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Abnormal Activation and Connection in Middle Frontal Gyrus: A Potential Imaging Feature for Facial Synkinesis Comorbid Depression.

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Title: Abnormal Activation and Connection in Middle Frontal Gyrus: A Potential Imaging Feature for Facial Synkinesis Comorbid Depression.
Authors: Guan, Haonan (AUTHOR), Wang, Luyao (AUTHOR), Dong, Fan (AUTHOR), Hu, Wenjing (AUTHOR), Zhang, Zhilin (AUTHOR), Wu, Jinglong (AUTHOR), Lu, Yue (AUTHOR), Ding, Wei (AUTHOR), Jiang, Jiehui (AUTHOR), Manthey, Marie Kristin (AUTHOR)
Source: Depression & Anxiety (1091-4269). 4/25/2026, Vol. 2026, p1-11. 11p.
Subjects: Mental depression, Functional connectivity, Facial dyskinesias, Motor ability, Prefrontal cortex, Functional magnetic resonance imaging, Limbic system, Neurons
Abstract: Patients with facial synkinesis (FS) comorbid depression may experience aggravated symptoms of perceived synkinesis and poorer recovery outcomes. Exploring imaging features associated with depressive symptoms could help us better understand disease conditions and formulate appropriate rehabilitation plans. Although abnormal activation in the middle frontal gyrus (MFG) has been reported in depression patients, whether it represents an imaging correlate of depressive symptoms in patients with FS is still unknown. Therefore, a total of 52 participants (20 normal controls [NCs], 32 patients) with both task and resting‐state functional magnetic resonance imaging (rs‐fMRI) data were included in this study. Comorbid depression was assessed with the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM‐V), and depressive symptom severity was measured with the Beck Depression Inventory‐II (BDI‐II). We investigated brain activation during motor tasks (smiling, blinking, and grinning). In addition, the seed‐based functional connectivity (FC) between the MFG and other brain areas was calculated in the resting state. Additionally, we analyzed the associations between brain activity and clinical scale scores. The results revealed reduced activation in the sensorimotor and MFG during affected side movements across all tasks (voxel‐level p < 0.05, cluster‐level p < 0.05, Gaussian random field [GRF]‐corrected). Moreover, seed‐based FC between the MFG and emotion‐related areas was increased (voxel‐level p < 0.05, cluster‐level p < 0.05, GRF‐corrected), indicating impaired emotional networks in patients. Scores on the BDI‐II were negatively associated with MFG activation during tasks (R = −0.318, p = 0.027) and positively associated with the FC of the MFG (R = 0.387, p = 0.029). Thus, the MFG activation and connectivity may represent an increased risk for elevated depressive symptoms in patients with FS, warranting further validation in future studies. Trial Registration: Chinese Clinical Trial Registry: ChiCTR1800014630. [ABSTRACT FROM AUTHOR]
Copyright of Depression & Anxiety (1091-4269) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Abnormal Activation and Connection in Middle Frontal Gyrus: A Potential Imaging Feature for Facial Synkinesis Comorbid Depression.
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  Data: Patients with facial synkinesis (FS) comorbid depression may experience aggravated symptoms of perceived synkinesis and poorer recovery outcomes. Exploring imaging features associated with depressive symptoms could help us better understand disease conditions and formulate appropriate rehabilitation plans. Although abnormal activation in the middle frontal gyrus (MFG) has been reported in depression patients, whether it represents an imaging correlate of depressive symptoms in patients with FS is still unknown. Therefore, a total of 52 participants (20 normal controls [NCs], 32 patients) with both task and resting‐state functional magnetic resonance imaging (rs‐fMRI) data were included in this study. Comorbid depression was assessed with the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM‐V), and depressive symptom severity was measured with the Beck Depression Inventory‐II (BDI‐II). We investigated brain activation during motor tasks (smiling, blinking, and grinning). In addition, the seed‐based functional connectivity (FC) between the MFG and other brain areas was calculated in the resting state. Additionally, we analyzed the associations between brain activity and clinical scale scores. The results revealed reduced activation in the sensorimotor and MFG during affected side movements across all tasks (voxel‐level p &lt; 0.05, cluster‐level p &lt; 0.05, Gaussian random field [GRF]‐corrected). Moreover, seed‐based FC between the MFG and emotion‐related areas was increased (voxel‐level p &lt; 0.05, cluster‐level p &lt; 0.05, GRF‐corrected), indicating impaired emotional networks in patients. Scores on the BDI‐II were negatively associated with MFG activation during tasks (R = −0.318, p = 0.027) and positively associated with the FC of the MFG (R = 0.387, p = 0.029). Thus, the MFG activation and connectivity may represent an increased risk for elevated depressive symptoms in patients with FS, warranting further validation in future studies. Trial Registration: Chinese Clinical Trial Registry: ChiCTR1800014630. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Depression &amp; Anxiety (1091-4269) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Value: 10.1155/da/1705507
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      – Code: eng
        Text: English
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    Subjects:
      – SubjectFull: Mental depression
        Type: general
      – SubjectFull: Functional connectivity
        Type: general
      – SubjectFull: Facial dyskinesias
        Type: general
      – SubjectFull: Motor ability
        Type: general
      – SubjectFull: Prefrontal cortex
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      – SubjectFull: Functional magnetic resonance imaging
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      – SubjectFull: Limbic system
        Type: general
      – SubjectFull: Neurons
        Type: general
    Titles:
      – TitleFull: Abnormal Activation and Connection in Middle Frontal Gyrus: A Potential Imaging Feature for Facial Synkinesis Comorbid Depression.
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              Text: 4/25/2026
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              Y: 2026
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