Joint Association of Household Pesticide Exposure With Depression in Adults: A Cross‐Sectional Analysis From National Health and Nutrition Examination Survey 2007–2014.
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| Title: | Joint Association of Household Pesticide Exposure With Depression in Adults: A Cross‐Sectional Analysis From National Health and Nutrition Examination Survey 2007–2014. |
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| Authors: | Chen, Mingjun (AUTHOR), Dai, Hengheng (AUTHOR), Tong, ZhanQi (AUTHOR), Lin, Mingxiong (AUTHOR), Bosurgi, Raffaella (AUTHOR) |
| Source: | Depression & Anxiety (1091-4269). 4/16/2026, Vol. 2026, p1-15. 15p. |
| Subjects: | Mental depression, Environmental exposure, Sex factors in disease, Statistical models, Pyrethroids, Biomarkers, Adults, Psychological vulnerability |
| Abstract: | Objectives: This study aimed to investigate the association between household pesticide exposure and depression risk in adults, with a particular focus on sex‐ and age‐specific vulnerabilities. The analysis utilized integrated biomarker assessment and advanced mixture modeling techniques. Methods: Cross‐sectional data from 6502 adults (National Health and Nutrition Examination Survey [NHANES] 2007–2014) were analyzed. Household pesticide exposure was evaluated through self‐reports as well as urinary metabolites (DEET, DCBA, DHMB, 3‐phenoxybenzoic acid [3‐PBA], 4F‐3‐PBA, and cis‐DCBA). To assess exposure–response relationships, nonlinear trends, and mixture effects while adjusting for sociodemographic factors, lifestyle choices, and clinical covariates, we employed survey‐weighted logistic regression models along with restricted cubic spline (RCS), Bayesian kernel machine regression (BKMR), and weighted quantile sum (WQS) analyses. Results: Self‐reported pesticide exposure demonstrated a marginal association with depression (adjusted odds ratio [OR] = 1.43; 95% confidence interval [CI]: 0.91–2.25). Urinary pyrethroid metabolite 3‐PBA exhibited dose‐dependent relationships with depression (OR = 1.02 per 1 μg/L; 95% CI: 1.00–1.04). Notable sex‐specific vulnerabilities were identified; females exhibited stronger associations with both 3‐PBA (OR = 1.04) and 4F‐3‐PBA (OR = 1.69), whereas males showed heightened sensitivity to DCBA (weight = 0.35). Mixture analyses indicated joint effects involving DHMB and 3‐PBA as notable contributors to the observed outcomes. Additionally, fatigue (OR = 1.26), self‐blame (OR = 1.30), and appetite disturbances (OR = 1.17) statistically contributed to pesticide exposure. Nonlinear dose–response patterns were particularly evident among males and younger adults. Conclusions: This cross‐sectional analysis demonstrates an association between exposure to household pesticides, particularly pyrethroids, and an increased risk of depression, with variation across demographic groups. These findings underscore the need for further longitudinal investigation to establish causality and understand the implications of pesticide usage on public health. [ABSTRACT FROM AUTHOR] |
| Copyright of Depression & Anxiety (1091-4269) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 193087627 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Joint Association of Household Pesticide Exposure With Depression in Adults: A Cross‐Sectional Analysis From National Health and Nutrition Examination Survey 2007–2014. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Chen%2C+Mingjun%22">Chen, Mingjun</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dai%2C+Hengheng%22">Dai, Hengheng</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tong%2C+ZhanQi%22">Tong, ZhanQi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lin%2C+Mingxiong%22">Lin, Mingxiong</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bosurgi%2C+Raffaella%22">Bosurgi, Raffaella</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Depression+%26+Anxiety+%281091-4269%29%22">Depression & Anxiety (1091-4269)</searchLink>. 4/16/2026, Vol. 2026, p1-15. 