Transdermal oestradiol and testosterone therapy for menopausal depression and mood symptoms: retrospective cohort study.
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| Title: | Transdermal oestradiol and testosterone therapy for menopausal depression and mood symptoms: retrospective cohort study. |
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| Authors: | Glynne, Sarah (AUTHOR), Kamal, Aini (AUTHOR), McColl, Lynsey (AUTHOR), Newson, Louise (AUTHOR), Reisel, Daniel (AUTHOR), Mu, Eveline (AUTHOR), Hendriks, Olivia (AUTHOR), Saini, Pooja (AUTHOR), Gurvich, Caroline (AUTHOR), Kulkarni, Jayashri (AUTHOR) |
| Source: | British Journal of Psychiatry. May2026, Vol. 228 Issue 5, p409-418. 10p. |
| Subjects: | Hormone therapy for menopause, Mental depression, Cohort analysis, Hormone therapy, Perimenopause, Postmenopause, Estradiol |
| Abstract: | Background: Psychological symptoms in perimenopause and early menopause are common. The impact of menopausal hormone therapy (MHT) on menopausal mood symptoms is unclear. Aims: To assess the impact of 17β-oestradiol ± micronised progesterone or the levonorgestrel-releasing intrauterine device, and/or transdermal testosterone, on depressive and anxiety symptoms in peri- and postmenopausal women. Method: A real-world retrospective cohort study set in the largest specialist menopause clinic in the UK. The Meno-D questionnaire measured mood-related symptoms. Results: The study included 920 women: 448 (48.7%) perimenopausal, and 435 (47.3%) postmenopausal. Following initiation/optimisation of MHT, mean Meno-D scores decreased by 44.59% (95% CI −46.83% to −42.34%, P < 0.001) after average 107 days follow-up. Mood symptoms significantly improved (P < 0.01 per symptom). Improvement occurred in peri- and postmenopausal women. All MHT regimens improved mental health including both progestogen types (body-identical progesterone and levonorgestrel-releasing intrauterine device), MHT initiation strategy (oestradiol ± a progestogen versus oestradiol ± a progestogen and testosterone, 45.38 v. 48.53%, respectively, P = 0.47) and MHT optimisation strategy (MHT users treated with a higher oestradiol dose versus testosterone added versus both a higher oestradiol dose and testosterone, 34.70, 43.93 and 43.25%, respectively, P = 0.38). Conclusions: Use of menopausal hormone therapy was associated with significant improvement in mood in peri- and postmenopausal women. Prospective studies and randomised clinical trials are needed to assess the effects of different regimens in different patient populations over longer time periods. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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