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Transdermal oestradiol and testosterone therapy for menopausal depression and mood symptoms: retrospective cohort study.

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Title: Transdermal oestradiol and testosterone therapy for menopausal depression and mood symptoms: retrospective cohort study.
Authors: Glynne, Sarah (AUTHOR), Kamal, Aini (AUTHOR), McColl, Lynsey (AUTHOR), Newson, Louise (AUTHOR), Reisel, Daniel (AUTHOR), Mu, Eveline (AUTHOR), Hendriks, Olivia (AUTHOR), Saini, Pooja (AUTHOR), Gurvich, Caroline (AUTHOR), Kulkarni, Jayashri (AUTHOR)
Source: British Journal of Psychiatry. May2026, Vol. 228 Issue 5, p409-418. 10p.
Subjects: Hormone therapy for menopause, Mental depression, Cohort analysis, Hormone therapy, Perimenopause, Postmenopause, Estradiol
Abstract: Background: Psychological symptoms in perimenopause and early menopause are common. The impact of menopausal hormone therapy (MHT) on menopausal mood symptoms is unclear. Aims: To assess the impact of 17β-oestradiol ± micronised progesterone or the levonorgestrel-releasing intrauterine device, and/or transdermal testosterone, on depressive and anxiety symptoms in peri- and postmenopausal women. Method: A real-world retrospective cohort study set in the largest specialist menopause clinic in the UK. The Meno-D questionnaire measured mood-related symptoms. Results: The study included 920 women: 448 (48.7%) perimenopausal, and 435 (47.3%) postmenopausal. Following initiation/optimisation of MHT, mean Meno-D scores decreased by 44.59% (95% CI −46.83% to −42.34%, P < 0.001) after average 107 days follow-up. Mood symptoms significantly improved (P < 0.01 per symptom). Improvement occurred in peri- and postmenopausal women. All MHT regimens improved mental health including both progestogen types (body-identical progesterone and levonorgestrel-releasing intrauterine device), MHT initiation strategy (oestradiol ± a progestogen versus oestradiol ± a progestogen and testosterone, 45.38 v. 48.53%, respectively, P = 0.47) and MHT optimisation strategy (MHT users treated with a higher oestradiol dose versus testosterone added versus both a higher oestradiol dose and testosterone, 34.70, 43.93 and 43.25%, respectively, P = 0.38). Conclusions: Use of menopausal hormone therapy was associated with significant improvement in mood in peri- and postmenopausal women. Prospective studies and randomised clinical trials are needed to assess the effects of different regimens in different patient populations over longer time periods. [ABSTRACT FROM AUTHOR]
Copyright of British Journal of Psychiatry is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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DbLabel: Psychology and Behavioral Sciences Collection
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PubTypeId: academicJournal
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  Label: Title
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  Data: Transdermal oestradiol and testosterone therapy for menopausal depression and mood symptoms: retrospective cohort study.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Glynne%2C+Sarah%22&quot;&gt;Glynne, Sarah&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Kamal%2C+Aini%22&quot;&gt;Kamal, Aini&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22McColl%2C+Lynsey%22&quot;&gt;McColl, Lynsey&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Newson%2C+Louise%22&quot;&gt;Newson, Louise&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Reisel%2C+Daniel%22&quot;&gt;Reisel, Daniel&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Mu%2C+Eveline%22&quot;&gt;Mu, Eveline&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Hendriks%2C+Olivia%22&quot;&gt;Hendriks, Olivia&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Saini%2C+Pooja%22&quot;&gt;Saini, Pooja&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Gurvich%2C+Caroline%22&quot;&gt;Gurvich, Caroline&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Kulkarni%2C+Jayashri%22&quot;&gt;Kulkarni, Jayashri&lt;/searchLink&gt; (AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22British+Journal+of+Psychiatry%22&quot;&gt;British Journal of Psychiatry&lt;/searchLink&gt;. May2026, Vol. 228 Issue 5, p409-418. 10p.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Hormone+therapy+for+menopause%22&quot;&gt;Hormone therapy for menopause&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Mental+depression%22&quot;&gt;Mental depression&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Cohort+analysis%22&quot;&gt;Cohort analysis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Hormone+therapy%22&quot;&gt;Hormone therapy&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Perimenopause%22&quot;&gt;Perimenopause&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Postmenopause%22&quot;&gt;Postmenopause&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Estradiol%22&quot;&gt;Estradiol&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Psychological symptoms in perimenopause and early menopause are common. The impact of menopausal hormone therapy (MHT) on menopausal mood symptoms is unclear. Aims: To assess the impact of 17β-oestradiol &#177; micronised progesterone or the levonorgestrel-releasing intrauterine device, and/or transdermal testosterone, on depressive and anxiety symptoms in peri- and postmenopausal women. Method: A real-world retrospective cohort study set in the largest specialist menopause clinic in the UK. The Meno-D questionnaire measured mood-related symptoms. Results: The study included 920 women: 448 (48.7%) perimenopausal, and 435 (47.3%) postmenopausal. Following initiation/optimisation of MHT, mean Meno-D scores decreased by 44.59% (95% CI −46.83% to −42.34%, P &lt; 0.001) after average 107 days follow-up. Mood symptoms significantly improved (P &lt; 0.01 per symptom). Improvement occurred in peri- and postmenopausal women. All MHT regimens improved mental health including both progestogen types (body-identical progesterone and levonorgestrel-releasing intrauterine device), MHT initiation strategy (oestradiol &#177; a progestogen versus oestradiol &#177; a progestogen and testosterone, 45.38 v. 48.53%, respectively, P = 0.47) and MHT optimisation strategy (MHT users treated with a higher oestradiol dose versus testosterone added versus both a higher oestradiol dose and testosterone, 34.70, 43.93 and 43.25%, respectively, P = 0.38). Conclusions: Use of menopausal hormone therapy was associated with significant improvement in mood in peri- and postmenopausal women. Prospective studies and randomised clinical trials are needed to assess the effects of different regimens in different patient populations over longer time periods. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: &lt;i&gt;Copyright of British Journal of Psychiatry is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1192/bjp.2025.101
    Languages:
      – Code: eng
        Text: English
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      Pagination:
        PageCount: 10
        StartPage: 409
    Subjects:
      – SubjectFull: Hormone therapy for menopause
        Type: general
      – SubjectFull: Mental depression
        Type: general
      – SubjectFull: Cohort analysis
        Type: general
      – SubjectFull: Hormone therapy
        Type: general
      – SubjectFull: Perimenopause
        Type: general
      – SubjectFull: Postmenopause
        Type: general
      – SubjectFull: Estradiol
        Type: general
    Titles:
      – TitleFull: Transdermal oestradiol and testosterone therapy for menopausal depression and mood symptoms: retrospective cohort study.
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            – D: 01
              M: 05
              Text: May2026
              Type: published
              Y: 2026
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