15p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Environmental+exposure%22">Environmental exposure</searchLink><br /><searchLink fieldCode="DE" term="%22Sex+factors+in+disease%22">Sex factors in disease</searchLink><br /><searchLink fieldCode="DE" term="%22Statistical+models%22">Statistical models</searchLink><br /><searchLink fieldCode="DE" term="%22Pyrethroids%22">Pyrethroids</searchLink><br /><searchLink fieldCode="DE" term="%22Biomarkers%22">Biomarkers</searchLink><br /><searchLink fieldCode="DE" term="%22Adults%22">Adults</searchLink><br /><searchLink fieldCode="DE" term="%22Psychological+vulnerability%22">Psychological vulnerability</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Objectives: This study aimed to investigate the association between household pesticide exposure and depression risk in adults, with a particular focus on sex‐ and age‐specific vulnerabilities. The analysis utilized integrated biomarker assessment and advanced mixture modeling techniques. Methods: Cross‐sectional data from 6502 adults (National Health and Nutrition Examination Survey [NHANES] 2007–2014) were analyzed. Household pesticide exposure was evaluated through self‐reports as well as urinary metabolites (DEET, DCBA, DHMB, 3‐phenoxybenzoic acid [3‐PBA], 4F‐3‐PBA, and cis‐DCBA). To assess exposure–response relationships, nonlinear trends, and mixture effects while adjusting for sociodemographic factors, lifestyle choices, and clinical covariates, we employed survey‐weighted logistic regression models along with restricted cubic spline (RCS), Bayesian kernel machine regression (BKMR), and weighted quantile sum (WQS) analyses. Results: Self‐reported pesticide exposure demonstrated a marginal association with depression (adjusted odds ratio [OR] = 1.43; 95% confidence interval [CI]: 0.91–2.25). Urinary pyrethroid metabolite 3‐PBA exhibited dose‐dependent relationships with depression (OR = 1.02 per 1 μg/L; 95% CI: 1.00–1.04). Notable sex‐specific vulnerabilities were identified; females exhibited stronger associations with both 3‐PBA (OR = 1.04) and 4F‐3‐PBA (OR = 1.69), whereas males showed heightened sensitivity to DCBA (weight = 0.35). Mixture analyses indicated joint effects involving DHMB and 3‐PBA as notable contributors to the observed outcomes. Additionally, fatigue (OR = 1.26), self‐blame (OR = 1.30), and appetite disturbances (OR = 1.17) statistically contributed to pesticide exposure. Nonlinear dose–response patterns were particularly evident among males and younger adults. Conclusions: This cross‐sectional analysis demonstrates an association between exposure to household pesticides, particularly pyrethroids, and an increased risk of depression, with variation across demographic groups. These findings underscore the need for further longitudinal investigation to establish causality and understand the implications of pesticide usage on public health. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Depression & Anxiety (1091-4269) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=193087627 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1155/da/4872833 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 15 StartPage: 1 Subjects: – SubjectFull: Mental depression Type: general – SubjectFull: Environmental exposure Type: general – SubjectFull: Sex factors in disease Type: general – SubjectFull: Statistical models Type: general – SubjectFull: Pyrethroids Type: general – SubjectFull: Biomarkers Type: general – SubjectFull: Adults Type: general – SubjectFull: Psychological vulnerability Type: general Titles: – TitleFull: Joint Association of Household Pesticide Exposure With Depression in Adults: A Cross‐Sectional Analysis From National Health and Nutrition Examination Survey 2007–2014. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Chen, Mingjun – PersonEntity: Name: NameFull: Dai, Hengheng – PersonEntity: Name: NameFull: Tong, ZhanQi – PersonEntity: Name: NameFull: Lin, Mingxiong – PersonEntity: Name: NameFull: Bosurgi, Raffaella IsPartOfRelationships: – BibEntity: Dates: – D: 16 M: 04 Text: 4/16/2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 10914269 Numbering: – Type: volume Value: 2026 Titles: – TitleFull: Depression & Anxiety (1091-4269) Type: main |
| ResultId | 1 |
