name:
            NameFull: Askari, B.
      – PersonEntity:
          Name:
            NameFull: Smith, Rachel
      – PersonEntity:
          Name:
            NameFull: Mallela, Likitha
      – PersonEntity:
          Name:
            NameFull: Vila‐Rodriguez, F.
      – PersonEntity:
          Name:
            NameFull: Snyder, J. S.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 04
              Text: Apr2026
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-print
              Value: 0953816X
          Numbering:
            – Type: volume
              Value: 63
            – Type: issue
              Value: 7
          Titles:
            – TitleFull: European Journal of Neuroscience
              Type: main
ResultId 1